Oligometastatic Non-Small Cell Lung Cancer: A Significant Entity outside of Specialized Cancer Centers?
Objective: To report the incidence, patterns of care, and outcomes of oligometastatic non-small cell lung cancer (NSCLC) in a rural practice setting in Norway. Materials and Methods: A retrospective analysis was conducted of all patients with stage IV NSCLC at the initial diagnosis who received acti...
Published in: | Medical Principles and Practice |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
S. Karger AG
2014
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1159/000365634 https://www.karger.com/Article/Pdf/365634 |
id |
crskarger:10.1159/000365634 |
---|---|
record_format |
openpolar |
spelling |
crskarger:10.1159/000365634 2024-06-09T07:47:55+00:00 Oligometastatic Non-Small Cell Lung Cancer: A Significant Entity outside of Specialized Cancer Centers? Nieder, Carsten Tollåli, Terje Reigstad, Anne Pawinski, Adam Haukland, Ellinor Dalhaug, Astrid 2014 http://dx.doi.org/10.1159/000365634 https://www.karger.com/Article/Pdf/365634 en eng S. Karger AG https://creativecommons.org/licenses/by-nc/3.0/ https://creativecommons.org/licenses/by-nc/3.0/ Medical Principles and Practice volume 23, issue 6, page 526-531 ISSN 1011-7571 1423-0151 journal-article 2014 crskarger https://doi.org/10.1159/000365634 2024-05-15T13:30:13Z Objective: To report the incidence, patterns of care, and outcomes of oligometastatic non-small cell lung cancer (NSCLC) in a rural practice setting in Norway. Materials and Methods: A retrospective analysis was conducted of all patients with stage IV NSCLC at the initial diagnosis who received active treatment in the central part of Nordland, a rural county in northern Norway, during the period of 2006-2012. We analyzed overall survival and prognostic factors. Results: The initial study population included 113 patients with stage IV disease who received active therapy; of these, 23 (20%) had oligometastatic spread (a maximum of 3 metastases to 1 organ). The median age was 71 years. Of the 23 patients, 16 (70%) did not receive radical or at least moderately aggressive local treatment for their thoracic disease. Of the remaining 7 patients, 4 (17.4%) did not receive systemic therapy. The median actuarial survival was 5.6 months in patients with more advanced metastases and 11.7 months in those with oligometastases (p = 0.03). Significant differences were also seen between the 2 oligometastatic patient groups with and without more intense thoracic treatment (median 19.7 vs. 7.6 months, p = 0.004). Further significant predictors of survival in patients with oligometastases were nodal stage (p = 0.028) and weight loss (p = 0.045). Trends were seen for T stage (p = 0.058) and performance status (p = 0.07). Conclusion: Oligometastatic NSCLC was diagnosed in a relevant proportion of patients; therefore, warranting prospective studies are recommended. Such studies are also needed to confirm the treatment-dependent survival differences observed in our patient population. Article in Journal/Newspaper Nordland Nordland Northern Norway Nordland Karger Norway Medical Principles and Practice 23 6 526 531 |
institution |
Open Polar |
collection |
Karger |
op_collection_id |
crskarger |
language |
English |
description |
Objective: To report the incidence, patterns of care, and outcomes of oligometastatic non-small cell lung cancer (NSCLC) in a rural practice setting in Norway. Materials and Methods: A retrospective analysis was conducted of all patients with stage IV NSCLC at the initial diagnosis who received active treatment in the central part of Nordland, a rural county in northern Norway, during the period of 2006-2012. We analyzed overall survival and prognostic factors. Results: The initial study population included 113 patients with stage IV disease who received active therapy; of these, 23 (20%) had oligometastatic spread (a maximum of 3 metastases to 1 organ). The median age was 71 years. Of the 23 patients, 16 (70%) did not receive radical or at least moderately aggressive local treatment for their thoracic disease. Of the remaining 7 patients, 4 (17.4%) did not receive systemic therapy. The median actuarial survival was 5.6 months in patients with more advanced metastases and 11.7 months in those with oligometastases (p = 0.03). Significant differences were also seen between the 2 oligometastatic patient groups with and without more intense thoracic treatment (median 19.7 vs. 7.6 months, p = 0.004). Further significant predictors of survival in patients with oligometastases were nodal stage (p = 0.028) and weight loss (p = 0.045). Trends were seen for T stage (p = 0.058) and performance status (p = 0.07). Conclusion: Oligometastatic NSCLC was diagnosed in a relevant proportion of patients; therefore, warranting prospective studies are recommended. Such studies are also needed to confirm the treatment-dependent survival differences observed in our patient population. |
format |
Article in Journal/Newspaper |
author |
Nieder, Carsten Tollåli, Terje Reigstad, Anne Pawinski, Adam Haukland, Ellinor Dalhaug, Astrid |
spellingShingle |
Nieder, Carsten Tollåli, Terje Reigstad, Anne Pawinski, Adam Haukland, Ellinor Dalhaug, Astrid Oligometastatic Non-Small Cell Lung Cancer: A Significant Entity outside of Specialized Cancer Centers? |
author_facet |
Nieder, Carsten Tollåli, Terje Reigstad, Anne Pawinski, Adam Haukland, Ellinor Dalhaug, Astrid |
author_sort |
Nieder, Carsten |
title |
Oligometastatic Non-Small Cell Lung Cancer: A Significant Entity outside of Specialized Cancer Centers? |
title_short |
Oligometastatic Non-Small Cell Lung Cancer: A Significant Entity outside of Specialized Cancer Centers? |
title_full |
Oligometastatic Non-Small Cell Lung Cancer: A Significant Entity outside of Specialized Cancer Centers? |
title_fullStr |
Oligometastatic Non-Small Cell Lung Cancer: A Significant Entity outside of Specialized Cancer Centers? |
title_full_unstemmed |
Oligometastatic Non-Small Cell Lung Cancer: A Significant Entity outside of Specialized Cancer Centers? |
title_sort |
oligometastatic non-small cell lung cancer: a significant entity outside of specialized cancer centers? |
publisher |
S. Karger AG |
publishDate |
2014 |
url |
http://dx.doi.org/10.1159/000365634 https://www.karger.com/Article/Pdf/365634 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Nordland Nordland Northern Norway Nordland |
genre_facet |
Nordland Nordland Northern Norway Nordland |
op_source |
Medical Principles and Practice volume 23, issue 6, page 526-531 ISSN 1011-7571 1423-0151 |
op_rights |
https://creativecommons.org/licenses/by-nc/3.0/ https://creativecommons.org/licenses/by-nc/3.0/ |
op_doi |
https://doi.org/10.1159/000365634 |
container_title |
Medical Principles and Practice |
container_volume |
23 |
container_issue |
6 |
container_start_page |
526 |
op_container_end_page |
531 |
_version_ |
1801379391066865664 |