Very Early Neurophysiological Study in Guillain-Barre Syndrome
Purpose: The diagnosis of Guillain-Barre syndrome (GBS) in the very early stage may be challenging. Our aim was to report the neurophysiological abnormalities in GBS within 4 days of clinical onset. We expected that GBS will be diagnosed by the assistance of neurophysiological study in the very earl...
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crskarger:10.1159/000494261 2024-06-09T07:45:36+00:00 Very Early Neurophysiological Study in Guillain-Barre Syndrome Jin, Jiaoting Hu, Fangfang Qin, Xing Liu, Xuan Li, Min Dang, Yonghui Dang, Jingxia 2018 http://dx.doi.org/10.1159/000494261 https://www.karger.com/Article/Pdf/494261 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses European Neurology volume 80, issue 1-2, page 100-105 ISSN 0014-3022 1421-9913 journal-article 2018 crskarger https://doi.org/10.1159/000494261 2024-05-15T13:29:32Z Purpose: The diagnosis of Guillain-Barre syndrome (GBS) in the very early stage may be challenging. Our aim was to report the neurophysiological abnormalities in GBS within 4 days of clinical onset. We expected that GBS will be diagnosed by the assistance of neurophysiological study in the very early stage. Methods: We prospectively recruited patients with a diagnosis of GBS discharged from First Affiliated Hospital of Xi’an Jiaotong University and Xi Jing Hospital. Patients were classified into 3 groups according to the onset of symptoms to electromyography examination interval (OEI). The neurophysiological findings were carried out using standard procedures. All patients were examined by the same experienced neurophysiologist. Results: There were not significant group differences in abnormal rate, distal motor latency (DML), motor nerve conduction velocity (MNCV), F response (FR), compound muscle action potential (CMAP), conduction block (CB), sensory nerve action potential (SNAP), and sensory nerve conduction velocity among OEI ≤4 days, 4< OEI ≤10 days, and OEI > 10 days groups. Motor nerves were more affected than sensory nerves in neurophysiological presentation in very early stage patients. The difference of motor nerves and sensory nerves was statistically significant in lower limbs, but was not in upper limbs. In motor nerve conduction studies, the abnormal rate of DML, MNCV, FR, CB was more common seen in ulnar and peroneal nerve than median and tibial nerve, the abnormal rate of CMAP was the same in ulnar, median, peroneal and tibial nerve. In sensory nerve conduction studies, the abnormal rate of ulnar nerve and median nerve was higher than the superficial peroneal nerve and sural nerve. The OEI was not correlated with the SNAP decrease rate of median (r = 0.10, p = 0.23) and ulnar (r = 0.26, p = 0.06) but was statistically correlated with sural SNAP decrease rate (r = 0.29, p = 0.04). The sural-sparing pattern phenomenon was the most commonly discovered phenomenon in very early ... Article in Journal/Newspaper DML Karger European Neurology 80 1-2 100 105 |
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English |
description |
Purpose: The diagnosis of Guillain-Barre syndrome (GBS) in the very early stage may be challenging. Our aim was to report the neurophysiological abnormalities in GBS within 4 days of clinical onset. We expected that GBS will be diagnosed by the assistance of neurophysiological study in the very early stage. Methods: We prospectively recruited patients with a diagnosis of GBS discharged from First Affiliated Hospital of Xi’an Jiaotong University and Xi Jing Hospital. Patients were classified into 3 groups according to the onset of symptoms to electromyography examination interval (OEI). The neurophysiological findings were carried out using standard procedures. All patients were examined by the same experienced neurophysiologist. Results: There were not significant group differences in abnormal rate, distal motor latency (DML), motor nerve conduction velocity (MNCV), F response (FR), compound muscle action potential (CMAP), conduction block (CB), sensory nerve action potential (SNAP), and sensory nerve conduction velocity among OEI ≤4 days, 4< OEI ≤10 days, and OEI > 10 days groups. Motor nerves were more affected than sensory nerves in neurophysiological presentation in very early stage patients. The difference of motor nerves and sensory nerves was statistically significant in lower limbs, but was not in upper limbs. In motor nerve conduction studies, the abnormal rate of DML, MNCV, FR, CB was more common seen in ulnar and peroneal nerve than median and tibial nerve, the abnormal rate of CMAP was the same in ulnar, median, peroneal and tibial nerve. In sensory nerve conduction studies, the abnormal rate of ulnar nerve and median nerve was higher than the superficial peroneal nerve and sural nerve. The OEI was not correlated with the SNAP decrease rate of median (r = 0.10, p = 0.23) and ulnar (r = 0.26, p = 0.06) but was statistically correlated with sural SNAP decrease rate (r = 0.29, p = 0.04). The sural-sparing pattern phenomenon was the most commonly discovered phenomenon in very early ... |
format |
Article in Journal/Newspaper |
author |
Jin, Jiaoting Hu, Fangfang Qin, Xing Liu, Xuan Li, Min Dang, Yonghui Dang, Jingxia |
spellingShingle |
Jin, Jiaoting Hu, Fangfang Qin, Xing Liu, Xuan Li, Min Dang, Yonghui Dang, Jingxia Very Early Neurophysiological Study in Guillain-Barre Syndrome |
author_facet |
Jin, Jiaoting Hu, Fangfang Qin, Xing Liu, Xuan Li, Min Dang, Yonghui Dang, Jingxia |
author_sort |
Jin, Jiaoting |
title |
Very Early Neurophysiological Study in Guillain-Barre Syndrome |
title_short |
Very Early Neurophysiological Study in Guillain-Barre Syndrome |
title_full |
Very Early Neurophysiological Study in Guillain-Barre Syndrome |
title_fullStr |
Very Early Neurophysiological Study in Guillain-Barre Syndrome |
title_full_unstemmed |
Very Early Neurophysiological Study in Guillain-Barre Syndrome |
title_sort |
very early neurophysiological study in guillain-barre syndrome |
publisher |
S. Karger AG |
publishDate |
2018 |
url |
http://dx.doi.org/10.1159/000494261 https://www.karger.com/Article/Pdf/494261 |
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DML |
genre_facet |
DML |
op_source |
European Neurology volume 80, issue 1-2, page 100-105 ISSN 0014-3022 1421-9913 |
op_rights |
https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses |
op_doi |
https://doi.org/10.1159/000494261 |
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European Neurology |
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80 |
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1-2 |
container_start_page |
100 |
op_container_end_page |
105 |
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1801375045617975296 |