Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study
Abstract Background Persistent organochlorine pollutants (POPs) may interfere with reproductive function but direct evidence in humans is very limited. Methods Fertility was examined in four regions with contrasting blood levels of POPs. Pregnant women and their partners in Warsaw (Poland), Kharkiv...
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Format: | Article in Journal/Newspaper |
Language: | English |
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Springer Science and Business Media LLC
2005
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Online Access: | http://dx.doi.org/10.1186/1476-069x-4-26 http://link.springer.com/content/pdf/10.1186/1476-069X-4-26.pdf http://link.springer.com/article/10.1186/1476-069X-4-26/fulltext.html http://link.springer.com/content/pdf/10.1186/1476-069X-4-26 https://link.springer.com/content/pdf/10.1186/1476-069X-4-26.pdf |
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crspringernat:10.1186/1476-069x-4-26 2023-05-15T16:30:09+02:00 Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study Toft, Gunnar Axmon, Anna Giwercman, Aleksander Thulstrup, Ane Marie Rignell-Hydbom, Anna Pedersen, Henning Sloth Ludwicki, Jan K Zvyezday, Valentina Zinchuk, Andery Spano, Marcello Manicardi, Gian Carlo Bonefeld-Jørgensen, Eva C Hagmar, Lars Bonde, Jens Peter 2005 http://dx.doi.org/10.1186/1476-069x-4-26 http://link.springer.com/content/pdf/10.1186/1476-069X-4-26.pdf http://link.springer.com/article/10.1186/1476-069X-4-26/fulltext.html http://link.springer.com/content/pdf/10.1186/1476-069X-4-26 https://link.springer.com/content/pdf/10.1186/1476-069X-4-26.pdf en eng Springer Science and Business Media LLC http://www.springer.com/tdm Environmental Health volume 4, issue 1 ISSN 1476-069X Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health journal-article 2005 crspringernat https://doi.org/10.1186/1476-069x-4-26 2022-01-04T16:21:43Z Abstract Background Persistent organochlorine pollutants (POPs) may interfere with reproductive function but direct evidence in humans is very limited. Methods Fertility was examined in four regions with contrasting blood levels of POPs. Pregnant women and their partners in Warsaw (Poland), Kharkiv (Ukraine) and Greenland were consecutively enrolled during antenatal visits. Swedish fishermen and their spouses were recruited separately and independently of current pregnancy. Lipid adjusted serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (DDE) were available for both partners. Time to pregnancy interviews were obtained among 2269 women and 798 men provided a semen sample. Results Inuits had high levels of both POP markers, Swedish fishermen were high in CB-153 but low in DDE, men from Kharkiv were high in DDE and low in CB-153 while men from Warsaw were low in CB-153 and had intermediate DDE levels. Compared to Warsaw couples, fecundability was reduced among couples from Kharkiv [adjusted fecundability ratio (FR) 0.64 (95% CI 0.5–0.8)] and elevated in Swedish fishermen families [FR 1.26 (95% CI 1.0–1.6)]. Adjusted geometric means of sperm counts and morphology did not differ between regions while sperm motility was higher in men living in Warsaw. Conclusion We observed regional differences in time to pregnancy and sperm motility that may be related to regional differences in POP blood levels, but other interpretations are also plausible. In particular, differences in access to safe contraception and in the prevalence of contraceptive failures are most likely to bias comparisons of time to pregnancy. Article in Journal/Newspaper Greenland inuits Springer Nature (via Crossref) Greenland Environmental Health 4 1 |
institution |
Open Polar |
collection |
Springer Nature (via Crossref) |
op_collection_id |
crspringernat |
language |
English |
topic |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
spellingShingle |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toft, Gunnar Axmon, Anna Giwercman, Aleksander Thulstrup, Ane Marie Rignell-Hydbom, Anna Pedersen, Henning Sloth Ludwicki, Jan K Zvyezday, Valentina Zinchuk, Andery Spano, Marcello Manicardi, Gian Carlo Bonefeld-Jørgensen, Eva C Hagmar, Lars Bonde, Jens Peter Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
topic_facet |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
description |
Abstract Background Persistent organochlorine pollutants (POPs) may interfere with reproductive function but direct evidence in humans is very limited. Methods Fertility was examined in four regions with contrasting blood levels of POPs. Pregnant women and their partners in Warsaw (Poland), Kharkiv (Ukraine) and Greenland were consecutively enrolled during antenatal visits. Swedish fishermen and their spouses were recruited separately and independently of current pregnancy. Lipid adjusted serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (DDE) were available for both partners. Time to pregnancy interviews were obtained among 2269 women and 798 men provided a semen sample. Results Inuits had high levels of both POP markers, Swedish fishermen were high in CB-153 but low in DDE, men from Kharkiv were high in DDE and low in CB-153 while men from Warsaw were low in CB-153 and had intermediate DDE levels. Compared to Warsaw couples, fecundability was reduced among couples from Kharkiv [adjusted fecundability ratio (FR) 0.64 (95% CI 0.5–0.8)] and elevated in Swedish fishermen families [FR 1.26 (95% CI 1.0–1.6)]. Adjusted geometric means of sperm counts and morphology did not differ between regions while sperm motility was higher in men living in Warsaw. Conclusion We observed regional differences in time to pregnancy and sperm motility that may be related to regional differences in POP blood levels, but other interpretations are also plausible. In particular, differences in access to safe contraception and in the prevalence of contraceptive failures are most likely to bias comparisons of time to pregnancy. |
format |
Article in Journal/Newspaper |
author |
Toft, Gunnar Axmon, Anna Giwercman, Aleksander Thulstrup, Ane Marie Rignell-Hydbom, Anna Pedersen, Henning Sloth Ludwicki, Jan K Zvyezday, Valentina Zinchuk, Andery Spano, Marcello Manicardi, Gian Carlo Bonefeld-Jørgensen, Eva C Hagmar, Lars Bonde, Jens Peter |
author_facet |
Toft, Gunnar Axmon, Anna Giwercman, Aleksander Thulstrup, Ane Marie Rignell-Hydbom, Anna Pedersen, Henning Sloth Ludwicki, Jan K Zvyezday, Valentina Zinchuk, Andery Spano, Marcello Manicardi, Gian Carlo Bonefeld-Jørgensen, Eva C Hagmar, Lars Bonde, Jens Peter |
author_sort |
Toft, Gunnar |
title |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
title_short |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
title_full |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
title_fullStr |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
title_full_unstemmed |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
title_sort |
fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
publisher |
Springer Science and Business Media LLC |
publishDate |
2005 |
url |
http://dx.doi.org/10.1186/1476-069x-4-26 http://link.springer.com/content/pdf/10.1186/1476-069X-4-26.pdf http://link.springer.com/article/10.1186/1476-069X-4-26/fulltext.html http://link.springer.com/content/pdf/10.1186/1476-069X-4-26 https://link.springer.com/content/pdf/10.1186/1476-069X-4-26.pdf |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuits |
genre_facet |
Greenland inuits |
op_source |
Environmental Health volume 4, issue 1 ISSN 1476-069X |
op_rights |
http://www.springer.com/tdm |
op_doi |
https://doi.org/10.1186/1476-069x-4-26 |
container_title |
Environmental Health |
container_volume |
4 |
container_issue |
1 |
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1766019867957264384 |