Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination
Abstract Background Halibuts are commercially important flatfish species confined to the North Pacific and North Atlantic Oceans. We have determined the complete mitochondrial genome sequences of four specimens each of Atlantic halibut ( Hippoglossus hippoglossus ), Pacific halibut ( Hippoglossus st...
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crspringernat:10.1186/1471-2164-9-10 2023-05-15T16:29:15+02:00 Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination Mjelle, Kenneth A Karlsen, Bård O Jørgensen, Tor E Moum, Truls Johansen, Steinar D 2008 http://dx.doi.org/10.1186/1471-2164-9-10 https://link.springer.com/content/pdf/10.1186/1471-2164-9-10.pdf en eng Springer Science and Business Media LLC BMC Genomics volume 9, issue 1 ISSN 1471-2164 Genetics Biotechnology journal-article 2008 crspringernat https://doi.org/10.1186/1471-2164-9-10 2022-01-04T16:30:08Z Abstract Background Halibuts are commercially important flatfish species confined to the North Pacific and North Atlantic Oceans. We have determined the complete mitochondrial genome sequences of four specimens each of Atlantic halibut ( Hippoglossus hippoglossus ), Pacific halibut ( Hippoglossus stenolepis ) and Greenland halibut ( Reinhardtius hippoglossoides ), and assessed the nucleotide variability within and between species. Results About 100 variable positions were identified within the four specimens in each halibut species, with the control regions as the most variable parts of the genomes (10 times that of the mitochondrial ribosomal DNA). Due to tandem repeat arrays, the control regions have unusually large sizes compared to most vertebrate mtDNAs. The arrays are highly heteroplasmic in size and consist mainly of different variants of a 61-bp motif. Halibut mitochondrial genomes lacking arrays were also detected. Conclusion The complexity, distribution, and biological role of the heteroplasmic tandem repeat arrays in halibut mitochondrial control regions are discussed. We conclude that the most plausible explanation for array maintenance includes both the slipped-strand mispairing and DNA recombination mechanisms. Article in Journal/Newspaper Greenland North Atlantic Springer Nature (via Crossref) Greenland Pacific BMC Genomics 9 1 |
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Springer Nature (via Crossref) |
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English |
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Genetics Biotechnology |
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Genetics Biotechnology Mjelle, Kenneth A Karlsen, Bård O Jørgensen, Tor E Moum, Truls Johansen, Steinar D Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination |
topic_facet |
Genetics Biotechnology |
description |
Abstract Background Halibuts are commercially important flatfish species confined to the North Pacific and North Atlantic Oceans. We have determined the complete mitochondrial genome sequences of four specimens each of Atlantic halibut ( Hippoglossus hippoglossus ), Pacific halibut ( Hippoglossus stenolepis ) and Greenland halibut ( Reinhardtius hippoglossoides ), and assessed the nucleotide variability within and between species. Results About 100 variable positions were identified within the four specimens in each halibut species, with the control regions as the most variable parts of the genomes (10 times that of the mitochondrial ribosomal DNA). Due to tandem repeat arrays, the control regions have unusually large sizes compared to most vertebrate mtDNAs. The arrays are highly heteroplasmic in size and consist mainly of different variants of a 61-bp motif. Halibut mitochondrial genomes lacking arrays were also detected. Conclusion The complexity, distribution, and biological role of the heteroplasmic tandem repeat arrays in halibut mitochondrial control regions are discussed. We conclude that the most plausible explanation for array maintenance includes both the slipped-strand mispairing and DNA recombination mechanisms. |
format |
Article in Journal/Newspaper |
author |
Mjelle, Kenneth A Karlsen, Bård O Jørgensen, Tor E Moum, Truls Johansen, Steinar D |
author_facet |
Mjelle, Kenneth A Karlsen, Bård O Jørgensen, Tor E Moum, Truls Johansen, Steinar D |
author_sort |
Mjelle, Kenneth A |
title |
Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination |
title_short |
Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination |
title_full |
Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination |
title_fullStr |
Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination |
title_full_unstemmed |
Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination |
title_sort |
halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in dna recombination |
publisher |
Springer Science and Business Media LLC |
publishDate |
2008 |
url |
http://dx.doi.org/10.1186/1471-2164-9-10 https://link.springer.com/content/pdf/10.1186/1471-2164-9-10.pdf |
geographic |
Greenland Pacific |
geographic_facet |
Greenland Pacific |
genre |
Greenland North Atlantic |
genre_facet |
Greenland North Atlantic |
op_source |
BMC Genomics volume 9, issue 1 ISSN 1471-2164 |
op_doi |
https://doi.org/10.1186/1471-2164-9-10 |
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BMC Genomics |
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9 |
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1 |
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