Fate of MHCII in salmonids following 4WGD
Abstract Major histocompatibility complex (MHC) genes are key players in the adaptive immunity providing a defense against invading pathogens. Although the basic structures are similar when comparing mammalian and teleost MHC class II (MHCII) molecules, there are also clear-cut differences. Based on...
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crspringernat:10.1007/s00251-020-01190-6 2023-05-15T15:32:36+02:00 Fate of MHCII in salmonids following 4WGD Grimholt, Unni Lukacs, Morten Norges Forskningsråd 2020 http://dx.doi.org/10.1007/s00251-020-01190-6 http://link.springer.com/content/pdf/10.1007/s00251-020-01190-6.pdf http://link.springer.com/article/10.1007/s00251-020-01190-6/fulltext.html en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Immunogenetics volume 73, issue 1, page 79-91 ISSN 0093-7711 1432-1211 Genetics Immunology journal-article 2020 crspringernat https://doi.org/10.1007/s00251-020-01190-6 2022-01-04T15:26:26Z Abstract Major histocompatibility complex (MHC) genes are key players in the adaptive immunity providing a defense against invading pathogens. Although the basic structures are similar when comparing mammalian and teleost MHC class II (MHCII) molecules, there are also clear-cut differences. Based on structural requirements, the teleosts non-classical MHCII molecules do not comply with a function similar to the human HLA-DM and HLA-DO, i.e., assisting in peptide loading and editing of classical MHCII molecules. We have previously studied the evolution of teleost class II genes identifying various lineages and tracing their phylogenetic occurrence back to ancient ray-finned fishes. We found no syntenic MHCII regions shared between cyprinids, salmonids, and neoteleosts, suggesting regional instabilities. Salmonids have experienced a unique whole genome duplication 94 million years ago, providing them with the opportunity to experiment with gene duplicates. Many salmonid genomes have recently become available, and here we set out to investigate how MHCII has evolved in salmonids using Northern pike as a diploid sister phyla, that split from the salmonid lineage prior to the fourth whole genome duplication (4WGD) event. We identified 120 MHCII genes in pike and salmonids, ranging from 11 to 20 genes per species analyzed where DB-group genes had the most expansions. Comparing the MHC of Northern pike with that of Atlantic salmon and other salmonids species provides a tale of gene loss, translocations, and genome rearrangements. Article in Journal/Newspaper Atlantic salmon Springer Nature (via Crossref) Immunogenetics 73 1 79 91 |
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English |
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Genetics Immunology |
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Genetics Immunology Grimholt, Unni Lukacs, Morten Fate of MHCII in salmonids following 4WGD |
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Genetics Immunology |
description |
Abstract Major histocompatibility complex (MHC) genes are key players in the adaptive immunity providing a defense against invading pathogens. Although the basic structures are similar when comparing mammalian and teleost MHC class II (MHCII) molecules, there are also clear-cut differences. Based on structural requirements, the teleosts non-classical MHCII molecules do not comply with a function similar to the human HLA-DM and HLA-DO, i.e., assisting in peptide loading and editing of classical MHCII molecules. We have previously studied the evolution of teleost class II genes identifying various lineages and tracing their phylogenetic occurrence back to ancient ray-finned fishes. We found no syntenic MHCII regions shared between cyprinids, salmonids, and neoteleosts, suggesting regional instabilities. Salmonids have experienced a unique whole genome duplication 94 million years ago, providing them with the opportunity to experiment with gene duplicates. Many salmonid genomes have recently become available, and here we set out to investigate how MHCII has evolved in salmonids using Northern pike as a diploid sister phyla, that split from the salmonid lineage prior to the fourth whole genome duplication (4WGD) event. We identified 120 MHCII genes in pike and salmonids, ranging from 11 to 20 genes per species analyzed where DB-group genes had the most expansions. Comparing the MHC of Northern pike with that of Atlantic salmon and other salmonids species provides a tale of gene loss, translocations, and genome rearrangements. |
author2 |
Norges Forskningsråd |
format |
Article in Journal/Newspaper |
author |
Grimholt, Unni Lukacs, Morten |
author_facet |
Grimholt, Unni Lukacs, Morten |
author_sort |
Grimholt, Unni |
title |
Fate of MHCII in salmonids following 4WGD |
title_short |
Fate of MHCII in salmonids following 4WGD |
title_full |
Fate of MHCII in salmonids following 4WGD |
title_fullStr |
Fate of MHCII in salmonids following 4WGD |
title_full_unstemmed |
Fate of MHCII in salmonids following 4WGD |
title_sort |
fate of mhcii in salmonids following 4wgd |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
http://dx.doi.org/10.1007/s00251-020-01190-6 http://link.springer.com/content/pdf/10.1007/s00251-020-01190-6.pdf http://link.springer.com/article/10.1007/s00251-020-01190-6/fulltext.html |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Immunogenetics volume 73, issue 1, page 79-91 ISSN 0093-7711 1432-1211 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s00251-020-01190-6 |
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Immunogenetics |
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73 |
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1 |
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79 |
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91 |
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1766363091007700992 |