The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland
Abstract Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant...
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Springer Science and Business Media LLC
2020
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Online Access: | http://dx.doi.org/10.1038/s41598-020-79132-1 http://www.nature.com/articles/s41598-020-79132-1.pdf http://www.nature.com/articles/s41598-020-79132-1 |
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crspringernat:10.1038/s41598-020-79132-1 2023-05-15T16:25:16+02:00 The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland Overvad, Maria Diaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Senftleber, Ninna Grarup, Niels Hansen, Torben Jørgensen, Marit Eika 2020 http://dx.doi.org/10.1038/s41598-020-79132-1 http://www.nature.com/articles/s41598-020-79132-1.pdf http://www.nature.com/articles/s41598-020-79132-1 en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Scientific Reports volume 10, issue 1 ISSN 2045-2322 Multidisciplinary journal-article 2020 crspringernat https://doi.org/10.1038/s41598-020-79132-1 2022-01-04T09:14:08Z Abstract Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant confers increased risk of CVD. We followed an initial study population of 4127 adults in Greenland who had participated in at least one population-based health survey, in national registers. We used Poisson regression to calculate incidence rate ratios (IRR) of cardiovascular endpoints, comparing participants with and without diabetes and comparing homozygous TBC1D4 carriers with heterozygous carriers and non-carriers combined. Close to 10% had diabetes and age range was 18–96 years (45% male). Of the 3924 participants without prior CVD, 362 (~ 9%) had CVD events during a median follow-up of 10 years. Multivariate IRR for the effect of diabetes on CVD was 1.12 (95% CI: 0.80, 1.57) p = 0.50. Using a recessive genetic model, we compared homozygous TBC1D4 carriers with wildtype and heterozygous carriers combined, with a multivariate IRR of 1.20 (95% CI: 0.69, 2.11) p = 0.52. Neither diabetes nor the TBC1D4 variant significantly increased CVD risk among Inuit in Greenland in adjusted models. Article in Journal/Newspaper Greenland inuit Springer Nature (via Crossref) Greenland Scientific Reports 10 1 |
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Springer Nature (via Crossref) |
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language |
English |
topic |
Multidisciplinary |
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Multidisciplinary Overvad, Maria Diaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Senftleber, Ninna Grarup, Niels Hansen, Torben Jørgensen, Marit Eika The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
topic_facet |
Multidisciplinary |
description |
Abstract Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant confers increased risk of CVD. We followed an initial study population of 4127 adults in Greenland who had participated in at least one population-based health survey, in national registers. We used Poisson regression to calculate incidence rate ratios (IRR) of cardiovascular endpoints, comparing participants with and without diabetes and comparing homozygous TBC1D4 carriers with heterozygous carriers and non-carriers combined. Close to 10% had diabetes and age range was 18–96 years (45% male). Of the 3924 participants without prior CVD, 362 (~ 9%) had CVD events during a median follow-up of 10 years. Multivariate IRR for the effect of diabetes on CVD was 1.12 (95% CI: 0.80, 1.57) p = 0.50. Using a recessive genetic model, we compared homozygous TBC1D4 carriers with wildtype and heterozygous carriers combined, with a multivariate IRR of 1.20 (95% CI: 0.69, 2.11) p = 0.52. Neither diabetes nor the TBC1D4 variant significantly increased CVD risk among Inuit in Greenland in adjusted models. |
format |
Article in Journal/Newspaper |
author |
Overvad, Maria Diaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Senftleber, Ninna Grarup, Niels Hansen, Torben Jørgensen, Marit Eika |
author_facet |
Overvad, Maria Diaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Senftleber, Ninna Grarup, Niels Hansen, Torben Jørgensen, Marit Eika |
author_sort |
Overvad, Maria |
title |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_short |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_full |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_fullStr |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_full_unstemmed |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_sort |
effect of diabetes and the common diabetogenic tbc1d4 p.arg684ter variant on cardiovascular risk in inuit in greenland |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
http://dx.doi.org/10.1038/s41598-020-79132-1 http://www.nature.com/articles/s41598-020-79132-1.pdf http://www.nature.com/articles/s41598-020-79132-1 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_source |
Scientific Reports volume 10, issue 1 ISSN 2045-2322 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-020-79132-1 |
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Scientific Reports |
container_volume |
10 |
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1 |
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1766013990724435968 |