The immune response of bats differs between pre-migration and migration seasons
Abstract Maintaining a competent immune system is energetically costly and thus immunity may be traded against other costly traits such as seasonal migration. Here, we tested in long-distance migratory Nathusius’ pipistrelles ( Pipistrellus nathusii ), if selected branches of immunity are expressed...
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Online Access: | http://dx.doi.org/10.1038/s41598-020-74473-3 https://www.nature.com/articles/s41598-020-74473-3.pdf https://www.nature.com/articles/s41598-020-74473-3 |
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crspringernat:10.1038/s41598-020-74473-3 2023-05-15T17:59:46+02:00 The immune response of bats differs between pre-migration and migration seasons Voigt, Christian C. Fritze, Marcus Lindecke, Oliver Costantini, David Pētersons, Gunārs Czirják, Gábor Á. Projekt DEAL 2020 http://dx.doi.org/10.1038/s41598-020-74473-3 https://www.nature.com/articles/s41598-020-74473-3.pdf https://www.nature.com/articles/s41598-020-74473-3 en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Scientific Reports volume 10, issue 1 ISSN 2045-2322 Multidisciplinary journal-article 2020 crspringernat https://doi.org/10.1038/s41598-020-74473-3 2022-01-04T07:12:11Z Abstract Maintaining a competent immune system is energetically costly and thus immunity may be traded against other costly traits such as seasonal migration. Here, we tested in long-distance migratory Nathusius’ pipistrelles ( Pipistrellus nathusii ), if selected branches of immunity are expressed differently in response to the energy demands and oxidative stress of aerial migration. During the migration period, we observed higher baseline lymphocyte and lower neutrophil levels than during the pre-migration period, but no stronger response of cellular effectors to an antigen challenge. Baseline plasma haptoglobin, as a component of the humoral innate immunity, remained similar during both seasons, yet baseline plasma haptoglobin levels increased by a factor of 7.8 in migratory bats during an immune challenge, whereas they did not change during the pre-migration period. Oxidative stress was higher during migration than during pre-migration, yet there was no association between blood oxidative status and immune parameters, and immune challenge did not trigger any changes in oxidative stress, irrespective of season. Our findings suggest that humoral effectors of the acute phase response may play a stronger role in the first-line defense against infections for migrating bats compared to non-migrating bats. We conclude that Nathusius’ pipistrelles allocate resources differently into the branches of their immune system, most likely following current demands resulting from tight energy budgets during migration. Article in Journal/Newspaper Pipistrellus nathusii Springer Nature (via Crossref) Scientific Reports 10 1 |
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Springer Nature (via Crossref) |
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crspringernat |
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English |
topic |
Multidisciplinary |
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Multidisciplinary Voigt, Christian C. Fritze, Marcus Lindecke, Oliver Costantini, David Pētersons, Gunārs Czirják, Gábor Á. The immune response of bats differs between pre-migration and migration seasons |
topic_facet |
Multidisciplinary |
description |
Abstract Maintaining a competent immune system is energetically costly and thus immunity may be traded against other costly traits such as seasonal migration. Here, we tested in long-distance migratory Nathusius’ pipistrelles ( Pipistrellus nathusii ), if selected branches of immunity are expressed differently in response to the energy demands and oxidative stress of aerial migration. During the migration period, we observed higher baseline lymphocyte and lower neutrophil levels than during the pre-migration period, but no stronger response of cellular effectors to an antigen challenge. Baseline plasma haptoglobin, as a component of the humoral innate immunity, remained similar during both seasons, yet baseline plasma haptoglobin levels increased by a factor of 7.8 in migratory bats during an immune challenge, whereas they did not change during the pre-migration period. Oxidative stress was higher during migration than during pre-migration, yet there was no association between blood oxidative status and immune parameters, and immune challenge did not trigger any changes in oxidative stress, irrespective of season. Our findings suggest that humoral effectors of the acute phase response may play a stronger role in the first-line defense against infections for migrating bats compared to non-migrating bats. We conclude that Nathusius’ pipistrelles allocate resources differently into the branches of their immune system, most likely following current demands resulting from tight energy budgets during migration. |
author2 |
Projekt DEAL |
format |
Article in Journal/Newspaper |
author |
Voigt, Christian C. Fritze, Marcus Lindecke, Oliver Costantini, David Pētersons, Gunārs Czirják, Gábor Á. |
author_facet |
Voigt, Christian C. Fritze, Marcus Lindecke, Oliver Costantini, David Pētersons, Gunārs Czirják, Gábor Á. |
author_sort |
Voigt, Christian C. |
title |
The immune response of bats differs between pre-migration and migration seasons |
title_short |
The immune response of bats differs between pre-migration and migration seasons |
title_full |
The immune response of bats differs between pre-migration and migration seasons |
title_fullStr |
The immune response of bats differs between pre-migration and migration seasons |
title_full_unstemmed |
The immune response of bats differs between pre-migration and migration seasons |
title_sort |
immune response of bats differs between pre-migration and migration seasons |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
http://dx.doi.org/10.1038/s41598-020-74473-3 https://www.nature.com/articles/s41598-020-74473-3.pdf https://www.nature.com/articles/s41598-020-74473-3 |
genre |
Pipistrellus nathusii |
genre_facet |
Pipistrellus nathusii |
op_source |
Scientific Reports volume 10, issue 1 ISSN 2045-2322 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-020-74473-3 |
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Scientific Reports |
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10 |
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1 |
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1766168642268954624 |