GWAS studies reveal a possible genetic link between cancer and suicide attempt
Abstract Inuit is the population with the highest incidence of suicide attempt and cancer in the world. Previous studies reported that people attempted suicide have a higher future risk for cancer. In view of these data, the largest available genome wide association studies (GWAS) for four major men...
Published in: | Scientific Reports |
---|---|
Main Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Springer Science and Business Media LLC
2019
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1038/s41598-019-54812-9 http://www.nature.com/articles/s41598-019-54812-9.pdf http://www.nature.com/articles/s41598-019-54812-9 |
id |
crspringernat:10.1038/s41598-019-54812-9 |
---|---|
record_format |
openpolar |
spelling |
crspringernat:10.1038/s41598-019-54812-9 2023-05-15T16:55:11+02:00 GWAS studies reveal a possible genetic link between cancer and suicide attempt Voskarides, Konstantinos Chatzittofis, Andreas 2019 http://dx.doi.org/10.1038/s41598-019-54812-9 http://www.nature.com/articles/s41598-019-54812-9.pdf http://www.nature.com/articles/s41598-019-54812-9 en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Scientific Reports volume 9, issue 1 ISSN 2045-2322 Multidisciplinary journal-article 2019 crspringernat https://doi.org/10.1038/s41598-019-54812-9 2022-01-04T16:58:33Z Abstract Inuit is the population with the highest incidence of suicide attempt and cancer in the world. Previous studies reported that people attempted suicide have a higher future risk for cancer. In view of these data, the largest available genome wide association studies (GWAS) for four major mental disorder groups were screened here for any common genes with all known cancer associated genes and oncogenes/tumor suppressor genes. A common genetic background came out only between suicide attempt and cancer (cancer associated genes analysis: RR = 1.64, p = 7.83 × 10 −5 oncogenes/tumor suppressor genes analysis: RR = 2.55, p = 2.82 × 10 −22 ), this supporting existing epidemiological data. Incidence/prevalence of both conditions was found to correlate with extreme cold geographical regions (adjusted R 2 = 0.135, p = 3.00 × 10 −4 ); this is not the case for other mental disorders. Our results show a possible genetic link between suicide attempt and cancer and a possible evolutionary connection of both diseases with extreme cold environments. These data are useful for future molecular studies or even for investigation of possible therapeutic protocols. Article in Journal/Newspaper inuit Springer Nature (via Crossref) Scientific Reports 9 1 |
institution |
Open Polar |
collection |
Springer Nature (via Crossref) |
op_collection_id |
crspringernat |
language |
English |
topic |
Multidisciplinary |
spellingShingle |
Multidisciplinary Voskarides, Konstantinos Chatzittofis, Andreas GWAS studies reveal a possible genetic link between cancer and suicide attempt |
topic_facet |
Multidisciplinary |
description |
Abstract Inuit is the population with the highest incidence of suicide attempt and cancer in the world. Previous studies reported that people attempted suicide have a higher future risk for cancer. In view of these data, the largest available genome wide association studies (GWAS) for four major mental disorder groups were screened here for any common genes with all known cancer associated genes and oncogenes/tumor suppressor genes. A common genetic background came out only between suicide attempt and cancer (cancer associated genes analysis: RR = 1.64, p = 7.83 × 10 −5 oncogenes/tumor suppressor genes analysis: RR = 2.55, p = 2.82 × 10 −22 ), this supporting existing epidemiological data. Incidence/prevalence of both conditions was found to correlate with extreme cold geographical regions (adjusted R 2 = 0.135, p = 3.00 × 10 −4 ); this is not the case for other mental disorders. Our results show a possible genetic link between suicide attempt and cancer and a possible evolutionary connection of both diseases with extreme cold environments. These data are useful for future molecular studies or even for investigation of possible therapeutic protocols. |
format |
Article in Journal/Newspaper |
author |
Voskarides, Konstantinos Chatzittofis, Andreas |
author_facet |
Voskarides, Konstantinos Chatzittofis, Andreas |
author_sort |
Voskarides, Konstantinos |
title |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_short |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_full |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_fullStr |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_full_unstemmed |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_sort |
gwas studies reveal a possible genetic link between cancer and suicide attempt |
publisher |
Springer Science and Business Media LLC |
publishDate |
2019 |
url |
http://dx.doi.org/10.1038/s41598-019-54812-9 http://www.nature.com/articles/s41598-019-54812-9.pdf http://www.nature.com/articles/s41598-019-54812-9 |
genre |
inuit |
genre_facet |
inuit |
op_source |
Scientific Reports volume 9, issue 1 ISSN 2045-2322 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-019-54812-9 |
container_title |
Scientific Reports |
container_volume |
9 |
container_issue |
1 |
_version_ |
1766046173742759936 |