Wintering in Antarctica: Impact on Immune Response of Indian Expeditioners
The immune system is one of the major thrust areas in understanding the effects of adverse climatic conditions on human health. Exposure to the Antarctic environment, such as isolation, cold, UV radiations, magnetic field, blizzards, circadian biorhythms, and fear of the unknown, modify various comp...
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Online Access: | http://dx.doi.org/10.1159/000339512 https://www.karger.com/Article/Pdf/339512 |
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crskarger:10.1159/000339512 2024-06-09T07:39:11+00:00 Wintering in Antarctica: Impact on Immune Response of Indian Expeditioners Yadav, Anand Prakash Mishra, Kamla Prasad Ganju, Lilly Singh, Shashi Bala 2012 http://dx.doi.org/10.1159/000339512 https://www.karger.com/Article/Pdf/339512 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses Neuroimmunomodulation volume 19, issue 6, page 327-333 ISSN 1021-7401 1423-0216 journal-article 2012 crskarger https://doi.org/10.1159/000339512 2024-05-15T13:29:32Z The immune system is one of the major thrust areas in understanding the effects of adverse climatic conditions on human health. Exposure to the Antarctic environment, such as isolation, cold, UV radiations, magnetic field, blizzards, circadian biorhythms, and fear of the unknown, modify various components of the immune system. Members of Antarctic expeditions suffer significant emotional strain as a result of physical isolation and social deprivation. The present study was performed on winter team members of the 28th Indian Scientific Expedition. In this study, different immunological parameters, which mainly include cytokines (TNF-α, IFN-γ, TGF-β, and IL-4), chemokine MIP-1α, immunoglobulins (IgA, IgM and IgG), cortisol and netrin-1, were assayed in sera by ELISA. Results showed that TNF-α and MIP-1α levels were significantly increased in March, May and August while IFN-γ levels were increased in March and May while TGF-β levels showed a significant decrease in March and May. Serum IgA levels were significantly increased during the entire period of the stressful expedition. Therefore, the present study suggests that serum IgA could be a potential biomarker for extreme environmental conditions. Article in Journal/Newspaper Antarc* Antarctic Antarctica Karger Antarctic Indian The Antarctic Neuroimmunomodulation 19 6 327 333 |
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The immune system is one of the major thrust areas in understanding the effects of adverse climatic conditions on human health. Exposure to the Antarctic environment, such as isolation, cold, UV radiations, magnetic field, blizzards, circadian biorhythms, and fear of the unknown, modify various components of the immune system. Members of Antarctic expeditions suffer significant emotional strain as a result of physical isolation and social deprivation. The present study was performed on winter team members of the 28th Indian Scientific Expedition. In this study, different immunological parameters, which mainly include cytokines (TNF-α, IFN-γ, TGF-β, and IL-4), chemokine MIP-1α, immunoglobulins (IgA, IgM and IgG), cortisol and netrin-1, were assayed in sera by ELISA. Results showed that TNF-α and MIP-1α levels were significantly increased in March, May and August while IFN-γ levels were increased in March and May while TGF-β levels showed a significant decrease in March and May. Serum IgA levels were significantly increased during the entire period of the stressful expedition. Therefore, the present study suggests that serum IgA could be a potential biomarker for extreme environmental conditions. |
format |
Article in Journal/Newspaper |
author |
Yadav, Anand Prakash Mishra, Kamla Prasad Ganju, Lilly Singh, Shashi Bala |
spellingShingle |
Yadav, Anand Prakash Mishra, Kamla Prasad Ganju, Lilly Singh, Shashi Bala Wintering in Antarctica: Impact on Immune Response of Indian Expeditioners |
author_facet |
Yadav, Anand Prakash Mishra, Kamla Prasad Ganju, Lilly Singh, Shashi Bala |
author_sort |
Yadav, Anand Prakash |
title |
Wintering in Antarctica: Impact on Immune Response of Indian Expeditioners |
title_short |
Wintering in Antarctica: Impact on Immune Response of Indian Expeditioners |
title_full |
Wintering in Antarctica: Impact on Immune Response of Indian Expeditioners |
title_fullStr |
Wintering in Antarctica: Impact on Immune Response of Indian Expeditioners |
title_full_unstemmed |
Wintering in Antarctica: Impact on Immune Response of Indian Expeditioners |
title_sort |
wintering in antarctica: impact on immune response of indian expeditioners |
publisher |
S. Karger AG |
publishDate |
2012 |
url |
http://dx.doi.org/10.1159/000339512 https://www.karger.com/Article/Pdf/339512 |
geographic |
Antarctic Indian The Antarctic |
geographic_facet |
Antarctic Indian The Antarctic |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_source |
Neuroimmunomodulation volume 19, issue 6, page 327-333 ISSN 1021-7401 1423-0216 |
op_rights |
https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses |
op_doi |
https://doi.org/10.1159/000339512 |
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Neuroimmunomodulation |
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19 |
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6 |
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327 |
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333 |
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