Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons
Abstract Studies of animals and plants suggest that nutritional conditions in one generation may affect phenotypic characteristics in subsequent generations. A small number of human studies claim to show that pre-pubertal nutritional experience trigger a sex-specific transgenerational response along...
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Online Access: | http://dx.doi.org/10.1038/s41467-018-07617-9 http://www.nature.com/articles/s41467-018-07617-9.pdf http://www.nature.com/articles/s41467-018-07617-9 |
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crspringernat:10.1038/s41467-018-07617-9 2023-05-15T17:44:37+02:00 Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons Vågerö, Denny Pinger, Pia R. Aronsson, Vanda van den Berg, Gerard J. 2018 http://dx.doi.org/10.1038/s41467-018-07617-9 http://www.nature.com/articles/s41467-018-07617-9.pdf http://www.nature.com/articles/s41467-018-07617-9 en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Nature Communications volume 9, issue 1 ISSN 2041-1723 General Physics and Astronomy General Biochemistry, Genetics and Molecular Biology General Chemistry journal-article 2018 crspringernat https://doi.org/10.1038/s41467-018-07617-9 2022-01-04T07:14:34Z Abstract Studies of animals and plants suggest that nutritional conditions in one generation may affect phenotypic characteristics in subsequent generations. A small number of human studies claim to show that pre-pubertal nutritional experience trigger a sex-specific transgenerational response along the male line. A single historical dataset, the Överkalix cohorts in northern Sweden, is often quoted as evidence. To test this hypothesis on an almost 40 times larger dataset we collect harvest data during the pre-pubertal period of grandparents (G0, n = 9,039) to examine its potential association with mortality in children (G1, n = 7,280) and grandchildren (G2, n = 11,561) in the Uppsala Multigeneration Study. We find support for the main Överkalix finding: paternal grandfather’s food access in pre-puberty predicts his male, but not female, grandchildren’s all-cause mortality. In our study, cancer mortality contributes strongly to this pattern. We are unable to reproduce previous results for diabetes and cardiovascular mortality. Article in Journal/Newspaper Northern Sweden Överkalix Springer Nature (via Crossref) Överkalix ENVELOPE(22.843,22.843,66.327,66.327) Nature Communications 9 1 |
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Open Polar |
collection |
Springer Nature (via Crossref) |
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crspringernat |
language |
English |
topic |
General Physics and Astronomy General Biochemistry, Genetics and Molecular Biology General Chemistry |
spellingShingle |
General Physics and Astronomy General Biochemistry, Genetics and Molecular Biology General Chemistry Vågerö, Denny Pinger, Pia R. Aronsson, Vanda van den Berg, Gerard J. Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
topic_facet |
General Physics and Astronomy General Biochemistry, Genetics and Molecular Biology General Chemistry |
description |
Abstract Studies of animals and plants suggest that nutritional conditions in one generation may affect phenotypic characteristics in subsequent generations. A small number of human studies claim to show that pre-pubertal nutritional experience trigger a sex-specific transgenerational response along the male line. A single historical dataset, the Överkalix cohorts in northern Sweden, is often quoted as evidence. To test this hypothesis on an almost 40 times larger dataset we collect harvest data during the pre-pubertal period of grandparents (G0, n = 9,039) to examine its potential association with mortality in children (G1, n = 7,280) and grandchildren (G2, n = 11,561) in the Uppsala Multigeneration Study. We find support for the main Överkalix finding: paternal grandfather’s food access in pre-puberty predicts his male, but not female, grandchildren’s all-cause mortality. In our study, cancer mortality contributes strongly to this pattern. We are unable to reproduce previous results for diabetes and cardiovascular mortality. |
format |
Article in Journal/Newspaper |
author |
Vågerö, Denny Pinger, Pia R. Aronsson, Vanda van den Berg, Gerard J. |
author_facet |
Vågerö, Denny Pinger, Pia R. Aronsson, Vanda van den Berg, Gerard J. |
author_sort |
Vågerö, Denny |
title |
Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
title_short |
Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
title_full |
Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
title_fullStr |
Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
title_full_unstemmed |
Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
title_sort |
paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
publisher |
Springer Science and Business Media LLC |
publishDate |
2018 |
url |
http://dx.doi.org/10.1038/s41467-018-07617-9 http://www.nature.com/articles/s41467-018-07617-9.pdf http://www.nature.com/articles/s41467-018-07617-9 |
long_lat |
ENVELOPE(22.843,22.843,66.327,66.327) |
geographic |
Överkalix |
geographic_facet |
Överkalix |
genre |
Northern Sweden Överkalix |
genre_facet |
Northern Sweden Överkalix |
op_source |
Nature Communications volume 9, issue 1 ISSN 2041-1723 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41467-018-07617-9 |
container_title |
Nature Communications |
container_volume |
9 |
container_issue |
1 |
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1766146875454390272 |