BRCA1 and BRCA2 Mutations in the Ovarian Cancer Population across Race and Ethnicity: Special Reference to Asia
Objective: To evaluate the prevalence and spectrum of BRCA mutations among ovarian carcinoma patients of different races and ethnicity with special reference to Asia. Methods: A systematic review of the literature was undertaken to evaluate the prevalence of BRCA mutations among people belonging to...
Published in: | Oncology |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
S. Karger AG
2013
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1159/000346593 https://www.karger.com/Article/Pdf/346593 |
id |
crskarger:10.1159/000346593 |
---|---|
record_format |
openpolar |
spelling |
crskarger:10.1159/000346593 2024-06-09T07:47:11+00:00 BRCA1 and BRCA2 Mutations in the Ovarian Cancer Population across Race and Ethnicity: Special Reference to Asia Shanmughapriya, Santhanam Nachiappan, Vasanthi Natarajaseenivasan, Kalimuthusamy 2013 http://dx.doi.org/10.1159/000346593 https://www.karger.com/Article/Pdf/346593 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses Oncology volume 84, issue 4, page 226-232 ISSN 0030-2414 1423-0232 journal-article 2013 crskarger https://doi.org/10.1159/000346593 2024-05-15T13:30:49Z Objective: To evaluate the prevalence and spectrum of BRCA mutations among ovarian carcinoma patients of different races and ethnicity with special reference to Asia. Methods: A systematic review of the literature was undertaken to evaluate the prevalence of BRCA mutations among people belonging to different races. The electronic search strategy was developed specifically for the different databases concerned and via cross-referencing. Results: The frequency of BRCA1 and BRCA2 mutations ranged from 1.1 to 39.7 and from 0 to 13.9, respectively. BRCA1 mutations are more common among ovarian cancer cases than BRCA2 mutations, although the ratio of BRCA1 to BRCA2 varies between populations. The Swedish and Indian populations showed 12 and 7 times as many BRCA1 as BRCA2 mutations, respectively, whilst in a study from Iceland the ratio was 0.5:1. These wide-ranging estimates of the mutation prevalence suggest genetic heterogeneity between different populations. Conclusion: The ability to identify BRCA1/2 mutations was found to be successful in the clinical management of ovarian cancer. Given the implications for clinical care and for advances in cancer prevention, identifying racial difference in genetic or lifestyle factors, which may modify the cancer risk due to BRCA1/2 mutations, is a high priority for future research. Article in Journal/Newspaper Iceland Karger Indian Oncology 84 4 226 232 |
institution |
Open Polar |
collection |
Karger |
op_collection_id |
crskarger |
language |
English |
description |
Objective: To evaluate the prevalence and spectrum of BRCA mutations among ovarian carcinoma patients of different races and ethnicity with special reference to Asia. Methods: A systematic review of the literature was undertaken to evaluate the prevalence of BRCA mutations among people belonging to different races. The electronic search strategy was developed specifically for the different databases concerned and via cross-referencing. Results: The frequency of BRCA1 and BRCA2 mutations ranged from 1.1 to 39.7 and from 0 to 13.9, respectively. BRCA1 mutations are more common among ovarian cancer cases than BRCA2 mutations, although the ratio of BRCA1 to BRCA2 varies between populations. The Swedish and Indian populations showed 12 and 7 times as many BRCA1 as BRCA2 mutations, respectively, whilst in a study from Iceland the ratio was 0.5:1. These wide-ranging estimates of the mutation prevalence suggest genetic heterogeneity between different populations. Conclusion: The ability to identify BRCA1/2 mutations was found to be successful in the clinical management of ovarian cancer. Given the implications for clinical care and for advances in cancer prevention, identifying racial difference in genetic or lifestyle factors, which may modify the cancer risk due to BRCA1/2 mutations, is a high priority for future research. |
format |
Article in Journal/Newspaper |
author |
Shanmughapriya, Santhanam Nachiappan, Vasanthi Natarajaseenivasan, Kalimuthusamy |
spellingShingle |
Shanmughapriya, Santhanam Nachiappan, Vasanthi Natarajaseenivasan, Kalimuthusamy BRCA1 and BRCA2 Mutations in the Ovarian Cancer Population across Race and Ethnicity: Special Reference to Asia |
author_facet |
Shanmughapriya, Santhanam Nachiappan, Vasanthi Natarajaseenivasan, Kalimuthusamy |
author_sort |
Shanmughapriya, Santhanam |
title |
BRCA1 and BRCA2 Mutations in the Ovarian Cancer Population across Race and Ethnicity: Special Reference to Asia |
title_short |
BRCA1 and BRCA2 Mutations in the Ovarian Cancer Population across Race and Ethnicity: Special Reference to Asia |
title_full |
BRCA1 and BRCA2 Mutations in the Ovarian Cancer Population across Race and Ethnicity: Special Reference to Asia |
title_fullStr |
BRCA1 and BRCA2 Mutations in the Ovarian Cancer Population across Race and Ethnicity: Special Reference to Asia |
title_full_unstemmed |
BRCA1 and BRCA2 Mutations in the Ovarian Cancer Population across Race and Ethnicity: Special Reference to Asia |
title_sort |
brca1 and brca2 mutations in the ovarian cancer population across race and ethnicity: special reference to asia |
publisher |
S. Karger AG |
publishDate |
2013 |
url |
http://dx.doi.org/10.1159/000346593 https://www.karger.com/Article/Pdf/346593 |
geographic |
Indian |
geographic_facet |
Indian |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Oncology volume 84, issue 4, page 226-232 ISSN 0030-2414 1423-0232 |
op_rights |
https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses |
op_doi |
https://doi.org/10.1159/000346593 |
container_title |
Oncology |
container_volume |
84 |
container_issue |
4 |
container_start_page |
226 |
op_container_end_page |
232 |
_version_ |
1801378131015106560 |