Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population
Background/Aims: Estimated glomerular filtration rate (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have in...
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crskarger:10.1159/000441092 2024-06-23T07:57:14+00:00 Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population Eriksen, Bjørn Odvar Løchen, Maja-Lisa Arntzen, Kjell Arne Bertelsen, Geir Winther Eilertsen, Britt-Ann von Hanno, Therese Herder, Marit Jenssen, Trond Geir Mathisen, Ulla Dorte Melsom, Toralf Njølstad, Inger Solbu, Marit D. Mathiesen, Ellisiv B. 2015 http://dx.doi.org/10.1159/000441092 https://www.karger.com/Article/Pdf/441092 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses Nephron volume 131, issue 3, page 175-184 ISSN 1660-8151 2235-3186 journal-article 2015 crskarger https://doi.org/10.1159/000441092 2024-06-05T04:07:17Z Background/Aims: Estimated glomerular filtration rate (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR and retinal vasculopathy, a marker of systemic microvasculopathy. Methods: Iohexol clearance and retinal photography were examined in the Renal Iohexol Clearance Survey in Tromsø 6, which consists of a representative sample of middle-aged persons from the general population. A total of 1,553 persons without self-reported kidney disease, cardiovascular disease or diabetes were investigated. Three eGFR equations based on creatinine and/or cystatin C from the Chronic Kidney Disease Epidemiology Collaboration were studied. Differences between eGFR and mGFR were analyzed with seemingly unrelated regression methods. Results: mGFR in the lowest quartile was associated with an increased multivariable-adjusted odds ratio of retinopathy (OR 1.86, 95% CI 1.16-2.97), but not with retinal artery or vein diameters. eGFR based on cystatin C (eGFR cys ) was consistently biased relative to mGFR in its associations with retinal vessel diameters across different models. eGFR based on creatinine (eGFR crea ) and eGFR based on both creatinine and cystatin C were also biased in several of these models (p < 0.05). For retinopathy, the differences between the 3 eGFR and mGFR measurements were not statistically significant. Conclusions: Low mGFR is associated with retinopathy in the general population. eGFR based on creatinine and/or cystatin C are not valid substitutes for mGFR in studies of the relationship between the retina and kidney function in healthy persons. Article in Journal/Newspaper Tromsø Karger Tromsø Nephron 131 3 175 184 |
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language |
English |
description |
Background/Aims: Estimated glomerular filtration rate (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR and retinal vasculopathy, a marker of systemic microvasculopathy. Methods: Iohexol clearance and retinal photography were examined in the Renal Iohexol Clearance Survey in Tromsø 6, which consists of a representative sample of middle-aged persons from the general population. A total of 1,553 persons without self-reported kidney disease, cardiovascular disease or diabetes were investigated. Three eGFR equations based on creatinine and/or cystatin C from the Chronic Kidney Disease Epidemiology Collaboration were studied. Differences between eGFR and mGFR were analyzed with seemingly unrelated regression methods. Results: mGFR in the lowest quartile was associated with an increased multivariable-adjusted odds ratio of retinopathy (OR 1.86, 95% CI 1.16-2.97), but not with retinal artery or vein diameters. eGFR based on cystatin C (eGFR cys ) was consistently biased relative to mGFR in its associations with retinal vessel diameters across different models. eGFR based on creatinine (eGFR crea ) and eGFR based on both creatinine and cystatin C were also biased in several of these models (p < 0.05). For retinopathy, the differences between the 3 eGFR and mGFR measurements were not statistically significant. Conclusions: Low mGFR is associated with retinopathy in the general population. eGFR based on creatinine and/or cystatin C are not valid substitutes for mGFR in studies of the relationship between the retina and kidney function in healthy persons. |
format |
Article in Journal/Newspaper |
author |
Eriksen, Bjørn Odvar Løchen, Maja-Lisa Arntzen, Kjell Arne Bertelsen, Geir Winther Eilertsen, Britt-Ann von Hanno, Therese Herder, Marit Jenssen, Trond Geir Mathisen, Ulla Dorte Melsom, Toralf Njølstad, Inger Solbu, Marit D. Mathiesen, Ellisiv B. |
spellingShingle |
Eriksen, Bjørn Odvar Løchen, Maja-Lisa Arntzen, Kjell Arne Bertelsen, Geir Winther Eilertsen, Britt-Ann von Hanno, Therese Herder, Marit Jenssen, Trond Geir Mathisen, Ulla Dorte Melsom, Toralf Njølstad, Inger Solbu, Marit D. Mathiesen, Ellisiv B. Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population |
author_facet |
Eriksen, Bjørn Odvar Løchen, Maja-Lisa Arntzen, Kjell Arne Bertelsen, Geir Winther Eilertsen, Britt-Ann von Hanno, Therese Herder, Marit Jenssen, Trond Geir Mathisen, Ulla Dorte Melsom, Toralf Njølstad, Inger Solbu, Marit D. Mathiesen, Ellisiv B. |
author_sort |
Eriksen, Bjørn Odvar |
title |
Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population |
title_short |
Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population |
title_full |
Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population |
title_fullStr |
Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population |
title_full_unstemmed |
Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population |
title_sort |
estimated and measured gfr associate differently with retinal vasculopathy in the general population |
publisher |
S. Karger AG |
publishDate |
2015 |
url |
http://dx.doi.org/10.1159/000441092 https://www.karger.com/Article/Pdf/441092 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Nephron volume 131, issue 3, page 175-184 ISSN 1660-8151 2235-3186 |
op_rights |
https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses |
op_doi |
https://doi.org/10.1159/000441092 |
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Nephron |
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131 |
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175 |
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184 |
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