Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population

Background/Aims: Estimated glomerular filtration rate (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have in...

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Published in:Nephron
Main Authors: Eriksen, Bjørn Odvar, Løchen, Maja-Lisa, Arntzen, Kjell Arne, Bertelsen, Geir, Winther Eilertsen, Britt-Ann, von Hanno, Therese, Herder, Marit, Jenssen, Trond Geir, Mathisen, Ulla Dorte, Melsom, Toralf, Njølstad, Inger, Solbu, Marit D., Mathiesen, Ellisiv B.
Format: Article in Journal/Newspaper
Language:English
Published: S. Karger AG 2015
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Online Access:http://dx.doi.org/10.1159/000441092
https://www.karger.com/Article/Pdf/441092
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spelling crskarger:10.1159/000441092 2024-06-23T07:57:14+00:00 Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population Eriksen, Bjørn Odvar Løchen, Maja-Lisa Arntzen, Kjell Arne Bertelsen, Geir Winther Eilertsen, Britt-Ann von Hanno, Therese Herder, Marit Jenssen, Trond Geir Mathisen, Ulla Dorte Melsom, Toralf Njølstad, Inger Solbu, Marit D. Mathiesen, Ellisiv B. 2015 http://dx.doi.org/10.1159/000441092 https://www.karger.com/Article/Pdf/441092 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses Nephron volume 131, issue 3, page 175-184 ISSN 1660-8151 2235-3186 journal-article 2015 crskarger https://doi.org/10.1159/000441092 2024-06-05T04:07:17Z Background/Aims: Estimated glomerular filtration rate (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR and retinal vasculopathy, a marker of systemic microvasculopathy. Methods: Iohexol clearance and retinal photography were examined in the Renal Iohexol Clearance Survey in Tromsø 6, which consists of a representative sample of middle-aged persons from the general population. A total of 1,553 persons without self-reported kidney disease, cardiovascular disease or diabetes were investigated. Three eGFR equations based on creatinine and/or cystatin C from the Chronic Kidney Disease Epidemiology Collaboration were studied. Differences between eGFR and mGFR were analyzed with seemingly unrelated regression methods. Results: mGFR in the lowest quartile was associated with an increased multivariable-adjusted odds ratio of retinopathy (OR 1.86, 95% CI 1.16-2.97), but not with retinal artery or vein diameters. eGFR based on cystatin C (eGFR cys ) was consistently biased relative to mGFR in its associations with retinal vessel diameters across different models. eGFR based on creatinine (eGFR crea ) and eGFR based on both creatinine and cystatin C were also biased in several of these models (p < 0.05). For retinopathy, the differences between the 3 eGFR and mGFR measurements were not statistically significant. Conclusions: Low mGFR is associated with retinopathy in the general population. eGFR based on creatinine and/or cystatin C are not valid substitutes for mGFR in studies of the relationship between the retina and kidney function in healthy persons. Article in Journal/Newspaper Tromsø Karger Tromsø Nephron 131 3 175 184
institution Open Polar
collection Karger
op_collection_id crskarger
language English
description Background/Aims: Estimated glomerular filtration rate (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR and retinal vasculopathy, a marker of systemic microvasculopathy. Methods: Iohexol clearance and retinal photography were examined in the Renal Iohexol Clearance Survey in Tromsø 6, which consists of a representative sample of middle-aged persons from the general population. A total of 1,553 persons without self-reported kidney disease, cardiovascular disease or diabetes were investigated. Three eGFR equations based on creatinine and/or cystatin C from the Chronic Kidney Disease Epidemiology Collaboration were studied. Differences between eGFR and mGFR were analyzed with seemingly unrelated regression methods. Results: mGFR in the lowest quartile was associated with an increased multivariable-adjusted odds ratio of retinopathy (OR 1.86, 95% CI 1.16-2.97), but not with retinal artery or vein diameters. eGFR based on cystatin C (eGFR cys ) was consistently biased relative to mGFR in its associations with retinal vessel diameters across different models. eGFR based on creatinine (eGFR crea ) and eGFR based on both creatinine and cystatin C were also biased in several of these models (p < 0.05). For retinopathy, the differences between the 3 eGFR and mGFR measurements were not statistically significant. Conclusions: Low mGFR is associated with retinopathy in the general population. eGFR based on creatinine and/or cystatin C are not valid substitutes for mGFR in studies of the relationship between the retina and kidney function in healthy persons.
format Article in Journal/Newspaper
author Eriksen, Bjørn Odvar
Løchen, Maja-Lisa
Arntzen, Kjell Arne
Bertelsen, Geir
Winther Eilertsen, Britt-Ann
von Hanno, Therese
Herder, Marit
Jenssen, Trond Geir
Mathisen, Ulla Dorte
Melsom, Toralf
Njølstad, Inger
Solbu, Marit D.
Mathiesen, Ellisiv B.
spellingShingle Eriksen, Bjørn Odvar
Løchen, Maja-Lisa
Arntzen, Kjell Arne
Bertelsen, Geir
Winther Eilertsen, Britt-Ann
von Hanno, Therese
Herder, Marit
Jenssen, Trond Geir
Mathisen, Ulla Dorte
Melsom, Toralf
Njølstad, Inger
Solbu, Marit D.
Mathiesen, Ellisiv B.
Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population
author_facet Eriksen, Bjørn Odvar
Løchen, Maja-Lisa
Arntzen, Kjell Arne
Bertelsen, Geir
Winther Eilertsen, Britt-Ann
von Hanno, Therese
Herder, Marit
Jenssen, Trond Geir
Mathisen, Ulla Dorte
Melsom, Toralf
Njølstad, Inger
Solbu, Marit D.
Mathiesen, Ellisiv B.
author_sort Eriksen, Bjørn Odvar
title Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population
title_short Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population
title_full Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population
title_fullStr Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population
title_full_unstemmed Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population
title_sort estimated and measured gfr associate differently with retinal vasculopathy in the general population
publisher S. Karger AG
publishDate 2015
url http://dx.doi.org/10.1159/000441092
https://www.karger.com/Article/Pdf/441092
geographic Tromsø
geographic_facet Tromsø
genre Tromsø
genre_facet Tromsø
op_source Nephron
volume 131, issue 3, page 175-184
ISSN 1660-8151 2235-3186
op_rights https://www.karger.com/Services/SiteLicenses
https://www.karger.com/Services/SiteLicenses
op_doi https://doi.org/10.1159/000441092
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