The chemical defensome of five model teleost fish
Abstract How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antio...
Published in: | Scientific Reports |
---|---|
Main Authors: | , , , , , , |
Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Springer Science and Business Media LLC
2021
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1038/s41598-021-89948-0 http://www.nature.com/articles/s41598-021-89948-0.pdf http://www.nature.com/articles/s41598-021-89948-0 |
id |
crspringernat:10.1038/s41598-021-89948-0 |
---|---|
record_format |
openpolar |
spelling |
crspringernat:10.1038/s41598-021-89948-0 2023-05-15T15:27:19+02:00 The chemical defensome of five model teleost fish Eide, Marta Zhang, Xiaokang Karlsen, Odd André Goldstone, Jared V. Stegeman, John Jonassen, Inge Goksøyr, Anders Norges Forskningsråd National Institutes of Health 2021 http://dx.doi.org/10.1038/s41598-021-89948-0 http://www.nature.com/articles/s41598-021-89948-0.pdf http://www.nature.com/articles/s41598-021-89948-0 en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Scientific Reports volume 11, issue 1 ISSN 2045-2322 Multidisciplinary journal-article 2021 crspringernat https://doi.org/10.1038/s41598-021-89948-0 2022-01-04T16:30:45Z Abstract How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants, and metal- and heat-responsive genes, and is collectively known as the chemical defensome . Teleost fish is the largest group of vertebrate species and can provide valuable insights into the evolution and functional diversity of defensome genes. We have previously shown that the xenosensing pregnane x receptor ( pxr , nr1i2 ) is lost in many teleost species, including Atlantic cod ( Gadus morhua ) and three-spined stickleback ( Gasterosteus aculeatus ), but it is not known if compensatory mechanisms or signaling pathways have evolved in its absence. In this study, we compared the genes comprising the chemical defensome of five fish species that span the teleosteii evolutionary branch often used as model species in toxicological studies and environmental monitoring programs: zebrafish ( Danio rerio ), medaka ( Oryzias latipes ), Atlantic killifish ( Fundulus heteroclitus ), Atlantic cod, and three-spined stickleback. Genome mining revealed evolved differences in the number and composition of defensome genes that can have implication for how these species sense and respond to environmental pollutants, but we did not observe any candidates of compensatory mechanisms or pathways in cod and stickleback in the absence of pxr . The results indicate that knowledge regarding the diversity and function of the defensome will be important for toxicological testing and risk assessment studies. Article in Journal/Newspaper atlantic cod Gadus morhua Springer Nature (via Crossref) Scientific Reports 11 1 |
institution |
Open Polar |
collection |
Springer Nature (via Crossref) |
op_collection_id |
crspringernat |
language |
English |
topic |
Multidisciplinary |
spellingShingle |
Multidisciplinary Eide, Marta Zhang, Xiaokang Karlsen, Odd André Goldstone, Jared V. Stegeman, John Jonassen, Inge Goksøyr, Anders The chemical defensome of five model teleost fish |
topic_facet |
Multidisciplinary |
description |
Abstract How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants, and metal- and heat-responsive genes, and is collectively known as the chemical defensome . Teleost fish is the largest group of vertebrate species and can provide valuable insights into the evolution and functional diversity of defensome genes. We have previously shown that the xenosensing pregnane x receptor ( pxr , nr1i2 ) is lost in many teleost species, including Atlantic cod ( Gadus morhua ) and three-spined stickleback ( Gasterosteus aculeatus ), but it is not known if compensatory mechanisms or signaling pathways have evolved in its absence. In this study, we compared the genes comprising the chemical defensome of five fish species that span the teleosteii evolutionary branch often used as model species in toxicological studies and environmental monitoring programs: zebrafish ( Danio rerio ), medaka ( Oryzias latipes ), Atlantic killifish ( Fundulus heteroclitus ), Atlantic cod, and three-spined stickleback. Genome mining revealed evolved differences in the number and composition of defensome genes that can have implication for how these species sense and respond to environmental pollutants, but we did not observe any candidates of compensatory mechanisms or pathways in cod and stickleback in the absence of pxr . The results indicate that knowledge regarding the diversity and function of the defensome will be important for toxicological testing and risk assessment studies. |
author2 |
Norges Forskningsråd National Institutes of Health |
format |
Article in Journal/Newspaper |
author |
Eide, Marta Zhang, Xiaokang Karlsen, Odd André Goldstone, Jared V. Stegeman, John Jonassen, Inge Goksøyr, Anders |
author_facet |
Eide, Marta Zhang, Xiaokang Karlsen, Odd André Goldstone, Jared V. Stegeman, John Jonassen, Inge Goksøyr, Anders |
author_sort |
Eide, Marta |
title |
The chemical defensome of five model teleost fish |
title_short |
The chemical defensome of five model teleost fish |
title_full |
The chemical defensome of five model teleost fish |
title_fullStr |
The chemical defensome of five model teleost fish |
title_full_unstemmed |
The chemical defensome of five model teleost fish |
title_sort |
chemical defensome of five model teleost fish |
publisher |
Springer Science and Business Media LLC |
publishDate |
2021 |
url |
http://dx.doi.org/10.1038/s41598-021-89948-0 http://www.nature.com/articles/s41598-021-89948-0.pdf http://www.nature.com/articles/s41598-021-89948-0 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
Scientific Reports volume 11, issue 1 ISSN 2045-2322 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-021-89948-0 |
container_title |
Scientific Reports |
container_volume |
11 |
container_issue |
1 |
_version_ |
1766357763014787072 |