Amyotrophic Lateral Sclerosis in Southwestern and Eastern Finland
Introduction: The incidence of amyotrophic lateral sclerosis (ALS) worldwide is approximately 1–2.6/1,000,000 and prevalence is 5–6/100,000. ALS has been suggested to be relatively common in Finland, but epidemiological information on the subject is scarce and outdated. Material and Methods: Patient...
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crskarger:10.1159/000531238 2024-06-23T07:54:19+00:00 Amyotrophic Lateral Sclerosis in Southwestern and Eastern Finland Hanhisuanto, Mirka Solje, Eino Jokela, Manu Sipilä, Jussi O.T. 2023 http://dx.doi.org/10.1159/000531238 https://karger.com/ned/article-pdf/57/4/238/4016941/000531238.pdf en eng S. Karger AG https://karger.com/pages/terms-and-conditions https://karger.com/pages/terms-and-conditions Neuroepidemiology volume 57, issue 4, page 238-245 ISSN 0251-5350 1423-0208 journal-article 2023 crskarger https://doi.org/10.1159/000531238 2024-06-12T04:07:28Z Introduction: The incidence of amyotrophic lateral sclerosis (ALS) worldwide is approximately 1–2.6/1,000,000 and prevalence is 5–6/100,000. ALS has been suggested to be relatively common in Finland, but epidemiological information on the subject is scarce and outdated. Material and Methods: Patients with ALS diagnostic codes were identified from mandatory administrative registries in the provinces of Southwestern Finland (population circa 430,000) and North Karelia (population circa 170,000), together comprising 11.7% of the total population of Finland. The diagnoses were verified, and data were extracted by reviewing the patient records. Incidence period was 2010–2018, and the prevalence date was December 31, 2018. Age-standardization was performed using the European Standard Population 2013 (ESP2013). Results: Overall crude incidence of ALS was 4.2/100,000 person-years in Southwestern Finland (ESP2013: 4.0/100,000) and 5.6/100,000 person-years in North Karelia (ESP2013: 4.8/100,000), while crude prevalences were 11.9/100,000 (ESP2013: 10.5/100,000) and 10.9/100,000 (ESP2013: 9.3/100,000), respectively. Mean age at diagnosis was 65.5–71.6 years in women (higher in Southwestern Finland compared to North Karelia, p = 0.003) and 64.7–67.3 years in men (no difference between provinces, p = 0.39). The diagnosis had been made in 50% before the age of 70 years in Southwestern Finland and before the age of 65 years in 51% in North Karelia. Genetic testing had been conducted in 28% of all patients with the most common findings being SOD1 and C9orf72. After the diagnosis, mean survival was 2.0–2.7 and median survival 1.3–1.4 years. Onset phenotype (p < 0.001), age at diagnosis (p < 0.001), and genotype (p = 0.001) predicted survival. Riluzole had been used by 25% of patients and tracheostomy and invasive ventilation (TIV) had been performed in <1%. Conclusions: Both incidence and prevalence of ALS in Finland are among the highest in the world but with some notable differences between the eastern and ... Article in Journal/Newspaper karelia* Karger Neuroepidemiology |
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Introduction: The incidence of amyotrophic lateral sclerosis (ALS) worldwide is approximately 1–2.6/1,000,000 and prevalence is 5–6/100,000. ALS has been suggested to be relatively common in Finland, but epidemiological information on the subject is scarce and outdated. Material and Methods: Patients with ALS diagnostic codes were identified from mandatory administrative registries in the provinces of Southwestern Finland (population circa 430,000) and North Karelia (population circa 170,000), together comprising 11.7% of the total population of Finland. The diagnoses were verified, and data were extracted by reviewing the patient records. Incidence period was 2010–2018, and the prevalence date was December 31, 2018. Age-standardization was performed using the European Standard Population 2013 (ESP2013). Results: Overall crude incidence of ALS was 4.2/100,000 person-years in Southwestern Finland (ESP2013: 4.0/100,000) and 5.6/100,000 person-years in North Karelia (ESP2013: 4.8/100,000), while crude prevalences were 11.9/100,000 (ESP2013: 10.5/100,000) and 10.9/100,000 (ESP2013: 9.3/100,000), respectively. Mean age at diagnosis was 65.5–71.6 years in women (higher in Southwestern Finland compared to North Karelia, p = 0.003) and 64.7–67.3 years in men (no difference between provinces, p = 0.39). The diagnosis had been made in 50% before the age of 70 years in Southwestern Finland and before the age of 65 years in 51% in North Karelia. Genetic testing had been conducted in 28% of all patients with the most common findings being SOD1 and C9orf72. After the diagnosis, mean survival was 2.0–2.7 and median survival 1.3–1.4 years. Onset phenotype (p < 0.001), age at diagnosis (p < 0.001), and genotype (p = 0.001) predicted survival. Riluzole had been used by 25% of patients and tracheostomy and invasive ventilation (TIV) had been performed in <1%. Conclusions: Both incidence and prevalence of ALS in Finland are among the highest in the world but with some notable differences between the eastern and ... |
format |
Article in Journal/Newspaper |
author |
Hanhisuanto, Mirka Solje, Eino Jokela, Manu Sipilä, Jussi O.T. |
spellingShingle |
Hanhisuanto, Mirka Solje, Eino Jokela, Manu Sipilä, Jussi O.T. Amyotrophic Lateral Sclerosis in Southwestern and Eastern Finland |
author_facet |
Hanhisuanto, Mirka Solje, Eino Jokela, Manu Sipilä, Jussi O.T. |
author_sort |
Hanhisuanto, Mirka |
title |
Amyotrophic Lateral Sclerosis in Southwestern and Eastern Finland |
title_short |
Amyotrophic Lateral Sclerosis in Southwestern and Eastern Finland |
title_full |
Amyotrophic Lateral Sclerosis in Southwestern and Eastern Finland |
title_fullStr |
Amyotrophic Lateral Sclerosis in Southwestern and Eastern Finland |
title_full_unstemmed |
Amyotrophic Lateral Sclerosis in Southwestern and Eastern Finland |
title_sort |
amyotrophic lateral sclerosis in southwestern and eastern finland |
publisher |
S. Karger AG |
publishDate |
2023 |
url |
http://dx.doi.org/10.1159/000531238 https://karger.com/ned/article-pdf/57/4/238/4016941/000531238.pdf |
genre |
karelia* |
genre_facet |
karelia* |
op_source |
Neuroepidemiology volume 57, issue 4, page 238-245 ISSN 0251-5350 1423-0208 |
op_rights |
https://karger.com/pages/terms-and-conditions https://karger.com/pages/terms-and-conditions |
op_doi |
https://doi.org/10.1159/000531238 |
container_title |
Neuroepidemiology |
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1802646431544115200 |