Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study
Abstract Multiple myeloma (MM) patients have increased risk of severe coronavirus disease 2019 (COVID-19) when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Monoclonal gammopathy of undetermined significance (MGUS), the precursor of MM has been associated with immune dysf...
Published in: | Blood Cancer Journal |
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2021
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Online Access: | http://dx.doi.org/10.1038/s41408-021-00580-7 https://www.nature.com/articles/s41408-021-00580-7.pdf https://www.nature.com/articles/s41408-021-00580-7 |
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crspringernat:10.1038/s41408-021-00580-7 2023-05-15T16:51:04+02:00 Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study Rognvaldsson, Saemundur Eythorsson, Elias Thorsteinsdottir, Sigrun Vidarsson, Brynjar Onundarson, Pall Torfi Agnarsson, Bjarni A. Sigurdardottir, Margret Thorsteinsdóttir, Ingunn Olafsson, Isleifur Runolfsdottir, Hrafnhildur L. Helgason, Dadi Emilsdottir, Arna R. Agustsson, Arnar S. Bjornsson, Aron H. Kristjansdottir, Gudrun Thordardottir, Asdis Rosa Indridason, Olafur Skuli Jonsson, Asbjorn Gislason, Gauti Kjartan Olafsson, Andri Steingrimsdottir, Hlif Kampanis, Petros Hultcrantz, Malin Durie, Brian G. M. Harding, Stephen Landgren, Ola Palsson, Runolfur Love, Thorvarður Jon Kristinsson, Sigurdur Yngvi 2021 http://dx.doi.org/10.1038/s41408-021-00580-7 https://www.nature.com/articles/s41408-021-00580-7.pdf https://www.nature.com/articles/s41408-021-00580-7 en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Blood Cancer Journal volume 11, issue 12 ISSN 2044-5385 Oncology Hematology journal-article 2021 crspringernat https://doi.org/10.1038/s41408-021-00580-7 2022-01-04T07:18:05Z Abstract Multiple myeloma (MM) patients have increased risk of severe coronavirus disease 2019 (COVID-19) when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Monoclonal gammopathy of undetermined significance (MGUS), the precursor of MM has been associated with immune dysfunction which may lead to severe COVID-19. No systematic data have been published on COVID-19 in individuals with MGUS. We conducted a large population-based cohort study evaluating the risk of SARS-CoV-2 infection and severe COVID-19 among individuals with MGUS. We included 75,422 Icelanders born before 1976, who had been screened for MGUS in the Iceland Screens Treats or Prevents Multiple Myeloma study (iStopMM). Data on SARS-CoV-2 testing and COVID-19 severity were acquired from the Icelandic COVID-19 Study Group. Using a test-negative study design, we included 32,047 iStopMM participants who had been tested for SARS-CoV-2, of whom 1754 had MGUS. Among these participants, 1100 participants, tested positive, 65 of whom had MGUS. Severe COVID-19 developed in 230 participants, including 16 with MGUS. MGUS was not associated with SARS-CoV-2 infection (Odds ratio (OR): 1.05; 95% confidence interval (CI): 0.81–1.36; p = 0.72) or severe COVID-19 (OR: 0.99; 95%CI: 0.52–1.91; p = 0.99). These findings indicate that MGUS does not affect the susceptibility to SARS-CoV-2 or the severity of COVID-19. Article in Journal/Newspaper Iceland Springer Nature (via Crossref) Blood Cancer Journal 11 12 |
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Springer Nature (via Crossref) |
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English |
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Oncology Hematology |
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Oncology Hematology Rognvaldsson, Saemundur Eythorsson, Elias Thorsteinsdottir, Sigrun Vidarsson, Brynjar Onundarson, Pall Torfi Agnarsson, Bjarni A. Sigurdardottir, Margret Thorsteinsdóttir, Ingunn Olafsson, Isleifur Runolfsdottir, Hrafnhildur L. Helgason, Dadi Emilsdottir, Arna R. Agustsson, Arnar S. Bjornsson, Aron H. Kristjansdottir, Gudrun Thordardottir, Asdis Rosa Indridason, Olafur Skuli Jonsson, Asbjorn Gislason, Gauti Kjartan Olafsson, Andri Steingrimsdottir, Hlif Kampanis, Petros Hultcrantz, Malin Durie, Brian G. M. Harding, Stephen Landgren, Ola Palsson, Runolfur Love, Thorvarður Jon Kristinsson, Sigurdur Yngvi Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study |
