The regulatory role of GABAA receptor in Actinia equina nervous system and the possible effect of global ocean acidification
Abstract Global warming and connected acidification of the world ocean attract a substantial amount of research efforts, in particular in a context of their impact on behaviour and metabolism of marine organisms, such as Cnidaria. Nevertheless, mechanisms underlying Cnidarians’ neural signalling and...
Published in: | Pflügers Archiv - European Journal of Physiology |
---|---|
Main Authors: | , |
Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Springer Science and Business Media LLC
2021
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1007/s00424-021-02628-w https://link.springer.com/content/pdf/10.1007/s00424-021-02628-w.pdf https://link.springer.com/article/10.1007/s00424-021-02628-w/fulltext.html |
id |
crspringernat:10.1007/s00424-021-02628-w |
---|---|
record_format |
openpolar |
spelling |
crspringernat:10.1007/s00424-021-02628-w 2023-05-15T17:49:50+02:00 The regulatory role of GABAA receptor in Actinia equina nervous system and the possible effect of global ocean acidification Snigirov, Sergii Sylantyev, Sergiy Wellcome Trust EMBLAS 2021 http://dx.doi.org/10.1007/s00424-021-02628-w https://link.springer.com/content/pdf/10.1007/s00424-021-02628-w.pdf https://link.springer.com/article/10.1007/s00424-021-02628-w/fulltext.html en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Pflügers Archiv - European Journal of Physiology volume 473, issue 12, page 1851-1858 ISSN 0031-6768 1432-2013 Physiology (medical) Clinical Biochemistry Physiology journal-article 2021 crspringernat https://doi.org/10.1007/s00424-021-02628-w 2022-01-04T14:09:03Z Abstract Global warming and connected acidification of the world ocean attract a substantial amount of research efforts, in particular in a context of their impact on behaviour and metabolism of marine organisms, such as Cnidaria. Nevertheless, mechanisms underlying Cnidarians’ neural signalling and behaviour and their (possible) alterations due to the world ocean acidification remain poorly understood. Here we researched for the first time modulation of GABA A receptors (GABA A Rs) in Actinia equina (Cnidaria: Anthozoa) by pH fluctuations within a range predicted by the world ocean acidification scenarios for the next 80–100 years and by selective pharmacological activation. We found that in line with earlier studies on vertebrates, both changes of pH and activation of GABA A Rs with a selective allosteric agonist (diazepam) modulate electrical charge transfer through GABA A R and the whole-cell excitability. On top of that, diazepam modifies the animal behavioural reaction on startle response. However, despite behavioural reactions displayed by living animals are controlled by GABA A Rs, changes of pH do not alter them significantly. Possible mechanisms underlying the species resistance to acidification impact are discussed. Article in Journal/Newspaper Ocean acidification Springer Nature (via Crossref) Pflügers Archiv - European Journal of Physiology 473 12 1851 1858 |
institution |
Open Polar |
collection |
Springer Nature (via Crossref) |
op_collection_id |
crspringernat |
language |
English |
topic |
Physiology (medical) Clinical Biochemistry Physiology |
spellingShingle |
Physiology (medical) Clinical Biochemistry Physiology Snigirov, Sergii Sylantyev, Sergiy The regulatory role of GABAA receptor in Actinia equina nervous system and the possible effect of global ocean acidification |
topic_facet |
Physiology (medical) Clinical Biochemistry Physiology |
description |
Abstract Global warming and connected acidification of the world ocean attract a substantial amount of research efforts, in particular in a context of their impact on behaviour and metabolism of marine organisms, such as Cnidaria. Nevertheless, mechanisms underlying Cnidarians’ neural signalling and behaviour and their (possible) alterations due to the world ocean acidification remain poorly understood. Here we researched for the first time modulation of GABA A receptors (GABA A Rs) in Actinia equina (Cnidaria: Anthozoa) by pH fluctuations within a range predicted by the world ocean acidification scenarios for the next 80–100 years and by selective pharmacological activation. We found that in line with earlier studies on vertebrates, both changes of pH and activation of GABA A Rs with a selective allosteric agonist (diazepam) modulate electrical charge transfer through GABA A R and the whole-cell excitability. On top of that, diazepam modifies the animal behavioural reaction on startle response. However, despite behavioural reactions displayed by living animals are controlled by GABA A Rs, changes of pH do not alter them significantly. Possible mechanisms underlying the species resistance to acidification impact are discussed. |
author2 |
Wellcome Trust EMBLAS |
format |
Article in Journal/Newspaper |
author |
Snigirov, Sergii Sylantyev, Sergiy |
author_facet |
Snigirov, Sergii Sylantyev, Sergiy |
author_sort |
Snigirov, Sergii |
title |
The regulatory role of GABAA receptor in Actinia equina nervous system and the possible effect of global ocean acidification |
title_short |
The regulatory role of GABAA receptor in Actinia equina nervous system and the possible effect of global ocean acidification |
title_full |
The regulatory role of GABAA receptor in Actinia equina nervous system and the possible effect of global ocean acidification |
title_fullStr |
The regulatory role of GABAA receptor in Actinia equina nervous system and the possible effect of global ocean acidification |
title_full_unstemmed |
The regulatory role of GABAA receptor in Actinia equina nervous system and the possible effect of global ocean acidification |
title_sort |
regulatory role of gabaa receptor in actinia equina nervous system and the possible effect of global ocean acidification |
publisher |
Springer Science and Business Media LLC |
publishDate |
2021 |
url |
http://dx.doi.org/10.1007/s00424-021-02628-w https://link.springer.com/content/pdf/10.1007/s00424-021-02628-w.pdf https://link.springer.com/article/10.1007/s00424-021-02628-w/fulltext.html |
genre |
Ocean acidification |
genre_facet |
Ocean acidification |
op_source |
Pflügers Archiv - European Journal of Physiology volume 473, issue 12, page 1851-1858 ISSN 0031-6768 1432-2013 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s00424-021-02628-w |
container_title |
Pflügers Archiv - European Journal of Physiology |
container_volume |
473 |
container_issue |
12 |
container_start_page |
1851 |
op_container_end_page |
1858 |
_version_ |
1766156326532022272 |