COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside
Abstract This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson’s disease. Major points include that neuropathology...
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2020
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Online Access: | http://dx.doi.org/10.1038/s41531-020-00123-0 https://www.nature.com/articles/s41531-020-00123-0.pdf https://www.nature.com/articles/s41531-020-00123-0 |
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crspringernat:10.1038/s41531-020-00123-0 2023-05-15T15:34:30+02:00 COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside Sulzer, David Antonini, Angelo Leta, Valentina Nordvig, Anna Smeyne, Richard J. Goldman, James E. Al-Dalahmah, Osama Zecca, Luigi Sette, Alessandro Bubacco, Luigi Meucci, Olimpia Moro, Elena Harms, Ashley S. Xu, Yaqian Fahn, Stanley Ray Chaudhuri, K. 2020 http://dx.doi.org/10.1038/s41531-020-00123-0 https://www.nature.com/articles/s41531-020-00123-0.pdf https://www.nature.com/articles/s41531-020-00123-0 en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY npj Parkinson's Disease volume 6, issue 1 ISSN 2373-8057 Cellular and Molecular Neuroscience Clinical Neurology Neurology journal-article 2020 crspringernat https://doi.org/10.1038/s41531-020-00123-0 2022-01-04T15:43:55Z Abstract This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson’s disease. Major points include that neuropathology studies have not answered the central issue of whether the virus enters central nervous system neurons, astrocytes or microglia, and the brain vascular cell types that express virus have not yet been identified. Currently, there is no clear evidence for human neuronal or astrocyte expression of angiotensin-converting enzyme 2 (ACE2), the major receptor for viral entry, but ACE2 expression may be activated by inflammation, and a comparison of healthy and infected brains is important. In contrast to the 1918 influenza pandemic and avian flu, reports of encephalopathy in COVID-19 have been slow to emerge, and there are so far no documented reports of parkinsonism apart from a single case report. We recommend consensus guidelines for the clinical treatment of Parkinson’s patients with COVID-19. While a role for the virus in causing or exacerbating Parkinson’s disease appears unlikely at this time, aggravation of specific motor and non-motor symptoms has been reported, and it will be important to monitor subjects after recovery, particularly for those with persisting hyposmia. Article in Journal/Newspaper Avian flu Springer Nature (via Crossref) npj Parkinson's Disease 6 1 |
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Open Polar |
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Springer Nature (via Crossref) |
op_collection_id |
crspringernat |
language |
English |
topic |
Cellular and Molecular Neuroscience Clinical Neurology Neurology |
spellingShingle |
Cellular and Molecular Neuroscience Clinical Neurology Neurology Sulzer, David Antonini, Angelo Leta, Valentina Nordvig, Anna Smeyne, Richard J. Goldman, James E. Al-Dalahmah, Osama Zecca, Luigi Sette, Alessandro Bubacco, Luigi Meucci, Olimpia Moro, Elena Harms, Ashley S. Xu, Yaqian Fahn, Stanley Ray Chaudhuri, K. COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside |
topic_facet |
Cellular and Molecular Neuroscience Clinical Neurology Neurology |
description |
Abstract This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson’s disease. Major points include that neuropathology studies have not answered the central issue of whether the virus enters central nervous system neurons, astrocytes or microglia, and the brain vascular cell types that express virus have not yet been identified. Currently, there is no clear evidence for human neuronal or astrocyte expression of angiotensin-converting enzyme 2 (ACE2), the major receptor for viral entry, but ACE2 expression may be activated by inflammation, and a comparison of healthy and infected brains is important. In contrast to the 1918 influenza pandemic and avian flu, reports of encephalopathy in COVID-19 have been slow to emerge, and there are so far no documented reports of parkinsonism apart from a single case report. We recommend consensus guidelines for the clinical treatment of Parkinson’s patients with COVID-19. While a role for the virus in causing or exacerbating Parkinson’s disease appears unlikely at this time, aggravation of specific motor and non-motor symptoms has been reported, and it will be important to monitor subjects after recovery, particularly for those with persisting hyposmia. |
format |
Article in Journal/Newspaper |
author |
Sulzer, David Antonini, Angelo Leta, Valentina Nordvig, Anna Smeyne, Richard J. Goldman, James E. Al-Dalahmah, Osama Zecca, Luigi Sette, Alessandro Bubacco, Luigi Meucci, Olimpia Moro, Elena Harms, Ashley S. Xu, Yaqian Fahn, Stanley Ray Chaudhuri, K. |
author_facet |
Sulzer, David Antonini, Angelo Leta, Valentina Nordvig, Anna Smeyne, Richard J. Goldman, James E. Al-Dalahmah, Osama Zecca, Luigi Sette, Alessandro Bubacco, Luigi Meucci, Olimpia Moro, Elena Harms, Ashley S. Xu, Yaqian Fahn, Stanley Ray Chaudhuri, K. |
author_sort |
Sulzer, David |
title |
COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside |
title_short |
COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside |
title_full |
COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside |
title_fullStr |
COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside |
title_full_unstemmed |
COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside |
title_sort |
covid-19 and possible links with parkinson’s disease and parkinsonism: from bench to bedside |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
http://dx.doi.org/10.1038/s41531-020-00123-0 https://www.nature.com/articles/s41531-020-00123-0.pdf https://www.nature.com/articles/s41531-020-00123-0 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_source |
npj Parkinson's Disease volume 6, issue 1 ISSN 2373-8057 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41531-020-00123-0 |
container_title |
npj Parkinson's Disease |
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6 |
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1 |
_version_ |
1766364868982603776 |