An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes
Abstract No matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the...
Published in: | Applied Microbiology and Biotechnology |
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Springer Science and Business Media LLC
2021
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Online Access: | http://dx.doi.org/10.1007/s00253-021-11180-7 http://link.springer.com/content/pdf/10.1007/s00253-021-11180-7.pdf http://link.springer.com/article/10.1007/s00253-021-11180-7/fulltext.html |
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crspringernat:10.1007/s00253-021-11180-7 2023-05-15T15:56:09+02:00 An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes Schirmer, Cedric Maschke, Rüdiger W. Pörtner, Ralf Eibl, Dieter ZHAW Zürcher Hochschule für Angewandte Wissenschaften 2021 http://dx.doi.org/10.1007/s00253-021-11180-7 http://link.springer.com/content/pdf/10.1007/s00253-021-11180-7.pdf http://link.springer.com/article/10.1007/s00253-021-11180-7/fulltext.html en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Applied Microbiology and Biotechnology volume 105, issue 6, page 2225-2242 ISSN 0175-7598 1432-0614 Applied Microbiology and Biotechnology General Medicine Biotechnology journal-article 2021 crspringernat https://doi.org/10.1007/s00253-021-11180-7 2022-01-04T07:22:24Z Abstract No matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the characteristics and designs of bioreactors. Depending on the desired application, classic shaft-driven systems, bearing-mounted drives, or stirring elements that levitate freely in the vessel may be employed. In systems with drive shafts, process hygiene requirements also affect the type of seal used. For sensitive processes with high hygienic requirements, magnetic-driven stirring systems, which have been the focus of much research in recent years, are recommended. This review provides the reader with an overview of the most common agitation and seal types implemented in stirred bioreactor systems, highlights their advantages and disadvantages, and explains their possible fields of application. Special attention is paid to the development of magnetically driven agitators, which are widely used in reusable systems and are also becoming more and more important in their single-use counterparts. Key Points • Basic design of the most frequently used bioreactor type: the stirred tank bioreactor • Differences in most common seal types in stirred systems and fields of application • Comprehensive overview of commercially available bioreactor seal types • Increased use of magnetically driven agitation systems in single-use bioreactors Article in Journal/Newspaper common seal Springer Nature (via Crossref) Applied Microbiology and Biotechnology 105 6 2225 2242 |
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Springer Nature (via Crossref) |
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English |
topic |
Applied Microbiology and Biotechnology General Medicine Biotechnology |
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Applied Microbiology and Biotechnology General Medicine Biotechnology Schirmer, Cedric Maschke, Rüdiger W. Pörtner, Ralf Eibl, Dieter An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
topic_facet |
Applied Microbiology and Biotechnology General Medicine Biotechnology |
description |
Abstract No matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the characteristics and designs of bioreactors. Depending on the desired application, classic shaft-driven systems, bearing-mounted drives, or stirring elements that levitate freely in the vessel may be employed. In systems with drive shafts, process hygiene requirements also affect the type of seal used. For sensitive processes with high hygienic requirements, magnetic-driven stirring systems, which have been the focus of much research in recent years, are recommended. This review provides the reader with an overview of the most common agitation and seal types implemented in stirred bioreactor systems, highlights their advantages and disadvantages, and explains their possible fields of application. Special attention is paid to the development of magnetically driven agitators, which are widely used in reusable systems and are also becoming more and more important in their single-use counterparts. Key Points • Basic design of the most frequently used bioreactor type: the stirred tank bioreactor • Differences in most common seal types in stirred systems and fields of application • Comprehensive overview of commercially available bioreactor seal types • Increased use of magnetically driven agitation systems in single-use bioreactors |
author2 |
ZHAW Zürcher Hochschule für Angewandte Wissenschaften |
format |
Article in Journal/Newspaper |
author |
Schirmer, Cedric Maschke, Rüdiger W. Pörtner, Ralf Eibl, Dieter |
author_facet |
Schirmer, Cedric Maschke, Rüdiger W. Pörtner, Ralf Eibl, Dieter |
author_sort |
Schirmer, Cedric |
title |
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
title_short |
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
title_full |
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
title_fullStr |
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
title_full_unstemmed |
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
title_sort |
overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
publisher |
Springer Science and Business Media LLC |
publishDate |
2021 |
url |
http://dx.doi.org/10.1007/s00253-021-11180-7 http://link.springer.com/content/pdf/10.1007/s00253-021-11180-7.pdf http://link.springer.com/article/10.1007/s00253-021-11180-7/fulltext.html |
genre |
common seal |
genre_facet |
common seal |
op_source |
Applied Microbiology and Biotechnology volume 105, issue 6, page 2225-2242 ISSN 0175-7598 1432-0614 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s00253-021-11180-7 |
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Applied Microbiology and Biotechnology |
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105 |
container_issue |
6 |
container_start_page |
2225 |
op_container_end_page |
2242 |
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