A Meta-Analysis of Maternal Cured Meat Consumption during Pregnancy and the Risk of Childhood Brain Tumors
Objective: N-Nitroso compounds (NOCs) are recognized neural carcinogens in animal models and are suspected human carcinogens. A meta-analysis was performed examining the possible association of maternal intake of cured meat (an important source of dietary NOCs) during pregnancy and the risk of pedia...
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Online Access: | http://dx.doi.org/10.1159/000073979 https://www.karger.com/Article/Pdf/73979 |
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crskarger:10.1159/000073979 2024-06-16T07:40:27+00:00 A Meta-Analysis of Maternal Cured Meat Consumption during Pregnancy and the Risk of Childhood Brain Tumors Huncharek, Michael Kupelnick, Bruce 2004 http://dx.doi.org/10.1159/000073979 https://www.karger.com/Article/Pdf/73979 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses Neuroepidemiology volume 23, issue 1-2, page 78-84 ISSN 0251-5350 1423-0208 journal-article 2004 crskarger https://doi.org/10.1159/000073979 2024-05-22T13:00:31Z Objective: N-Nitroso compounds (NOCs) are recognized neural carcinogens in animal models and are suspected human carcinogens. A meta-analysis was performed examining the possible association of maternal intake of cured meat (an important source of dietary NOCs) during pregnancy and the risk of pediatric brain tumors. Methods: Data from epidemiological studies were pooled using a general variance-based meta-analytic method employing confidence intervals described by Greenland in 1986. The outcome of interest was a summary relative risk (RR) reflecting the risk of childhood brain tumor (CBT) development associated with maternal intake of cured meats during pregnancy. Sensitivity analyses were performed when necessary to explain any observed statistical heterogeneity. Results: Seven observational studies were found that met the protocol-specified inclusion criteria. Analysis for heterogeneity demonstrated a lack of statistical heterogeneity (p = 0.59), indicating that the data could be statistically combined. Pooling data from the 6 reports containing data on maternal cured meat intake of all types yielded an RR of 1.68 (1.30– 2.17), being a statistically significant result. Analyzing CBT risk by type of cured meat ingested showed that hot dog consumption increased CBT risk by 33% (1.08–1.66), with a similar increase shown by frequent ingestion of sausage, i.e. 44%. Conclusion: The data provide support for the suspected causal association between ingestion of NOCs from cured meats during pregnancy and subsequent CBT in offspring. Limitations in study design preclude definitive conclusions, but the relationship warrants exploration via additional observational and laboratory-based studies. Article in Journal/Newspaper Greenland Karger Greenland Neuroepidemiology 23 1-2 78 84 |
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Objective: N-Nitroso compounds (NOCs) are recognized neural carcinogens in animal models and are suspected human carcinogens. A meta-analysis was performed examining the possible association of maternal intake of cured meat (an important source of dietary NOCs) during pregnancy and the risk of pediatric brain tumors. Methods: Data from epidemiological studies were pooled using a general variance-based meta-analytic method employing confidence intervals described by Greenland in 1986. The outcome of interest was a summary relative risk (RR) reflecting the risk of childhood brain tumor (CBT) development associated with maternal intake of cured meats during pregnancy. Sensitivity analyses were performed when necessary to explain any observed statistical heterogeneity. Results: Seven observational studies were found that met the protocol-specified inclusion criteria. Analysis for heterogeneity demonstrated a lack of statistical heterogeneity (p = 0.59), indicating that the data could be statistically combined. Pooling data from the 6 reports containing data on maternal cured meat intake of all types yielded an RR of 1.68 (1.30– 2.17), being a statistically significant result. Analyzing CBT risk by type of cured meat ingested showed that hot dog consumption increased CBT risk by 33% (1.08–1.66), with a similar increase shown by frequent ingestion of sausage, i.e. 44%. Conclusion: The data provide support for the suspected causal association between ingestion of NOCs from cured meats during pregnancy and subsequent CBT in offspring. Limitations in study design preclude definitive conclusions, but the relationship warrants exploration via additional observational and laboratory-based studies. |
format |
Article in Journal/Newspaper |
author |
Huncharek, Michael Kupelnick, Bruce |
spellingShingle |
Huncharek, Michael Kupelnick, Bruce A Meta-Analysis of Maternal Cured Meat Consumption during Pregnancy and the Risk of Childhood Brain Tumors |
author_facet |
Huncharek, Michael Kupelnick, Bruce |
author_sort |
Huncharek, Michael |
title |
A Meta-Analysis of Maternal Cured Meat Consumption during Pregnancy and the Risk of Childhood Brain Tumors |
title_short |
A Meta-Analysis of Maternal Cured Meat Consumption during Pregnancy and the Risk of Childhood Brain Tumors |
title_full |
A Meta-Analysis of Maternal Cured Meat Consumption during Pregnancy and the Risk of Childhood Brain Tumors |
title_fullStr |
A Meta-Analysis of Maternal Cured Meat Consumption during Pregnancy and the Risk of Childhood Brain Tumors |
title_full_unstemmed |
A Meta-Analysis of Maternal Cured Meat Consumption during Pregnancy and the Risk of Childhood Brain Tumors |
title_sort |
meta-analysis of maternal cured meat consumption during pregnancy and the risk of childhood brain tumors |
publisher |
S. Karger AG |
publishDate |
2004 |
url |
http://dx.doi.org/10.1159/000073979 https://www.karger.com/Article/Pdf/73979 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Neuroepidemiology volume 23, issue 1-2, page 78-84 ISSN 0251-5350 1423-0208 |
op_rights |
https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses |
op_doi |
https://doi.org/10.1159/000073979 |
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Neuroepidemiology |
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23 |
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1-2 |
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78 |
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84 |
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1802007348596703232 |