High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study
Background: There are fewer than 5 population-based studies of dystonia worldwide. Only one utilized a movement disorders neurologist. Given the potential for founder effects, and the highly genetic nature of dystonia, the Faroe Islands provide a particularly interesting setting to study the prevale...
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crskarger:10.1159/000502455 2024-06-09T07:45:51+00:00 High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study Louis, Elan D. Eliasen, Eina H. Kim, Christine Y. Ferrer, Monica Gaini, Shahin Petersen, Maria Skaalum 2019 http://dx.doi.org/10.1159/000502455 https://www.karger.com/Article/Pdf/502455 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses Neuroepidemiology volume 53, issue 3-4, page 220-224 ISSN 0251-5350 1423-0208 journal-article 2019 crskarger https://doi.org/10.1159/000502455 2024-05-15T13:29:16Z Background: There are fewer than 5 population-based studies of dystonia worldwide. Only one utilized a movement disorders neurologist. Given the potential for founder effects, and the highly genetic nature of dystonia, the Faroe Islands provide a particularly interesting setting to study the prevalence of dystonia. Objective: To estimate the prevalence of dystonia. Methods: We used a 2-phase, population-based design, screening 1,334 randomly selected Faroese individuals aged ≥40 years from which a subsample of 227 participated in an in-person clinical evaluation. Dystonia was assessed by 2 movement disorder neurologists using videotaped examinations. Results: Two of 227 (0.88%, 95% CI –0.33 to 2.09%) were diagnosed with cervical or segmental dystonia. An unusual form of thumb flexion dystonia was noted in 75 more, yielding a combined prevalence of 33.92% (95% CI 27.73–40.11%). Conclusions: The prevalence of cervical or segmental dystonia was as high as in one prior population-based study using similar methods. Furthermore, an unusual form of thumb flexion dystonia was uncovered, which yielded an extraordinarily high prevalence of dystonia in this population. Although our methods likely contributed to more complete capture of subtle dystonia, founder effects are highly likely to have been an additional major contributor to these findings. Article in Journal/Newspaper Faroe Islands Karger Faroe Islands Thumb ENVELOPE(-64.259,-64.259,-65.247,-65.247) Neuroepidemiology 53 3-4 220 224 |
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Background: There are fewer than 5 population-based studies of dystonia worldwide. Only one utilized a movement disorders neurologist. Given the potential for founder effects, and the highly genetic nature of dystonia, the Faroe Islands provide a particularly interesting setting to study the prevalence of dystonia. Objective: To estimate the prevalence of dystonia. Methods: We used a 2-phase, population-based design, screening 1,334 randomly selected Faroese individuals aged ≥40 years from which a subsample of 227 participated in an in-person clinical evaluation. Dystonia was assessed by 2 movement disorder neurologists using videotaped examinations. Results: Two of 227 (0.88%, 95% CI –0.33 to 2.09%) were diagnosed with cervical or segmental dystonia. An unusual form of thumb flexion dystonia was noted in 75 more, yielding a combined prevalence of 33.92% (95% CI 27.73–40.11%). Conclusions: The prevalence of cervical or segmental dystonia was as high as in one prior population-based study using similar methods. Furthermore, an unusual form of thumb flexion dystonia was uncovered, which yielded an extraordinarily high prevalence of dystonia in this population. Although our methods likely contributed to more complete capture of subtle dystonia, founder effects are highly likely to have been an additional major contributor to these findings. |
format |
Article in Journal/Newspaper |
author |
Louis, Elan D. Eliasen, Eina H. Kim, Christine Y. Ferrer, Monica Gaini, Shahin Petersen, Maria Skaalum |
spellingShingle |
Louis, Elan D. Eliasen, Eina H. Kim, Christine Y. Ferrer, Monica Gaini, Shahin Petersen, Maria Skaalum High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study |
author_facet |
Louis, Elan D. Eliasen, Eina H. Kim, Christine Y. Ferrer, Monica Gaini, Shahin Petersen, Maria Skaalum |
author_sort |
Louis, Elan D. |
title |
High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study |
title_short |
High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study |
title_full |
High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study |
title_fullStr |
High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study |
title_full_unstemmed |
High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study |
title_sort |
high prevalence of dystonia in the faroe islands: a population-based study |
publisher |
S. Karger AG |
publishDate |
2019 |
url |
http://dx.doi.org/10.1159/000502455 https://www.karger.com/Article/Pdf/502455 |
long_lat |
ENVELOPE(-64.259,-64.259,-65.247,-65.247) |
geographic |
Faroe Islands Thumb |
geographic_facet |
Faroe Islands Thumb |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Neuroepidemiology volume 53, issue 3-4, page 220-224 ISSN 0251-5350 1423-0208 |
op_rights |
https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses |
op_doi |
https://doi.org/10.1159/000502455 |
container_title |
Neuroepidemiology |
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53 |
container_issue |
3-4 |
container_start_page |
220 |
op_container_end_page |
224 |
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1801375480230707200 |