Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample
Abstract Background and purpose In the group of severe mental disorders, psychotic depression (PD) is essentially under-researched. Knowledge about the risk factors is scarce and this applies especially to early risk factors. Our aim was to study early childhood and adolescent risk factors of PD in...
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Online Access: | http://dx.doi.org/10.1007/s00127-020-01835-7 http://link.springer.com/content/pdf/10.1007/s00127-020-01835-7.pdf http://link.springer.com/article/10.1007/s00127-020-01835-7/fulltext.html |
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crspringernat:10.1007/s00127-020-01835-7 2023-05-15T17:42:48+02:00 Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample Nietola, Miika Huovinen, Hanna Heiskala, Anni Nordström, Tanja Miettunen, Jouko Korkeila, Jyrki Jääskeläinen, Erika Turku University Foundation 2020 http://dx.doi.org/10.1007/s00127-020-01835-7 http://link.springer.com/content/pdf/10.1007/s00127-020-01835-7.pdf http://link.springer.com/article/10.1007/s00127-020-01835-7/fulltext.html en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Social Psychiatry and Psychiatric Epidemiology volume 55, issue 9, page 1179-1186 ISSN 0933-7954 1433-9285 Psychiatry and Mental health Social Psychology Health (social science) Epidemiology journal-article 2020 crspringernat https://doi.org/10.1007/s00127-020-01835-7 2022-01-04T10:53:38Z Abstract Background and purpose In the group of severe mental disorders, psychotic depression (PD) is essentially under-researched. Knowledge about the risk factors is scarce and this applies especially to early risk factors. Our aim was to study early childhood and adolescent risk factors of PD in a representative birth cohort sample with a follow-up of up to 50 years. Methods The study was carried out using the Northern Finland Birth Cohort 1966 (NFBC 1966). We used non-psychotic depression (NPD) ( n = 746), schizophrenia (SZ) ( n = 195), psychotic bipolar disorder (PBD) ( n = 27), other psychoses (PNOS) ( n = 136) and healthy controls (HC) ( n = 8200) as comparison groups for PD ( n = 58). We analysed several potential early risk factors from time of birth until the age of 16 years. Results The main finding was that parents’ psychiatric illness [HR 3.59 (1.84–7.04)] was a risk factor and a high sports grade in school was a protective factor [HR 0.29 (0.11–0.73)] for PD also after adjusting for covariates in the multivariate Cox regression model. Parental psychotic illness was an especially strong risk factor for PD. The PD subjects had a parent with psychiatric illness significantly more often ( p < 0.05) than NPD subjects. Differences between PD and other disorder groups were otherwise small. Conclusions A low sports grade in school may be a risk factor for PD. Psychiatric illnesses, especially psychoses, are common in the parents of PD subjects. A surprisingly low number of statistically significant risk factors may have resulted from the size of the PD sample and the underlying heterogeneity of the etiology of PD. Article in Journal/Newspaper Northern Finland Springer Nature (via Crossref) Social Psychiatry and Psychiatric Epidemiology 55 9 1179 1186 |
institution |
Open Polar |
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Springer Nature (via Crossref) |
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crspringernat |
language |
English |
topic |
Psychiatry and Mental health Social Psychology Health (social science) Epidemiology |
spellingShingle |
Psychiatry and Mental health Social Psychology Health (social science) Epidemiology Nietola, Miika Huovinen, Hanna Heiskala, Anni Nordström, Tanja Miettunen, Jouko Korkeila, Jyrki Jääskeläinen, Erika Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
topic_facet |
Psychiatry and Mental health Social Psychology Health (social science) Epidemiology |
description |
Abstract Background and purpose In the group of severe mental disorders, psychotic depression (PD) is essentially under-researched. Knowledge about the risk factors is scarce and this applies especially to early risk factors. Our aim was to study early childhood and adolescent risk factors of PD in a representative birth cohort sample with a follow-up of up to 50 years. Methods The study was carried out using the Northern Finland Birth Cohort 1966 (NFBC 1966). We used non-psychotic depression (NPD) ( n = 746), schizophrenia (SZ) ( n = 195), psychotic bipolar disorder (PBD) ( n = 27), other psychoses (PNOS) ( n = 136) and healthy controls (HC) ( n = 8200) as comparison groups for PD ( n = 58). We analysed several potential early risk factors from time of birth until the age of 16 years. Results The main finding was that parents’ psychiatric illness [HR 3.59 (1.84–7.04)] was a risk factor and a high sports grade in school was a protective factor [HR 0.29 (0.11–0.73)] for PD also after adjusting for covariates in the multivariate Cox regression model. Parental psychotic illness was an especially strong risk factor for PD. The PD subjects had a parent with psychiatric illness significantly more often ( p < 0.05) than NPD subjects. Differences between PD and other disorder groups were otherwise small. Conclusions A low sports grade in school may be a risk factor for PD. Psychiatric illnesses, especially psychoses, are common in the parents of PD subjects. A surprisingly low number of statistically significant risk factors may have resulted from the size of the PD sample and the underlying heterogeneity of the etiology of PD. |
author2 |
Turku University Foundation |
format |
Article in Journal/Newspaper |
author |
Nietola, Miika Huovinen, Hanna Heiskala, Anni Nordström, Tanja Miettunen, Jouko Korkeila, Jyrki Jääskeläinen, Erika |
author_facet |
Nietola, Miika Huovinen, Hanna Heiskala, Anni Nordström, Tanja Miettunen, Jouko Korkeila, Jyrki Jääskeläinen, Erika |
author_sort |
Nietola, Miika |
title |
Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
title_short |
Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
title_full |
Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
title_fullStr |
Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
title_full_unstemmed |
Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
title_sort |
early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
http://dx.doi.org/10.1007/s00127-020-01835-7 http://link.springer.com/content/pdf/10.1007/s00127-020-01835-7.pdf http://link.springer.com/article/10.1007/s00127-020-01835-7/fulltext.html |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Social Psychiatry and Psychiatric Epidemiology volume 55, issue 9, page 1179-1186 ISSN 0933-7954 1433-9285 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s00127-020-01835-7 |
container_title |
Social Psychiatry and Psychiatric Epidemiology |
container_volume |
55 |
container_issue |
9 |
container_start_page |
1179 |
op_container_end_page |
1186 |
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1766144726372712448 |