Circulating Interleukin-1-Beta Levels after Acute and Prolonged Exposure to Low Temperatures: Human and Rat Studies
In this study we have investigated whether IL-1 acts as a mediator of stress responses elicited by exposure to low temperatures. We also sought whether IL-1 is released from the adrenal gland under basal conditions or after exposure to low temperatures. Normal and adrenalectomized (ADX) rats were us...
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Online Access: | http://dx.doi.org/10.1159/000026436 https://www.karger.com/Article/Pdf/26436 |
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crskarger:10.1159/000026436 2024-06-16T07:34:45+00:00 Circulating Interleukin-1-Beta Levels after Acute and Prolonged Exposure to Low Temperatures: Human and Rat Studies Tringali, Giuseppe Farrace, Stefano Ragazzoni, Enzo Dello Russo, Cinzia Piscitelli, Roberta Preziosi, Paolo Navarra, Pierluigi 2000 http://dx.doi.org/10.1159/000026436 https://www.karger.com/Article/Pdf/26436 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses Neuroimmunomodulation volume 7, issue 4, page 177-181 ISSN 1021-7401 1423-0216 journal-article 2000 crskarger https://doi.org/10.1159/000026436 2024-05-22T13:00:44Z In this study we have investigated whether IL-1 acts as a mediator of stress responses elicited by exposure to low temperatures. We also sought whether IL-1 is released from the adrenal gland under basal conditions or after exposure to low temperatures. Normal and adrenalectomized (ADX) rats were used for acute studies, whereas the effects of a prolonged exposure were investigated in a group of human subjects during a 45-day stay in Antarctica. Circulating levels of interleukin-1β (IL-1β) were taken as a marker of systemic IL-1 production both in humans and rats. In the latter, serum corticosterone (Cort) was also estimated. In intact rats, exposure to low temperatures (–25 or –35°C) for 30 or 90 min did not modify circulating IL-1β levels with respect to controls taken at +20°C. Adrenalectomy was associated with an increase in cytokine levels only in the group exposed to –35°C for 90 min; such increase is statistically significant compared to all groups of normal rats, whatever the experimental condition, as well as to ADX rats exposed to +20°C and –25°C for 30 and 90 min. In normal rats, the increase in circulating Cort levels was already maximal after exposure to –25°C for 30 min. In humans, circulating IL-1β levels after 45 days in Antarctica were significantly lower than those measured on arrival in the same subjects. Thus, no change in circulating IL-1β was associated with acute low-temperature stress in rats, whereas a marked decrease in serum cytokine was observed in humans after prolonged exposure to a cold environment. Experiments with ADX rats indicated that the contribution of the adrenal glands to total-body IL-1β production is negligible or absent. Article in Journal/Newspaper Antarc* Antarctica Karger Neuroimmunomodulation 7 4 177 181 |
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English |
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In this study we have investigated whether IL-1 acts as a mediator of stress responses elicited by exposure to low temperatures. We also sought whether IL-1 is released from the adrenal gland under basal conditions or after exposure to low temperatures. Normal and adrenalectomized (ADX) rats were used for acute studies, whereas the effects of a prolonged exposure were investigated in a group of human subjects during a 45-day stay in Antarctica. Circulating levels of interleukin-1β (IL-1β) were taken as a marker of systemic IL-1 production both in humans and rats. In the latter, serum corticosterone (Cort) was also estimated. In intact rats, exposure to low temperatures (–25 or –35°C) for 30 or 90 min did not modify circulating IL-1β levels with respect to controls taken at +20°C. Adrenalectomy was associated with an increase in cytokine levels only in the group exposed to –35°C for 90 min; such increase is statistically significant compared to all groups of normal rats, whatever the experimental condition, as well as to ADX rats exposed to +20°C and –25°C for 30 and 90 min. In normal rats, the increase in circulating Cort levels was already maximal after exposure to –25°C for 30 min. In humans, circulating IL-1β levels after 45 days in Antarctica were significantly lower than those measured on arrival in the same subjects. Thus, no change in circulating IL-1β was associated with acute low-temperature stress in rats, whereas a marked decrease in serum cytokine was observed in humans after prolonged exposure to a cold environment. Experiments with ADX rats indicated that the contribution of the adrenal glands to total-body IL-1β production is negligible or absent. |
format |
Article in Journal/Newspaper |
author |
Tringali, Giuseppe Farrace, Stefano Ragazzoni, Enzo Dello Russo, Cinzia Piscitelli, Roberta Preziosi, Paolo Navarra, Pierluigi |
spellingShingle |
Tringali, Giuseppe Farrace, Stefano Ragazzoni, Enzo Dello Russo, Cinzia Piscitelli, Roberta Preziosi, Paolo Navarra, Pierluigi Circulating Interleukin-1-Beta Levels after Acute and Prolonged Exposure to Low Temperatures: Human and Rat Studies |
author_facet |
Tringali, Giuseppe Farrace, Stefano Ragazzoni, Enzo Dello Russo, Cinzia Piscitelli, Roberta Preziosi, Paolo Navarra, Pierluigi |
author_sort |
Tringali, Giuseppe |
title |
Circulating Interleukin-1-Beta Levels after Acute and Prolonged Exposure to Low Temperatures: Human and Rat Studies |
title_short |
Circulating Interleukin-1-Beta Levels after Acute and Prolonged Exposure to Low Temperatures: Human and Rat Studies |
title_full |
Circulating Interleukin-1-Beta Levels after Acute and Prolonged Exposure to Low Temperatures: Human and Rat Studies |
title_fullStr |
Circulating Interleukin-1-Beta Levels after Acute and Prolonged Exposure to Low Temperatures: Human and Rat Studies |
title_full_unstemmed |
Circulating Interleukin-1-Beta Levels after Acute and Prolonged Exposure to Low Temperatures: Human and Rat Studies |
title_sort |
circulating interleukin-1-beta levels after acute and prolonged exposure to low temperatures: human and rat studies |
publisher |
S. Karger AG |
publishDate |
2000 |
url |
http://dx.doi.org/10.1159/000026436 https://www.karger.com/Article/Pdf/26436 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Neuroimmunomodulation volume 7, issue 4, page 177-181 ISSN 1021-7401 1423-0216 |
op_rights |
https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses |
op_doi |
https://doi.org/10.1159/000026436 |
container_title |
Neuroimmunomodulation |
container_volume |
7 |
container_issue |
4 |
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177 |
op_container_end_page |
181 |
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1802010653214375936 |