Host genetic variation explains reduced protection of commercial vaccines against Piscirickettsia salmonis in Atlantic salmon
Abstract Vaccination is a widely used control strategy to prevent Piscirickettsia salmonis causing disease in salmon farming. However, it is not known why all the currently available commercial vaccines generally fail to protect against this pathogenic bacteria. Here, we report, from two different p...
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Online Access: | http://dx.doi.org/10.1038/s41598-020-70847-9 https://www.nature.com/articles/s41598-020-70847-9.pdf https://www.nature.com/articles/s41598-020-70847-9 |
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crspringernat:10.1038/s41598-020-70847-9 2023-05-15T15:32:26+02:00 Host genetic variation explains reduced protection of commercial vaccines against Piscirickettsia salmonis in Atlantic salmon Figueroa, Carolina Veloso, Pamela Espin, Lenin Dixon, Brian Torrealba, Débora Elalfy, Islam Said Afonso, Juan Manuel Soto, Carlos Conejeros, Pablo Gallardo, José A. Comisión Nacional de Investigación Científica y Tecnológica Pontificia Universidad Católica de Valparaíso Universidad de Valparaíso Agora-Banco Santander's scholarship Cooperative Research Program Fellowship of OECD 2020 http://dx.doi.org/10.1038/s41598-020-70847-9 https://www.nature.com/articles/s41598-020-70847-9.pdf https://www.nature.com/articles/s41598-020-70847-9 en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Scientific Reports volume 10, issue 1 ISSN 2045-2322 Multidisciplinary journal-article 2020 crspringernat https://doi.org/10.1038/s41598-020-70847-9 2022-01-04T07:47:16Z Abstract Vaccination is a widely used control strategy to prevent Piscirickettsia salmonis causing disease in salmon farming. However, it is not known why all the currently available commercial vaccines generally fail to protect against this pathogenic bacteria. Here, we report, from two different populations, that between-family variation is a strong intrinsic factor that determines vaccine protection for this disease. While in some full-sib families, the protection added by vaccination increased the survival time in 13 days in comparison with their unvaccinated siblings; in other families, there was no added protection by vaccination or even it was slightly negative. Resistance to P. salmonis, measured as days to death, was higher in vaccinated than unvaccinated fish, but only a moderate positive genetic correlation was obtained between these traits. This disputes a previous hypothesis, that stated that both traits were fully controlled by the same genes, and challenges the use of unvaccinated fish as gold standard for evaluating and selecting fish resistant to P. salmonis , particularly if the offspring will be vaccinated. More studies are necessary to evaluate if variation in the host immune response to vaccination could explain the between-family differences in resistance observed in vaccinated fish. Article in Journal/Newspaper Atlantic salmon Springer Nature (via Crossref) Scientific Reports 10 1 |
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Springer Nature (via Crossref) |
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English |
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Multidisciplinary Figueroa, Carolina Veloso, Pamela Espin, Lenin Dixon, Brian Torrealba, Débora Elalfy, Islam Said Afonso, Juan Manuel Soto, Carlos Conejeros, Pablo Gallardo, José A. Host genetic variation explains reduced protection of commercial vaccines against Piscirickettsia salmonis in Atlantic salmon |
topic_facet |
Multidisciplinary |
description |
Abstract Vaccination is a widely used control strategy to prevent Piscirickettsia salmonis causing disease in salmon farming. However, it is not known why all the currently available commercial vaccines generally fail to protect against this pathogenic bacteria. Here, we report, from two different populations, that between-family variation is a strong intrinsic factor that determines vaccine protection for this disease. While in some full-sib families, the protection added by vaccination increased the survival time in 13 days in comparison with their unvaccinated siblings; in other families, there was no added protection by vaccination or even it was slightly negative. Resistance to P. salmonis, measured as days to death, was higher in vaccinated than unvaccinated fish, but only a moderate positive genetic correlation was obtained between these traits. This disputes a previous hypothesis, that stated that both traits were fully controlled by the same genes, and challenges the use of unvaccinated fish as gold standard for evaluating and selecting fish resistant to P. salmonis , particularly if the offspring will be vaccinated. More studies are necessary to evaluate if variation in the host immune response to vaccination could explain the between-family differences in resistance observed in vaccinated fish. |
author2 |
Comisión Nacional de Investigación Científica y Tecnológica Pontificia Universidad Católica de Valparaíso Universidad de Valparaíso Agora-Banco Santander's scholarship Cooperative Research Program Fellowship of OECD |
format |
Article in Journal/Newspaper |
author |
Figueroa, Carolina Veloso, Pamela Espin, Lenin Dixon, Brian Torrealba, Débora Elalfy, Islam Said Afonso, Juan Manuel Soto, Carlos Conejeros, Pablo Gallardo, José A. |
author_facet |
Figueroa, Carolina Veloso, Pamela Espin, Lenin Dixon, Brian Torrealba, Débora Elalfy, Islam Said Afonso, Juan Manuel Soto, Carlos Conejeros, Pablo Gallardo, José A. |
author_sort |
Figueroa, Carolina |
title |
Host genetic variation explains reduced protection of commercial vaccines against Piscirickettsia salmonis in Atlantic salmon |
title_short |
Host genetic variation explains reduced protection of commercial vaccines against Piscirickettsia salmonis in Atlantic salmon |
title_full |
Host genetic variation explains reduced protection of commercial vaccines against Piscirickettsia salmonis in Atlantic salmon |
title_fullStr |
Host genetic variation explains reduced protection of commercial vaccines against Piscirickettsia salmonis in Atlantic salmon |
title_full_unstemmed |
Host genetic variation explains reduced protection of commercial vaccines against Piscirickettsia salmonis in Atlantic salmon |
title_sort |
host genetic variation explains reduced protection of commercial vaccines against piscirickettsia salmonis in atlantic salmon |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
http://dx.doi.org/10.1038/s41598-020-70847-9 https://www.nature.com/articles/s41598-020-70847-9.pdf https://www.nature.com/articles/s41598-020-70847-9 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Scientific Reports volume 10, issue 1 ISSN 2045-2322 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-020-70847-9 |
container_title |
Scientific Reports |
container_volume |
10 |
container_issue |
1 |
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1766362935667458048 |