Melanocytes – A UV-Sensitive Neural Network and Circadian Rhythms
The melanocytes are acutely sensitive to a single pulse of UV and express neural differentiation. The present work was undertaken to observe whether the melanocyte can sense variations in the duration of UV exposure. Whole skin organ cultures from marginal zone in vitiligo were exposed to a single p...
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Language: | English |
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S. Karger AG
1992
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Online Access: | http://dx.doi.org/10.1159/000147326 https://www.karger.com/Article/Pdf/147326 |
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crskarger:10.1159/000147326 2024-09-30T14:41:35+00:00 Melanocytes – A UV-Sensitive Neural Network and Circadian Rhythms Iyengar, B. 1992 http://dx.doi.org/10.1159/000147326 https://www.karger.com/Article/Pdf/147326 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses Cells Tissues Organs volume 144, issue 4, page 332-335 ISSN 1422-6405 1422-6421 journal-article 1992 crskarger https://doi.org/10.1159/000147326 2024-09-18T04:06:23Z The melanocytes are acutely sensitive to a single pulse of UV and express neural differentiation. The present work was undertaken to observe whether the melanocyte can sense variations in the duration of UV exposure. Whole skin organ cultures from marginal zone in vitiligo were exposed to a single pulse of UV, 30, 60, 90 and 120 s each. Catecholoxidase levels in the marginal melanocytes and the volume of melanocytes were used to calculate and quantitate the changes in enzyme production. The melanocytes’ dendricity, volume and enzyme production increases with the duration of UV exposure. This sensitivity of the marginal melanocytes, to changes in the duration of UV exposure, simulates the coat color changes in weasels and the polar fox exposed to extreme variations in the day/night cycles. The UV response is associated with proliferation of melanocytes as it is G 2 -phase dependent. Thus the melanocytes form a UV-sensitive neural network responding to annual changes in the photoperiodicity. Article in Journal/Newspaper polar fox Karger Cells Tissues Organs 144 4 332 335 |
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language |
English |
description |
The melanocytes are acutely sensitive to a single pulse of UV and express neural differentiation. The present work was undertaken to observe whether the melanocyte can sense variations in the duration of UV exposure. Whole skin organ cultures from marginal zone in vitiligo were exposed to a single pulse of UV, 30, 60, 90 and 120 s each. Catecholoxidase levels in the marginal melanocytes and the volume of melanocytes were used to calculate and quantitate the changes in enzyme production. The melanocytes’ dendricity, volume and enzyme production increases with the duration of UV exposure. This sensitivity of the marginal melanocytes, to changes in the duration of UV exposure, simulates the coat color changes in weasels and the polar fox exposed to extreme variations in the day/night cycles. The UV response is associated with proliferation of melanocytes as it is G 2 -phase dependent. Thus the melanocytes form a UV-sensitive neural network responding to annual changes in the photoperiodicity. |
format |
Article in Journal/Newspaper |
author |
Iyengar, B. |
spellingShingle |
Iyengar, B. Melanocytes – A UV-Sensitive Neural Network and Circadian Rhythms |
author_facet |
Iyengar, B. |
author_sort |
Iyengar, B. |
title |
Melanocytes – A UV-Sensitive Neural Network and Circadian Rhythms |
title_short |
Melanocytes – A UV-Sensitive Neural Network and Circadian Rhythms |
title_full |
Melanocytes – A UV-Sensitive Neural Network and Circadian Rhythms |
title_fullStr |
Melanocytes – A UV-Sensitive Neural Network and Circadian Rhythms |
title_full_unstemmed |
Melanocytes – A UV-Sensitive Neural Network and Circadian Rhythms |
title_sort |
melanocytes – a uv-sensitive neural network and circadian rhythms |
publisher |
S. Karger AG |
publishDate |
1992 |
url |
http://dx.doi.org/10.1159/000147326 https://www.karger.com/Article/Pdf/147326 |
genre |
polar fox |
genre_facet |
polar fox |
op_source |
Cells Tissues Organs volume 144, issue 4, page 332-335 ISSN 1422-6405 1422-6421 |
op_rights |
https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses |
op_doi |
https://doi.org/10.1159/000147326 |
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Cells Tissues Organs |
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144 |
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4 |
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332 |
op_container_end_page |
335 |
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1811644056305926144 |