Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study
Abstract Background The n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, which are present in fish, are protective against myocardial infarction. However, fish also contains methylmercury, which influences the risk of myocardial infarction, possibly by generating oxida...
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Springer Science and Business Media LLC
2011
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Online Access: | http://dx.doi.org/10.1186/1476-069x-10-33 http://link.springer.com/content/pdf/10.1186/1476-069X-10-33.pdf http://link.springer.com/article/10.1186/1476-069X-10-33/fulltext.html http://link.springer.com/content/pdf/10.1186/1476-069X-10-33 https://link.springer.com/content/pdf/10.1186/1476-069X-10-33.pdf |
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crspringernat:10.1186/1476-069x-10-33 2023-05-15T17:45:14+02:00 Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study Engström, Karin S Wennberg, Maria Strömberg, Ulf Bergdahl, Ingvar A Hallmans, Göran Jansson, Jan-Håkan Lundh, Thomas Norberg, Margareta Rentschler, Gerda Vessby, Bengt Skerfving, Staffan Broberg, Karin 2011 http://dx.doi.org/10.1186/1476-069x-10-33 http://link.springer.com/content/pdf/10.1186/1476-069X-10-33.pdf http://link.springer.com/article/10.1186/1476-069X-10-33/fulltext.html http://link.springer.com/content/pdf/10.1186/1476-069X-10-33 https://link.springer.com/content/pdf/10.1186/1476-069X-10-33.pdf en eng Springer Science and Business Media LLC http://www.springer.com/tdm Environmental Health volume 10, issue 1 ISSN 1476-069X Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health journal-article 2011 crspringernat https://doi.org/10.1186/1476-069x-10-33 2022-01-04T16:17:23Z Abstract Background The n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, which are present in fish, are protective against myocardial infarction. However, fish also contains methylmercury, which influences the risk of myocardial infarction, possibly by generating oxidative stress. Methylmercury is metabolized by conjugation to glutathione, which facilitates elimination. Glutathione is also an antioxidant. Individuals with certain polymorphisms in glutathione-related genes may tolerate higher exposures to methylmercury, due to faster metabolism and elimination and/or better glutathione-associated antioxidative capacity. They would thus benefit more from the protective agents in fish, such as eicosapentaenoic+docosahexaenoic acid and selenium. The objective for this study was to elucidate whether genetic polymorphisms in glutathione-related genes modify the association between eicosapentaenoic+docosahexaenoic acid or methylmercury and risk of first ever myocardial infarction. Methods Polymorphisms in glutathione-synthesizing (glutamyl-cysteine ligase catalytic subunit, GCLC and glutamyl-cysteine ligase modifier subunit, GCLM ) or glutathione-conjugating (glutathione S-transferase P, GSTP1 ) genes were genotyped in 1027 individuals from northern Sweden (458 cases of first-ever myocardial infarction and 569 matched controls). The impact of these polymorphisms on the association between erythrocyte-mercury (proxy for methylmercury) and risk of myocardial infarction, as well as between plasma eicosapentaenoic+docosahexaenoic acid and risk of myocardial infarction, was evaluated by conditional logistic regression. The effect of erythrocyte-selenium on risk of myocardial infarction was also taken into consideration. Results There were no strong genetic modifying effects on the association between plasma eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury and risk of myocardial infarction risk. When eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury were divided into tertiles, individuals with GCLM - 588 TT genotype displayed a lower risk relative to the CC genotype in all but one tertile; in most tertiles the odds ratio was around 0.5 for TT . However, there were few TT carriers and the results were not statistically significant. The results were similar when taking plasma eicosapentaenoic+docosahexaenoic acid, erythrocyte-selenium and erythrocyte-mercury into account simultaneously. Conclusions No statistically significant genetic modifying effects were seen for the association between plasma eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury and risk of myocardial infarction. Still, our results indicate that the relatively rare GCLM - 588 TT genotype may have an impact, but a larger study is necessary for confirmation. Article in Journal/Newspaper Northern Sweden Springer Nature (via Crossref) Environmental Health 10 1 |
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Open Polar |
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Springer Nature (via Crossref) |
op_collection_id |
crspringernat |
language |
English |