topic_facet |
Oncology Hematology |
description |
Abstract Multiple myeloma (MM) patients have increased risk of severe coronavirus disease 2019 (COVID-19) when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Monoclonal gammopathy of undetermined significance (MGUS), the precursor of MM has been associated with immune dysfunction which may lead to severe COVID-19. No systematic data have been published on COVID-19 in individuals with MGUS. We conducted a large population-based cohort study evaluating the risk of SARS-CoV-2 infection and severe COVID-19 among individuals with MGUS. We included 75,422 Icelanders born before 1976, who had been screened for MGUS in the Iceland Screens Treats or Prevents Multiple Myeloma study (iStopMM). Data on SARS-CoV-2 testing and COVID-19 severity were acquired from the Icelandic COVID-19 Study Group. Using a test-negative study design, we included 32,047 iStopMM participants who had been tested for SARS-CoV-2, of whom 1754 had MGUS. Among these participants, 1100 participants, tested positive, 65 of whom had MGUS. Severe COVID-19 developed in 230 participants, including 16 with MGUS. MGUS was not associated with SARS-CoV-2 infection (Odds ratio (OR): 1.05; 95% confidence interval (CI): 0.81–1.36; p = 0.72) or severe COVID-19 (OR: 0.99; 95%CI: 0.52–1.91; p = 0.99). These findings indicate that MGUS does not affect the susceptibility to SARS-CoV-2 or the severity of COVID-19. |
format |
Article in Journal/Newspaper |
author |
Rognvaldsson, Saemundur Eythorsson, Elias Thorsteinsdottir, Sigrun Vidarsson, Brynjar Onundarson, Pall Torfi Agnarsson, Bjarni A. Sigurdardottir, Margret Thorsteinsdóttir, Ingunn Olafsson, Isleifur Runolfsdottir, Hrafnhildur L. Helgason, Dadi Emilsdottir, Arna R. Agustsson, Arnar S. Bjornsson, Aron H. Kristjansdottir, Gudrun Thordardottir, Asdis Rosa Indridason, Olafur Skuli Jonsson, Asbjorn Gislason, Gauti Kjartan Olafsson, Andri Steingrimsdottir, Hlif Kampanis, Petros Hultcrantz, Malin Durie, Brian G. M. Harding, Stephen Landgren, Ola Palsson, Runolfur Love, Thorvarður Jon Kristinsson, Sigurdur Yngvi |
author_facet |
Rognvaldsson, Saemundur Eythorsson, Elias Thorsteinsdottir, Sigrun Vidarsson, Brynjar Onundarson, Pall Torfi Agnarsson, Bjarni A. Sigurdardottir, Margret Thorsteinsdóttir, Ingunn Olafsson, Isleifur Runolfsdottir, Hrafnhildur L. Helgason, Dadi Emilsdottir, Arna R. Agustsson, Arnar S. Bjornsson, Aron H. Kristjansdottir, Gudrun Thordardottir, Asdis Rosa Indridason, Olafur Skuli Jonsson, Asbjorn Gislason, Gauti Kjartan Olafsson, Andri Steingrimsdottir, Hlif Kampanis, Petros Hultcrantz, Malin Durie, Brian G. M. Harding, Stephen Landgren, Ola Palsson, Runolfur Love, Thorvarður Jon Kristinsson, Sigurdur Yngvi |
author_sort |
Rognvaldsson, Saemundur |
title |
Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study |
title_short |
Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study |
title_full |
Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study |
title_fullStr |
Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study |
title_full_unstemmed |
Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study |
title_sort |
monoclonal gammopathy of undetermined significance and covid-19: a population-based cohort study |
publisher |
Springer Science and Business Media LLC |
publishDate |
2021 |
url |
http://dx.doi.org/10.1038/s41408-021-00580-7 https://www.nature.com/articles/s41408-021-00580-7.pdf https://www.nature.com/articles/s41408-021-00580-7 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Blood Cancer Journal volume 11, issue 12 ISSN 2044-5385 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41408-021-00580-7 |
container_title |
Blood Cancer Journal |
container_volume |
11 |
container_issue |
12 |
_version_ |
1766041178236518400 |