Prospective Randomized Study Comparing the Debriding Effect of Krill Enzymes and a Non-Enzymatic Treatment in Venous Leg Ulcers
The debriding potential of a recently discovered potent enzyme preparation derived from Antarctic krill ( Euphausia superba) was compared to a routine non-enzymatic treatment in 31 patients with venous leg ulcers. To assure a reliable interpretation of the cleaning effect, computer image analysis wa...
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Language: | English |
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1990
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Online Access: | http://dx.doi.org/10.1159/000247828 https://www.karger.com/Article/Pdf/247828 |
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crskarger:10.1159/000247828 2024-06-09T07:39:02+00:00 Prospective Randomized Study Comparing the Debriding Effect of Krill Enzymes and a Non-Enzymatic Treatment in Venous Leg Ulcers Westerhof, W. van Ginkel, C.J.W. Cohen, E.B. Mekkes, J.R. 1990 http://dx.doi.org/10.1159/000247828 https://www.karger.com/Article/Pdf/247828 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses Dermatology volume 181, issue 4, page 293-297 ISSN 1018-8665 1421-9832 journal-article 1990 crskarger https://doi.org/10.1159/000247828 2024-05-15T13:30:15Z The debriding potential of a recently discovered potent enzyme preparation derived from Antarctic krill ( Euphausia superba) was compared to a routine non-enzymatic treatment in 31 patients with venous leg ulcers. To assure a reliable interpretation of the cleaning effect, computer image analysis was used to measure wound size and the amount of debris day by day. Krill enzyme treatment was significantly (p < 0.01) better than the non-enzymatic treatment. The necrotic area diminished by 53% while in the control group no reduction of the necrotic area was observed in 7 days. The median time required to clean the ulcer was 7 days in the krill group and 10 days in the control group. Afterwards the ulcers were grafted with autologous skin biopsies, which yielded similar results in both groups. No side effects were observed. It was concluded that krill enzymes fulfil criteria for effective debridement of venous leg ulcers. Article in Journal/Newspaper Antarc* Antarctic Antarctic Krill Euphausia superba Karger Antarctic Dermatology 181 4 293 297 |
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crskarger |
language |
English |
description |
The debriding potential of a recently discovered potent enzyme preparation derived from Antarctic krill ( Euphausia superba) was compared to a routine non-enzymatic treatment in 31 patients with venous leg ulcers. To assure a reliable interpretation of the cleaning effect, computer image analysis was used to measure wound size and the amount of debris day by day. Krill enzyme treatment was significantly (p < 0.01) better than the non-enzymatic treatment. The necrotic area diminished by 53% while in the control group no reduction of the necrotic area was observed in 7 days. The median time required to clean the ulcer was 7 days in the krill group and 10 days in the control group. Afterwards the ulcers were grafted with autologous skin biopsies, which yielded similar results in both groups. No side effects were observed. It was concluded that krill enzymes fulfil criteria for effective debridement of venous leg ulcers. |
format |
Article in Journal/Newspaper |
author |
Westerhof, W. van Ginkel, C.J.W. Cohen, E.B. Mekkes, J.R. |
spellingShingle |
Westerhof, W. van Ginkel, C.J.W. Cohen, E.B. Mekkes, J.R. Prospective Randomized Study Comparing the Debriding Effect of Krill Enzymes and a Non-Enzymatic Treatment in Venous Leg Ulcers |
author_facet |
Westerhof, W. van Ginkel, C.J.W. Cohen, E.B. Mekkes, J.R. |
author_sort |
Westerhof, W. |
title |
Prospective Randomized Study Comparing the Debriding Effect of Krill Enzymes and a Non-Enzymatic Treatment in Venous Leg Ulcers |
title_short |
Prospective Randomized Study Comparing the Debriding Effect of Krill Enzymes and a Non-Enzymatic Treatment in Venous Leg Ulcers |
title_full |
Prospective Randomized Study Comparing the Debriding Effect of Krill Enzymes and a Non-Enzymatic Treatment in Venous Leg Ulcers |
title_fullStr |
Prospective Randomized Study Comparing the Debriding Effect of Krill Enzymes and a Non-Enzymatic Treatment in Venous Leg Ulcers |
title_full_unstemmed |
Prospective Randomized Study Comparing the Debriding Effect of Krill Enzymes and a Non-Enzymatic Treatment in Venous Leg Ulcers |
title_sort |
prospective randomized study comparing the debriding effect of krill enzymes and a non-enzymatic treatment in venous leg ulcers |
publisher |
S. Karger AG |
publishDate |
1990 |
url |
http://dx.doi.org/10.1159/000247828 https://www.karger.com/Article/Pdf/247828 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill Euphausia superba |
genre_facet |
Antarc* Antarctic Antarctic Krill Euphausia superba |
op_source |
Dermatology volume 181, issue 4, page 293-297 ISSN 1018-8665 1421-9832 |
op_rights |
https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses |
op_doi |
https://doi.org/10.1159/000247828 |
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Dermatology |
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181 |
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4 |
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293 |
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297 |
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