C-Reactive Protein Is a Determinant of First-Ever Stroke: Prospective Nested Case-Referent Study
Background and Purpose: C-reactive protein (CRP) is a determinant of stroke, but there are no prospective studies on CRP and first ischemic stroke divided into etiologic subtypes. Our primary aim was to study CRP as a determinant of ischemic stroke, classified according to Trial of ORG 10172 in Acut...
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Online Access: | http://dx.doi.org/10.1159/000214217 https://www.karger.com/Article/Pdf/214217 |
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crskarger:10.1159/000214217 2024-09-15T18:26:11+00:00 C-Reactive Protein Is a Determinant of First-Ever Stroke: Prospective Nested Case-Referent Study Andersson, Jonas Johansson, Lars Ladenvall, Per Wiklund, Per-Gunnar Stegmayr, Birgitta Jern, Christina Boman, Kurt 2009 http://dx.doi.org/10.1159/000214217 https://www.karger.com/Article/Pdf/214217 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses Cerebrovascular Diseases volume 27, issue 6, page 544-551 ISSN 1015-9770 1421-9786 journal-article 2009 crskarger https://doi.org/10.1159/000214217 2024-07-24T04:06:10Z Background and Purpose: C-reactive protein (CRP) is a determinant of stroke, but there are no prospective studies on CRP and first ischemic stroke divided into etiologic subtypes. Our primary aim was to study CRP as a determinant of ischemic stroke, classified according to Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria, and intracerebral hemorrhage (ICH) in a prospective study. A secondary aim was to study the relationship between the 1444C>T polymorphism, plasma levels of CRP and stroke. Methods: The study was a prospective population-based case-referent study nested within the Northern Sweden Cohorts. We defined 308 cases of ischemic stroke and 61 ICH. Two controls for each case were defined from the same cohort. Results: The OR for the highest (>3 mg/l) versus lowest group (<1 mg/l) of CRP was 2.58 (95% CI 1.74–3.84) for ischemic stroke and 1.63 (95% CI 0.67–3.93) for ICH. In a multivariate model including traditional risk factors, CRP remained associated with ischemic stroke (OR 2.06; 95% CI 1.29–3.29). Small-vessel disease was associated with CRP in the multivariate model (OR 3.88; 95% CI 1.10–13.7). The CRP 1444 (CC/CT vs. TT) polymorphism was associated with plasma levels of CRP but neither with ischemic stroke nor with ICH. Conclusions: This prospective population-based study shows that CRP is significantly associated with the risk of having a first ischemic stroke, especially for small-vessel disease. No significant associations were found between the CRP 1444C>T polymorphism and any stroke subtype. Article in Journal/Newspaper Northern Sweden Karger Cerebrovascular Diseases 27 6 544 551 |
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English |
description |
Background and Purpose: C-reactive protein (CRP) is a determinant of stroke, but there are no prospective studies on CRP and first ischemic stroke divided into etiologic subtypes. Our primary aim was to study CRP as a determinant of ischemic stroke, classified according to Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria, and intracerebral hemorrhage (ICH) in a prospective study. A secondary aim was to study the relationship between the 1444C>T polymorphism, plasma levels of CRP and stroke. Methods: The study was a prospective population-based case-referent study nested within the Northern Sweden Cohorts. We defined 308 cases of ischemic stroke and 61 ICH. Two controls for each case were defined from the same cohort. Results: The OR for the highest (>3 mg/l) versus lowest group (<1 mg/l) of CRP was 2.58 (95% CI 1.74–3.84) for ischemic stroke and 1.63 (95% CI 0.67–3.93) for ICH. In a multivariate model including traditional risk factors, CRP remained associated with ischemic stroke (OR 2.06; 95% CI 1.29–3.29). Small-vessel disease was associated with CRP in the multivariate model (OR 3.88; 95% CI 1.10–13.7). The CRP 1444 (CC/CT vs. TT) polymorphism was associated with plasma levels of CRP but neither with ischemic stroke nor with ICH. Conclusions: This prospective population-based study shows that CRP is significantly associated with the risk of having a first ischemic stroke, especially for small-vessel disease. No significant associations were found between the CRP 1444C>T polymorphism and any stroke subtype. |
format |
Article in Journal/Newspaper |
author |
Andersson, Jonas Johansson, Lars Ladenvall, Per Wiklund, Per-Gunnar Stegmayr, Birgitta Jern, Christina Boman, Kurt |
spellingShingle |
Andersson, Jonas Johansson, Lars Ladenvall, Per Wiklund, Per-Gunnar Stegmayr, Birgitta Jern, Christina Boman, Kurt C-Reactive Protein Is a Determinant of First-Ever Stroke: Prospective Nested Case-Referent Study |
author_facet |
Andersson, Jonas Johansson, Lars Ladenvall, Per Wiklund, Per-Gunnar Stegmayr, Birgitta Jern, Christina Boman, Kurt |
author_sort |
Andersson, Jonas |
title |
C-Reactive Protein Is a Determinant of First-Ever Stroke: Prospective Nested Case-Referent Study |
title_short |
C-Reactive Protein Is a Determinant of First-Ever Stroke: Prospective Nested Case-Referent Study |
title_full |
C-Reactive Protein Is a Determinant of First-Ever Stroke: Prospective Nested Case-Referent Study |
title_fullStr |
C-Reactive Protein Is a Determinant of First-Ever Stroke: Prospective Nested Case-Referent Study |
title_full_unstemmed |
C-Reactive Protein Is a Determinant of First-Ever Stroke: Prospective Nested Case-Referent Study |
title_sort |
c-reactive protein is a determinant of first-ever stroke: prospective nested case-referent study |
publisher |
S. Karger AG |
publishDate |
2009 |
url |
http://dx.doi.org/10.1159/000214217 https://www.karger.com/Article/Pdf/214217 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Cerebrovascular Diseases volume 27, issue 6, page 544-551 ISSN 1015-9770 1421-9786 |
op_rights |
https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses |
op_doi |
https://doi.org/10.1159/000214217 |
container_title |
Cerebrovascular Diseases |
container_volume |
27 |
container_issue |
6 |
container_start_page |
544 |
op_container_end_page |
551 |
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1810466636439748608 |