Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe
Abstract Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection dynamics of rodent-borne diseases, such a...
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Online Access: | http://dx.doi.org/10.1038/s41598-021-95000-y https://www.nature.com/articles/s41598-021-95000-y.pdf https://www.nature.com/articles/s41598-021-95000-y |
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crspringernat:10.1038/s41598-021-95000-y 2023-05-15T16:12:05+02:00 Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe Aminikhah, Mahdi Forsman, Jukka T. Koskela, Esa Mappes, Tapio Sane, Jussi Ollgren, Jukka Kivelä, Sami M. Kallio, Eva R. Kvantum Institute at University of Oulu Koneen Säätiö Academy of Finland Terveyden ja hyvinvoinnin laitos 2021 http://dx.doi.org/10.1038/s41598-021-95000-y https://www.nature.com/articles/s41598-021-95000-y.pdf https://www.nature.com/articles/s41598-021-95000-y en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Scientific Reports volume 11, issue 1 ISSN 2045-2322 Multidisciplinary journal-article 2021 crspringernat https://doi.org/10.1038/s41598-021-95000-y 2022-01-04T16:40:04Z Abstract Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection dynamics of rodent-borne diseases, such as diseases caused by hantaviruses. However, the role of rodent population dynamics in determining the infection dynamics of rodent-associated tick-borne diseases, such as Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato bacteria, have gained limited attention in Northern Europe, despite the multiannual abundance fluctuations, the so-called vole cycles, that characterise rodent population dynamics in the region. Here, we quantify the associations between rodent abundance and LB human cases and Puumala Orthohantavirus (PUUV) infections by using two time series (25-year and 9-year) in Finland. Both bank vole ( Myodes glareolus ) abundance as well as LB and PUUV infection incidence in humans showed approximately 3-year cycles. Without vector transmitted PUUV infections followed the bank vole host abundance fluctuations with two-month time lag, whereas tick-transmitted LB was associated with bank vole abundance ca. 12 and 24 months earlier. However, the strength of association between LB incidence and bank vole abundance ca. 12 months before varied over the study years. This study highlights that the human risk to acquire rodent-borne pathogens, as well as rodent-associated tick-borne pathogens is associated with the vole cycles in Northern Fennoscandia, yet with complex time lags. Article in Journal/Newspaper Fennoscandia Springer Nature (via Crossref) Scientific Reports 11 1 |
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Multidisciplinary Aminikhah, Mahdi Forsman, Jukka T. Koskela, Esa Mappes, Tapio Sane, Jussi Ollgren, Jukka Kivelä, Sami M. Kallio, Eva R. Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
topic_facet |
Multidisciplinary |
description |
Abstract Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection dynamics of rodent-borne diseases, such as diseases caused by hantaviruses. However, the role of rodent population dynamics in determining the infection dynamics of rodent-associated tick-borne diseases, such as Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato bacteria, have gained limited attention in Northern Europe, despite the multiannual abundance fluctuations, the so-called vole cycles, that characterise rodent population dynamics in the region. Here, we quantify the associations between rodent abundance and LB human cases and Puumala Orthohantavirus (PUUV) infections by using two time series (25-year and 9-year) in Finland. Both bank vole ( Myodes glareolus ) abundance as well as LB and PUUV infection incidence in humans showed approximately 3-year cycles. Without vector transmitted PUUV infections followed the bank vole host abundance fluctuations with two-month time lag, whereas tick-transmitted LB was associated with bank vole abundance ca. 12 and 24 months earlier. However, the strength of association between LB incidence and bank vole abundance ca. 12 months before varied over the study years. This study highlights that the human risk to acquire rodent-borne pathogens, as well as rodent-associated tick-borne pathogens is associated with the vole cycles in Northern Fennoscandia, yet with complex time lags. |
author2 |
Kvantum Institute at University of Oulu Koneen Säätiö Academy of Finland Terveyden ja hyvinvoinnin laitos |
format |
Article in Journal/Newspaper |
author |
Aminikhah, Mahdi Forsman, Jukka T. Koskela, Esa Mappes, Tapio Sane, Jussi Ollgren, Jukka Kivelä, Sami M. Kallio, Eva R. |
author_facet |
Aminikhah, Mahdi Forsman, Jukka T. Koskela, Esa Mappes, Tapio Sane, Jussi Ollgren, Jukka Kivelä, Sami M. Kallio, Eva R. |
author_sort |
Aminikhah, Mahdi |
title |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_short |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_full |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_fullStr |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_full_unstemmed |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_sort |
rodent host population dynamics drive zoonotic lyme borreliosis and orthohantavirus infections in humans in northern europe |
publisher |
Springer Science and Business Media LLC |
publishDate |
2021 |
url |
http://dx.doi.org/10.1038/s41598-021-95000-y https://www.nature.com/articles/s41598-021-95000-y.pdf https://www.nature.com/articles/s41598-021-95000-y |
genre |
Fennoscandia |
genre_facet |
Fennoscandia |
op_source |
Scientific Reports volume 11, issue 1 ISSN 2045-2322 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-021-95000-y |
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Scientific Reports |
container_volume |
11 |
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1 |
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1765997319146176512 |