Potential natural immunization against atherosclerosis in hibernating bears
Abstract Brown bears ( Ursus arctos ) hibernate for 5–6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) a...
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2021
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crspringernat:10.1038/s41598-021-91679-1 2023-05-15T18:42:10+02:00 Potential natural immunization against atherosclerosis in hibernating bears Samal, Shailesh Kumar Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegård, Johan vetenskapsrådet Karolinska Institute 2021 http://dx.doi.org/10.1038/s41598-021-91679-1 http://www.nature.com/articles/s41598-021-91679-1.pdf http://www.nature.com/articles/s41598-021-91679-1 en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Scientific Reports volume 11, issue 1 ISSN 2045-2322 Multidisciplinary journal-article 2021 crspringernat https://doi.org/10.1038/s41598-021-91679-1 2022-01-04T15:13:58Z Abstract Brown bears ( Ursus arctos ) hibernate for 5–6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated with less atherosclerosis, CVD and mortality in uremia in humans and have anti-inflammatory and other potentially protective properties. PC but not MDA is exposed on different types of microorganisms. We determine anti-PC and anti-MDA in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by enzyme linked immunosorbent assay (ELISA). When determined as arbitrary units (median set at 100 for summer samples), significantly raised levels were observed in winter for anti-PC subclasses and isotypes, and for IgA anti-PC the difference was striking; 100 IQR (85.9–107.9) vs 782.3, IQR (422.8–1586.0; p < 0.001). In contrast, subclasses and isotypes of anti-MDA were significantly lower in winter except IgA anti-MDA, which was not detectable. Anti-PCs are significantly raised during hibernation in brown bears; especially IgA anti-PC was strikingly high. In contrast, anti-MDA titers was decreased during hibernation. Our observation may represent natural immunization with microorganisms during a vulnerable period and could have therapeutic implications for prevention of atherosclerosis. Article in Journal/Newspaper Ursus arctos Springer Nature (via Crossref) Scientific Reports 11 1 |
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Springer Nature (via Crossref) |
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English |
topic |
Multidisciplinary |
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Multidisciplinary Samal, Shailesh Kumar Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegård, Johan Potential natural immunization against atherosclerosis in hibernating bears |
topic_facet |
Multidisciplinary |
description |
Abstract Brown bears ( Ursus arctos ) hibernate for 5–6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated with less atherosclerosis, CVD and mortality in uremia in humans and have anti-inflammatory and other potentially protective properties. PC but not MDA is exposed on different types of microorganisms. We determine anti-PC and anti-MDA in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by enzyme linked immunosorbent assay (ELISA). When determined as arbitrary units (median set at 100 for summer samples), significantly raised levels were observed in winter for anti-PC subclasses and isotypes, and for IgA anti-PC the difference was striking; 100 IQR (85.9–107.9) vs 782.3, IQR (422.8–1586.0; p < 0.001). In contrast, subclasses and isotypes of anti-MDA were significantly lower in winter except IgA anti-MDA, which was not detectable. Anti-PCs are significantly raised during hibernation in brown bears; especially IgA anti-PC was strikingly high. In contrast, anti-MDA titers was decreased during hibernation. Our observation may represent natural immunization with microorganisms during a vulnerable period and could have therapeutic implications for prevention of atherosclerosis. |
author2 |
vetenskapsrådet Karolinska Institute |
format |
Article in Journal/Newspaper |
author |
Samal, Shailesh Kumar Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegård, Johan |
author_facet |
Samal, Shailesh Kumar Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegård, Johan |
author_sort |
Samal, Shailesh Kumar |
title |
Potential natural immunization against atherosclerosis in hibernating bears |
title_short |
Potential natural immunization against atherosclerosis in hibernating bears |
title_full |
Potential natural immunization against atherosclerosis in hibernating bears |
title_fullStr |
Potential natural immunization against atherosclerosis in hibernating bears |
title_full_unstemmed |
Potential natural immunization against atherosclerosis in hibernating bears |
title_sort |
potential natural immunization against atherosclerosis in hibernating bears |
publisher |
Springer Science and Business Media LLC |
publishDate |
2021 |
url |
http://dx.doi.org/10.1038/s41598-021-91679-1 http://www.nature.com/articles/s41598-021-91679-1.pdf http://www.nature.com/articles/s41598-021-91679-1 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
Scientific Reports volume 11, issue 1 ISSN 2045-2322 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-021-91679-1 |
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Scientific Reports |
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11 |
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1 |
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