Gender Difference in the Prediction of Weight Loss by Leptin among Overweight Adults
Background/Aim: Leptin plays an important role in energy metabolism. The primary objective of the study was to investigate whether baseline leptin levels predict weight loss during a dietary intervention in overweight and obese individuals. Methods: A total of 324 individuals (138 men and 186 women,...
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Online Access: | http://dx.doi.org/10.1159/000281833 https://www.karger.com/Article/Pdf/281833 |
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crskarger:10.1159/000281833 2024-06-09T07:47:11+00:00 Gender Difference in the Prediction of Weight Loss by Leptin among Overweight Adults Ramel, Alfons Arnarson, Atli Parra, Dolores Kiely, Mairead Bandarra, Narcisa M. Martínez, J. Alfredo Thorsdottir, Inga 2010 http://dx.doi.org/10.1159/000281833 https://www.karger.com/Article/Pdf/281833 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses Annals of Nutrition and Metabolism volume 56, issue 3, page 190-197 ISSN 0250-6807 1421-9697 journal-article 2010 crskarger https://doi.org/10.1159/000281833 2024-05-15T13:30:23Z Background/Aim: Leptin plays an important role in energy metabolism. The primary objective of the study was to investigate whether baseline leptin levels predict weight loss during a dietary intervention in overweight and obese individuals. Methods: A total of 324 individuals (138 men and 186 women, aged 20–40 years, BMI 27.5–32.5) were recruited in Iceland, Ireland and Spain. The intervention lasted for 8 consecutive weeks, and subjects were instructed to follow a diet, energy restricted by 30%. Anthropometric variables were assessed before and after the intervention. Leptin concentration was measured at baseline and corrected for fat mass. Linear models were used to find out which variables predicted weight loss. Results: At end point, significant weight loss was observed (5.16 ± 3.06 kg, p < 0.001). High baseline leptin concentrations were a significant negative predictor of weight loss in men (p = 0.028), with a predicted difference of 1.8 kg between the lowest and highest leptin quartile. Conclusion: Our study underlines the importance of leptin in energy metabolism. Plasma leptin concentrations at baseline are a predictor of weight loss in overweight men after an 8-week dietary intervention. The same effect was not observed in overweight women, which suggests that the role of leptin in the regulation of weight is gender specific. Article in Journal/Newspaper Iceland Karger Annals of Nutrition and Metabolism 56 3 190 197 |
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Background/Aim: Leptin plays an important role in energy metabolism. The primary objective of the study was to investigate whether baseline leptin levels predict weight loss during a dietary intervention in overweight and obese individuals. Methods: A total of 324 individuals (138 men and 186 women, aged 20–40 years, BMI 27.5–32.5) were recruited in Iceland, Ireland and Spain. The intervention lasted for 8 consecutive weeks, and subjects were instructed to follow a diet, energy restricted by 30%. Anthropometric variables were assessed before and after the intervention. Leptin concentration was measured at baseline and corrected for fat mass. Linear models were used to find out which variables predicted weight loss. Results: At end point, significant weight loss was observed (5.16 ± 3.06 kg, p < 0.001). High baseline leptin concentrations were a significant negative predictor of weight loss in men (p = 0.028), with a predicted difference of 1.8 kg between the lowest and highest leptin quartile. Conclusion: Our study underlines the importance of leptin in energy metabolism. Plasma leptin concentrations at baseline are a predictor of weight loss in overweight men after an 8-week dietary intervention. The same effect was not observed in overweight women, which suggests that the role of leptin in the regulation of weight is gender specific. |
format |
Article in Journal/Newspaper |
author |
Ramel, Alfons Arnarson, Atli Parra, Dolores Kiely, Mairead Bandarra, Narcisa M. Martínez, J. Alfredo Thorsdottir, Inga |
spellingShingle |
Ramel, Alfons Arnarson, Atli Parra, Dolores Kiely, Mairead Bandarra, Narcisa M. Martínez, J. Alfredo Thorsdottir, Inga Gender Difference in the Prediction of Weight Loss by Leptin among Overweight Adults |
author_facet |
Ramel, Alfons Arnarson, Atli Parra, Dolores Kiely, Mairead Bandarra, Narcisa M. Martínez, J. Alfredo Thorsdottir, Inga |
author_sort |
Ramel, Alfons |
title |
Gender Difference in the Prediction of Weight Loss by Leptin among Overweight Adults |
title_short |
Gender Difference in the Prediction of Weight Loss by Leptin among Overweight Adults |
title_full |
Gender Difference in the Prediction of Weight Loss by Leptin among Overweight Adults |
title_fullStr |
Gender Difference in the Prediction of Weight Loss by Leptin among Overweight Adults |
title_full_unstemmed |
Gender Difference in the Prediction of Weight Loss by Leptin among Overweight Adults |
title_sort |
gender difference in the prediction of weight loss by leptin among overweight adults |
publisher |
S. Karger AG |
publishDate |
2010 |
url |
http://dx.doi.org/10.1159/000281833 https://www.karger.com/Article/Pdf/281833 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Annals of Nutrition and Metabolism volume 56, issue 3, page 190-197 ISSN 0250-6807 1421-9697 |
op_rights |
https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses |
op_doi |
https://doi.org/10.1159/000281833 |
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Annals of Nutrition and Metabolism |
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56 |
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3 |
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190 |
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197 |
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1801378123747426304 |