Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color
Abstract Red coloration of muscle tissue (flesh) is a unique trait in several salmonid genera, including Atlantic salmon. The color results from dietary carotenoids deposited in the flesh, whereas the color intensity is affected both by diet and genetic components. Herein we report on a genome-wide...
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Online Access: | http://dx.doi.org/10.1038/s41598-019-56438-3 http://www.nature.com/articles/s41598-019-56438-3.pdf http://www.nature.com/articles/s41598-019-56438-3 |
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crspringernat:10.1038/s41598-019-56438-3 2023-05-15T15:32:21+02:00 Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color Helgeland, Hanna Sodeland, Marte Zoric, Nina Torgersen, Jacob Seilø Grammes, Fabian von Lintig, Johannes Moen, Thomas Kjøglum, Sissel Lien, Sigbjørn Våge, Dag Inge 2019 http://dx.doi.org/10.1038/s41598-019-56438-3 http://www.nature.com/articles/s41598-019-56438-3.pdf http://www.nature.com/articles/s41598-019-56438-3 en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Scientific Reports volume 9, issue 1 ISSN 2045-2322 Multidisciplinary journal-article 2019 crspringernat https://doi.org/10.1038/s41598-019-56438-3 2022-01-04T16:16:22Z Abstract Red coloration of muscle tissue (flesh) is a unique trait in several salmonid genera, including Atlantic salmon. The color results from dietary carotenoids deposited in the flesh, whereas the color intensity is affected both by diet and genetic components. Herein we report on a genome-wide association study (GWAS) to identify genetic variation underlying this trait. Two SNPs on ssa26 showed strong associations to the flesh color in salmon. Two genes known to be involved in carotenoid metabolism were located in this QTL- region: beta-carotene oxygenase 1 ( bco1 ) and beta-carotene oxygenase 1 like ( bco1l ). To determine whether flesh color variation is caused by one, or both, of these genes, functional studies were carried out including mRNA and protein expression in fish with red and pale flesh color. The catalytic abilities of these two genes were also tested with different carotenoids. Our results suggest bco1l to be the most likely gene to explain the flesh color variation observed in this population. Article in Journal/Newspaper Atlantic salmon Springer Nature (via Crossref) Scientific Reports 9 1 |
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Springer Nature (via Crossref) |
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English |
topic |
Multidisciplinary |
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Multidisciplinary Helgeland, Hanna Sodeland, Marte Zoric, Nina Torgersen, Jacob Seilø Grammes, Fabian von Lintig, Johannes Moen, Thomas Kjøglum, Sissel Lien, Sigbjørn Våge, Dag Inge Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
topic_facet |
Multidisciplinary |
description |
Abstract Red coloration of muscle tissue (flesh) is a unique trait in several salmonid genera, including Atlantic salmon. The color results from dietary carotenoids deposited in the flesh, whereas the color intensity is affected both by diet and genetic components. Herein we report on a genome-wide association study (GWAS) to identify genetic variation underlying this trait. Two SNPs on ssa26 showed strong associations to the flesh color in salmon. Two genes known to be involved in carotenoid metabolism were located in this QTL- region: beta-carotene oxygenase 1 ( bco1 ) and beta-carotene oxygenase 1 like ( bco1l ). To determine whether flesh color variation is caused by one, or both, of these genes, functional studies were carried out including mRNA and protein expression in fish with red and pale flesh color. The catalytic abilities of these two genes were also tested with different carotenoids. Our results suggest bco1l to be the most likely gene to explain the flesh color variation observed in this population. |
format |
Article in Journal/Newspaper |
author |
Helgeland, Hanna Sodeland, Marte Zoric, Nina Torgersen, Jacob Seilø Grammes, Fabian von Lintig, Johannes Moen, Thomas Kjøglum, Sissel Lien, Sigbjørn Våge, Dag Inge |
author_facet |
Helgeland, Hanna Sodeland, Marte Zoric, Nina Torgersen, Jacob Seilø Grammes, Fabian von Lintig, Johannes Moen, Thomas Kjøglum, Sissel Lien, Sigbjørn Våge, Dag Inge |
author_sort |
Helgeland, Hanna |
title |
Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
title_short |
Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
title_full |
Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
title_fullStr |
Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
title_full_unstemmed |
Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
title_sort |
genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
publisher |
Springer Science and Business Media LLC |
publishDate |
2019 |
url |
http://dx.doi.org/10.1038/s41598-019-56438-3 http://www.nature.com/articles/s41598-019-56438-3.pdf http://www.nature.com/articles/s41598-019-56438-3 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Scientific Reports volume 9, issue 1 ISSN 2045-2322 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-019-56438-3 |
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Scientific Reports |
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9 |
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1 |
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1766362857069346816 |