Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos)
Abstract During six months of annual hibernation, the brown bear undergoes unique physiological changes to adapt to decreased metabolic rate. We compared cardiac structural and functional measures of hibernating and active bears using comprehensive echocardiography. We performed echocardiography on...
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Springer Science and Business Media LLC
2020
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Online Access: | http://dx.doi.org/10.1038/s41598-019-57126-y http://www.nature.com/articles/s41598-019-57126-y.pdf http://www.nature.com/articles/s41598-019-57126-y |
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crspringernat:10.1038/s41598-019-57126-y 2023-05-15T18:41:53+02:00 Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos) Jørgensen, Peter Godsk Evans, Alina Kindberg, Jonas Olsen, Lisbeth Høier Galatius, Søren Fröbert, Ole 2020 http://dx.doi.org/10.1038/s41598-019-57126-y http://www.nature.com/articles/s41598-019-57126-y.pdf http://www.nature.com/articles/s41598-019-57126-y en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Scientific Reports volume 10, issue 1 ISSN 2045-2322 Multidisciplinary journal-article 2020 crspringernat https://doi.org/10.1038/s41598-019-57126-y 2022-01-04T16:58:18Z Abstract During six months of annual hibernation, the brown bear undergoes unique physiological changes to adapt to decreased metabolic rate. We compared cardiac structural and functional measures of hibernating and active bears using comprehensive echocardiography. We performed echocardiography on 13 subadult free-ranging, anaesthetised Scandinavian brown bears ( Ursus arctos ) during late hibernation and in early summer. Mean heart rate was 26 beats per minute (standard deviation (SD): 8) during hibernation vs 71 (SD: 14) during active state. All left ventricular (LV) systolic and diastolic measures were decreased during hibernation: mean ejection fraction: 44.2% (SD: 6.0) active state vs 34.0 (SD: 8.1) hibernation, P = 0.001; global longitudinal strain: −11.2% (SD: 2.0) vs −8.8 (SD: 3.3), P = 0.03; global longitudinal strain rate: −0.82 (SD: 0.15) vs −0.41 (SD: 0.18), P < 0.001; septal e’: 9.8 cm/s (SD: 1.8) vs 5.2 (SD: 2.7), P < 0.001. In general, measures of total myocardial motion (ejection fraction and global longitudinal strain) were decreased to a lesser extent than measures of myocardial velocities. In the hibernating brown bear, cardiac adaptation included decreased functional measures, primarily measures of myocardial velocities, but was not associated with cardiac atrophy. Understanding the mechanisms of these adaptations could provide pathophysiological insight of human pathological conditions such as heart failure. Article in Journal/Newspaper Ursus arctos Springer Nature (via Crossref) Scientific Reports 10 1 |
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Springer Nature (via Crossref) |
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English |
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Multidisciplinary |
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Multidisciplinary Jørgensen, Peter Godsk Evans, Alina Kindberg, Jonas Olsen, Lisbeth Høier Galatius, Søren Fröbert, Ole Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos) |
topic_facet |
Multidisciplinary |
description |
Abstract During six months of annual hibernation, the brown bear undergoes unique physiological changes to adapt to decreased metabolic rate. We compared cardiac structural and functional measures of hibernating and active bears using comprehensive echocardiography. We performed echocardiography on 13 subadult free-ranging, anaesthetised Scandinavian brown bears ( Ursus arctos ) during late hibernation and in early summer. Mean heart rate was 26 beats per minute (standard deviation (SD): 8) during hibernation vs 71 (SD: 14) during active state. All left ventricular (LV) systolic and diastolic measures were decreased during hibernation: mean ejection fraction: 44.2% (SD: 6.0) active state vs 34.0 (SD: 8.1) hibernation, P = 0.001; global longitudinal strain: −11.2% (SD: 2.0) vs −8.8 (SD: 3.3), P = 0.03; global longitudinal strain rate: −0.82 (SD: 0.15) vs −0.41 (SD: 0.18), P < 0.001; septal e’: 9.8 cm/s (SD: 1.8) vs 5.2 (SD: 2.7), P < 0.001. In general, measures of total myocardial motion (ejection fraction and global longitudinal strain) were decreased to a lesser extent than measures of myocardial velocities. In the hibernating brown bear, cardiac adaptation included decreased functional measures, primarily measures of myocardial velocities, but was not associated with cardiac atrophy. Understanding the mechanisms of these adaptations could provide pathophysiological insight of human pathological conditions such as heart failure. |
format |
Article in Journal/Newspaper |
author |
Jørgensen, Peter Godsk Evans, Alina Kindberg, Jonas Olsen, Lisbeth Høier Galatius, Søren Fröbert, Ole |
author_facet |
Jørgensen, Peter Godsk Evans, Alina Kindberg, Jonas Olsen, Lisbeth Høier Galatius, Søren Fröbert, Ole |
author_sort |
Jørgensen, Peter Godsk |
title |
Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos) |
title_short |
Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos) |
title_full |
Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos) |
title_fullStr |
Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos) |
title_full_unstemmed |
Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos) |
title_sort |
cardiac adaptation in hibernating, free-ranging scandinavian brown bears (ursus arctos) |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
http://dx.doi.org/10.1038/s41598-019-57126-y http://www.nature.com/articles/s41598-019-57126-y.pdf http://www.nature.com/articles/s41598-019-57126-y |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
Scientific Reports volume 10, issue 1 ISSN 2045-2322 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-019-57126-y |
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Scientific Reports |
container_volume |
10 |
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1 |
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1766231453102768128 |