A possible effect of montelukast on neurological aging examined by the use of register data
Abstract Background The leukotriene receptor antagonist montelukast has been shown to rejuvenate aged brains in rats; however, data on humans are still scarce. Objective To investigate if montelukast may alleviate degenerative neurological changes using a register data. Setting Norwegian registry da...
Published in: | International Journal of Clinical Pharmacy |
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Springer Science and Business Media LLC
2020
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Online Access: | http://dx.doi.org/10.1007/s11096-020-01160-8 https://link.springer.com/content/pdf/10.1007/s11096-020-01160-8.pdf https://link.springer.com/article/10.1007/s11096-020-01160-8/fulltext.html |
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crspringernat:10.1007/s11096-020-01160-8 2023-05-15T18:34:39+02:00 A possible effect of montelukast on neurological aging examined by the use of register data Grinde, Bjørn Schirmer, Henrik Eggen, Anne Elise Aigner, Ludwig Engdahl, Bo Norwegian Institute of Public Health 2020 http://dx.doi.org/10.1007/s11096-020-01160-8 https://link.springer.com/content/pdf/10.1007/s11096-020-01160-8.pdf https://link.springer.com/article/10.1007/s11096-020-01160-8/fulltext.html en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY International Journal of Clinical Pharmacy volume 43, issue 3, page 541-548 ISSN 2210-7703 2210-7711 Pharmacology (medical) Pharmaceutical Science Pharmacology Toxicology Pharmacy journal-article 2020 crspringernat https://doi.org/10.1007/s11096-020-01160-8 2022-01-14T15:34:11Z Abstract Background The leukotriene receptor antagonist montelukast has been shown to rejuvenate aged brains in rats; however, data on humans are still scarce. Objective To investigate if montelukast may alleviate degenerative neurological changes using a register data. Setting Norwegian registry data analyses. Method The present observational study was based on data from the Norwegian Prescription Database and the Tromsø Study. The former has information regarding the use of prescription medicine; the latter includes tests for brain function such as subjective memory and finger-tapping. Multivariate linear regression analyses were performed to see how the use of various medications correlated with the test results, correcting for likely confounders. Main outcome measure Results on seven different tests considered relevant for neurological health were used as outcome. Results Previous use of montelukast correlated with improved scores on cognitive or neurological functioning (F = 2.20, p = 0.03 in a multivariate test). A range of other medications were tested with the same algorithm, including drugs acting on the immune system, but none of them correlated with (overall) significantly improved test results. Conclusion The present data suggest that montelukast may alleviate degenerative neurological changes associated with human aging. Article in Journal/Newspaper Tromsø Springer Nature (via Crossref) Tromsø International Journal of Clinical Pharmacy 43 3 541 548 |
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Springer Nature (via Crossref) |
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language |
English |
topic |
Pharmacology (medical) Pharmaceutical Science Pharmacology Toxicology Pharmacy |
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Pharmacology (medical) Pharmaceutical Science Pharmacology Toxicology Pharmacy Grinde, Bjørn Schirmer, Henrik Eggen, Anne Elise Aigner, Ludwig Engdahl, Bo A possible effect of montelukast on neurological aging examined by the use of register data |
topic_facet |
Pharmacology (medical) Pharmaceutical Science Pharmacology Toxicology Pharmacy |
description |
Abstract Background The leukotriene receptor antagonist montelukast has been shown to rejuvenate aged brains in rats; however, data on humans are still scarce. Objective To investigate if montelukast may alleviate degenerative neurological changes using a register data. Setting Norwegian registry data analyses. Method The present observational study was based on data from the Norwegian Prescription Database and the Tromsø Study. The former has information regarding the use of prescription medicine; the latter includes tests for brain function such as subjective memory and finger-tapping. Multivariate linear regression analyses were performed to see how the use of various medications correlated with the test results, correcting for likely confounders. Main outcome measure Results on seven different tests considered relevant for neurological health were used as outcome. Results Previous use of montelukast correlated with improved scores on cognitive or neurological functioning (F = 2.20, p = 0.03 in a multivariate test). A range of other medications were tested with the same algorithm, including drugs acting on the immune system, but none of them correlated with (overall) significantly improved test results. Conclusion The present data suggest that montelukast may alleviate degenerative neurological changes associated with human aging. |
author2 |
Norwegian Institute of Public Health |
format |
Article in Journal/Newspaper |
author |
Grinde, Bjørn Schirmer, Henrik Eggen, Anne Elise Aigner, Ludwig Engdahl, Bo |
author_facet |
Grinde, Bjørn Schirmer, Henrik Eggen, Anne Elise Aigner, Ludwig Engdahl, Bo |
author_sort |
Grinde, Bjørn |
title |
A possible effect of montelukast on neurological aging examined by the use of register data |
title_short |
A possible effect of montelukast on neurological aging examined by the use of register data |
title_full |
A possible effect of montelukast on neurological aging examined by the use of register data |
title_fullStr |
A possible effect of montelukast on neurological aging examined by the use of register data |
title_full_unstemmed |
A possible effect of montelukast on neurological aging examined by the use of register data |
title_sort |
possible effect of montelukast on neurological aging examined by the use of register data |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
http://dx.doi.org/10.1007/s11096-020-01160-8 https://link.springer.com/content/pdf/10.1007/s11096-020-01160-8.pdf https://link.springer.com/article/10.1007/s11096-020-01160-8/fulltext.html |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
International Journal of Clinical Pharmacy volume 43, issue 3, page 541-548 ISSN 2210-7703 2210-7711 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s11096-020-01160-8 |
container_title |
International Journal of Clinical Pharmacy |
container_volume |
43 |
container_issue |
3 |
container_start_page |
541 |
op_container_end_page |
548 |
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1766219503919693824 |