The Association between Urinary Sodium-Potassium Ratio, Kidney Function, and Blood Pressure in a Cohort from the General Population
Introduction: Subclinical kidney dysfunction may contribute to salt-sensitive hypertension. We assessed the association between the urinary sodium-potassium ratio (Na/K ratio) and blood pressure (BP) in a general population cohort without diabetes, chronic kidney disease, cardiovascular disease, or...
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crskarger:10.1159/000535977 2024-06-09T07:48:34+00:00 The Association between Urinary Sodium-Potassium Ratio, Kidney Function, and Blood Pressure in a Cohort from the General Population Brobak, Karl Marius Melsom, Toralf Eriksen, Bjørn Odvar Høieggen, Aud Norvik, Jon Viljar Solbu, Marit Dahl 2024 http://dx.doi.org/10.1159/000535977 https://karger.com/kbr/article-pdf/49/1/184/4181000/000535977.pdf en eng S. Karger AG https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/ Kidney and Blood Pressure Research volume 49, issue 1, page 184-195 ISSN 1420-4096 1423-0143 journal-article 2024 crskarger https://doi.org/10.1159/000535977 2024-05-15T13:29:41Z Introduction: Subclinical kidney dysfunction may contribute to salt-sensitive hypertension. We assessed the association between the urinary sodium-potassium ratio (Na/K ratio) and blood pressure (BP) in a general population cohort without diabetes, chronic kidney disease, cardiovascular disease, or treated hypertension. We investigated whether any such association was mediated by the kidney function markers measured glomerular filtration rate (mGFR), urinary albumin-creatinine ratio (ACR), and urinary epidermal growth factor-creatinine ratio (EGF-Cr). Methods: The Tromsø Study is a population-based study of inhabitants of the municipality of Tromsø, Northern Norway. Participants aged 50–62 years, without diabetes, chronic kidney disease, or cardiovascular disease, were invited to the substudy Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6; 2007–09). For the present study, we excluded participants reporting the use of 1 or more antihypertensive agents, leaving 1,311 RENIS-T6 participants for a cross-sectional analysis. We measured office BP, 24-h ambulatory blood pressure (ABP), and mGFR using iohexol clearance. Na/K ratio, ACR, and EGF-Cr were measured in morning urine samples. Results: Urinary Na/K ratio was significantly associated with systolic office BP and ABP independently of cardiovascular risk factors and kidney function markers. A one-standard deviation unit increase in the Na/K ratio was associated with increased systolic ABP by 1.0 (0.3–1.6) mm Hg. Urinary Na/K ratio showed a stronger association with office BP than ABP. EGF-Cr, ACR, and mGFR did not mediate the relationship between urinary Na/K ratio and systolic BP. Conclusions: In a representative sample of the middle-aged North-European population without diabetes, chronic kidney disease, cardiovascular disease, or treated hypertension, there was a consistent association between urinary Na/K ratio and BP. The association with BP was not mediated through kidney function measures, suggesting a relationship between a diet with high sodium and ... Article in Journal/Newspaper Northern Norway Tromsø Karger Norway Tromsø Kidney and Blood Pressure Research 49 1 184 195 |
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Open Polar |
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English |
description |
Introduction: Subclinical kidney dysfunction may contribute to salt-sensitive hypertension. We assessed the association between the urinary sodium-potassium ratio (Na/K ratio) and blood pressure (BP) in a general population cohort without diabetes, chronic kidney disease, cardiovascular disease, or treated hypertension. We investigated whether any such association was mediated by the kidney function markers measured glomerular filtration rate (mGFR), urinary albumin-creatinine ratio (ACR), and urinary epidermal growth factor-creatinine ratio (EGF-Cr). Methods: The Tromsø Study is a population-based study of inhabitants of the municipality of Tromsø, Northern Norway. Participants aged 50–62 years, without diabetes, chronic kidney disease, or cardiovascular disease, were invited to the substudy Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6; 2007–09). For the present study, we excluded participants reporting the use of 1 or more antihypertensive agents, leaving 1,311 RENIS-T6 participants for a cross-sectional analysis. We measured office BP, 24-h ambulatory blood pressure (ABP), and mGFR using iohexol clearance. Na/K ratio, ACR, and EGF-Cr were measured in morning urine samples. Results: Urinary Na/K ratio was significantly associated with systolic office BP and ABP independently of cardiovascular risk factors and kidney function markers. A one-standard deviation unit increase in the Na/K ratio was associated with increased systolic ABP by 1.0 (0.3–1.6) mm Hg. Urinary Na/K ratio showed a stronger association with office BP than ABP. EGF-Cr, ACR, and mGFR did not mediate the relationship between urinary Na/K ratio and systolic BP. Conclusions: In a representative sample of the middle-aged North-European population without diabetes, chronic kidney disease, cardiovascular disease, or treated hypertension, there was a consistent association between urinary Na/K ratio and BP. The association with BP was not mediated through kidney function measures, suggesting a relationship between a diet with high sodium and ... |
format |
Article in Journal/Newspaper |
author |
Brobak, Karl Marius Melsom, Toralf Eriksen, Bjørn Odvar Høieggen, Aud Norvik, Jon Viljar Solbu, Marit Dahl |
spellingShingle |
Brobak, Karl Marius Melsom, Toralf Eriksen, Bjørn Odvar Høieggen, Aud Norvik, Jon Viljar Solbu, Marit Dahl The Association between Urinary Sodium-Potassium Ratio, Kidney Function, and Blood Pressure in a Cohort from the General Population |
author_facet |
Brobak, Karl Marius Melsom, Toralf Eriksen, Bjørn Odvar Høieggen, Aud Norvik, Jon Viljar Solbu, Marit Dahl |
author_sort |
Brobak, Karl Marius |
title |
The Association between Urinary Sodium-Potassium Ratio, Kidney Function, and Blood Pressure in a Cohort from the General Population |
title_short |
The Association between Urinary Sodium-Potassium Ratio, Kidney Function, and Blood Pressure in a Cohort from the General Population |
title_full |
The Association between Urinary Sodium-Potassium Ratio, Kidney Function, and Blood Pressure in a Cohort from the General Population |
title_fullStr |
The Association between Urinary Sodium-Potassium Ratio, Kidney Function, and Blood Pressure in a Cohort from the General Population |
title_full_unstemmed |
The Association between Urinary Sodium-Potassium Ratio, Kidney Function, and Blood Pressure in a Cohort from the General Population |
title_sort |
association between urinary sodium-potassium ratio, kidney function, and blood pressure in a cohort from the general population |
publisher |
S. Karger AG |
publishDate |
2024 |
url |
http://dx.doi.org/10.1159/000535977 https://karger.com/kbr/article-pdf/49/1/184/4181000/000535977.pdf |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Northern Norway Tromsø |
genre_facet |
Northern Norway Tromsø |
op_source |
Kidney and Blood Pressure Research volume 49, issue 1, page 184-195 ISSN 1420-4096 1423-0143 |
op_rights |
https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/ |
op_doi |
https://doi.org/10.1159/000535977 |
container_title |
Kidney and Blood Pressure Research |
container_volume |
49 |
container_issue |
1 |
container_start_page |
184 |
op_container_end_page |
195 |
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1801380337680384000 |