topic |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
spellingShingle |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Engström, Karin S Wennberg, Maria Strömberg, Ulf Bergdahl, Ingvar A Hallmans, Göran Jansson, Jan-Håkan Lundh, Thomas Norberg, Margareta Rentschler, Gerda Vessby, Bengt Skerfving, Staffan Broberg, Karin Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
topic_facet |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
description |
Abstract Background The n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, which are present in fish, are protective against myocardial infarction. However, fish also contains methylmercury, which influences the risk of myocardial infarction, possibly by generating oxidative stress. Methylmercury is metabolized by conjugation to glutathione, which facilitates elimination. Glutathione is also an antioxidant. Individuals with certain polymorphisms in glutathione-related genes may tolerate higher exposures to methylmercury, due to faster metabolism and elimination and/or better glutathione-associated antioxidative capacity. They would thus benefit more from the protective agents in fish, such as eicosapentaenoic+docosahexaenoic acid and selenium. The objective for this study was to elucidate whether genetic polymorphisms in glutathione-related genes modify the association between eicosapentaenoic+docosahexaenoic acid or methylmercury and risk of first ever myocardial infarction. Methods Polymorphisms in glutathione-synthesizing (glutamyl-cysteine ligase catalytic subunit, GCLC and glutamyl-cysteine ligase modifier subunit, GCLM ) or glutathione-conjugating (glutathione S-transferase P, GSTP1 ) genes were genotyped in 1027 individuals from northern Sweden (458 cases of first-ever myocardial infarction and 569 matched controls). The impact of these polymorphisms on the association between erythrocyte-mercury (proxy for methylmercury) and risk of myocardial infarction, as well as between plasma eicosapentaenoic+docosahexaenoic acid and risk of myocardial infarction, was evaluated by conditional logistic regression. The effect of erythrocyte-selenium on risk of myocardial infarction was also taken into consideration. Results There were no strong genetic modifying effects on the association between plasma eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury and risk of myocardial infarction risk. When eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury were divided into tertiles, individuals with GCLM - 588 TT genotype displayed a lower risk relative to the CC genotype in all but one tertile; in most tertiles the odds ratio was around 0.5 for TT . However, there were few TT carriers and the results were not statistically significant. The results were similar when taking plasma eicosapentaenoic+docosahexaenoic acid, erythrocyte-selenium and erythrocyte-mercury into account simultaneously. Conclusions No statistically significant genetic modifying effects were seen for the association between plasma eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury and risk of myocardial infarction. Still, our results indicate that the relatively rare GCLM - 588 TT genotype may have an impact, but a larger study is necessary for confirmation. |
format |
Article in Journal/Newspaper |
author |
Engström, Karin S Wennberg, Maria Strömberg, Ulf Bergdahl, Ingvar A Hallmans, Göran Jansson, Jan-Håkan Lundh, Thomas Norberg, Margareta Rentschler, Gerda Vessby, Bengt Skerfving, Staffan Broberg, Karin |
author_facet |
Engström, Karin S Wennberg, Maria Strömberg, Ulf Bergdahl, Ingvar A Hallmans, Göran Jansson, Jan-Håkan Lundh, Thomas Norberg, Margareta Rentschler, Gerda Vessby, Bengt Skerfving, Staffan Broberg, Karin |
author_sort |
Engström, Karin S |
title |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
title_short |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
title_full |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
title_fullStr |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
title_full_unstemmed |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
title_sort |
evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
publisher |
Springer Science and Business Media LLC |
publishDate |
2011 |
url |
http://dx.doi.org/10.1186/1476-069x-10-33 http://link.springer.com/content/pdf/10.1186/1476-069X-10-33.pdf http://link.springer.com/article/10.1186/1476-069X-10-33/fulltext.html http://link.springer.com/content/pdf/10.1186/1476-069X-10-33 https://link.springer.com/content/pdf/10.1186/1476-069X-10-33.pdf |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Environmental Health volume 10, issue 1 ISSN 1476-069X |
op_rights |
http://www.springer.com/tdm |
op_doi |
https://doi.org/10.1186/1476-069x-10-33 |
container_title |
Environmental Health |
container_volume |
10 |
container_issue |
1 |
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1766148102294601728 |