Protective Effect of Transferrin C3 in Lung Cancer?
In a previous study of lung cancer patients and controls from the Stockholm area in central Sweden, we found a significantly decreased frequency of the transferrin (TF) variant C3 in small cell and squamous epithelial lung cancer but not in adenocarcinoma, suggesting a protective effect of TF C3 in...
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Language: | English |
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S. Karger AG
1999
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Online Access: | http://dx.doi.org/10.1159/000011987 https://www.karger.com/Article/Pdf/11987 |
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crskarger:10.1159/000011987 2024-10-13T14:09:47+00:00 Protective Effect of Transferrin C3 in Lung Cancer? Beckman, L.E. van Landeghem, G.F. Sikström, C. Lundgren, R. Beckman, L. 1999 http://dx.doi.org/10.1159/000011987 https://www.karger.com/Article/Pdf/11987 en eng S. Karger AG https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses Oncology volume 56, issue 4, page 328-331 ISSN 0030-2414 1423-0232 journal-article 1999 crskarger https://doi.org/10.1159/000011987 2024-09-18T04:06:57Z In a previous study of lung cancer patients and controls from the Stockholm area in central Sweden, we found a significantly decreased frequency of the transferrin (TF) variant C3 in small cell and squamous epithelial lung cancer but not in adenocarcinoma, suggesting a protective effect of TF C3 in small cell and squamous lung cancer. In an attempt to replicate this association we studied TF types in lung cancer patients and controls from two additional Swedish subpopulations, viz. northern Sweden and southwestern Sweden. We were able to confirm the significantly decreased frequency of TF C3, especially in small cell lung cancer, in northern Sweden but not in southwestern Sweden. Thus the eventual protective effect of TF C3 in small cell lung cancer is an open question. We hypothesize that the association between TF C alleles and lung cancer may be secondary and dependent on linkage disequilibrium with allelic variants of newly discovered tumor-associated genes known to map to the same position (3q21) as TF, e.g. NCK and H-RYK. Article in Journal/Newspaper Northern Sweden Karger Oncology 56 4 328 331 |
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English |
description |
In a previous study of lung cancer patients and controls from the Stockholm area in central Sweden, we found a significantly decreased frequency of the transferrin (TF) variant C3 in small cell and squamous epithelial lung cancer but not in adenocarcinoma, suggesting a protective effect of TF C3 in small cell and squamous lung cancer. In an attempt to replicate this association we studied TF types in lung cancer patients and controls from two additional Swedish subpopulations, viz. northern Sweden and southwestern Sweden. We were able to confirm the significantly decreased frequency of TF C3, especially in small cell lung cancer, in northern Sweden but not in southwestern Sweden. Thus the eventual protective effect of TF C3 in small cell lung cancer is an open question. We hypothesize that the association between TF C alleles and lung cancer may be secondary and dependent on linkage disequilibrium with allelic variants of newly discovered tumor-associated genes known to map to the same position (3q21) as TF, e.g. NCK and H-RYK. |
format |
Article in Journal/Newspaper |
author |
Beckman, L.E. van Landeghem, G.F. Sikström, C. Lundgren, R. Beckman, L. |
spellingShingle |
Beckman, L.E. van Landeghem, G.F. Sikström, C. Lundgren, R. Beckman, L. Protective Effect of Transferrin C3 in Lung Cancer? |
author_facet |
Beckman, L.E. van Landeghem, G.F. Sikström, C. Lundgren, R. Beckman, L. |
author_sort |
Beckman, L.E. |
title |
Protective Effect of Transferrin C3 in Lung Cancer? |
title_short |
Protective Effect of Transferrin C3 in Lung Cancer? |
title_full |
Protective Effect of Transferrin C3 in Lung Cancer? |
title_fullStr |
Protective Effect of Transferrin C3 in Lung Cancer? |
title_full_unstemmed |
Protective Effect of Transferrin C3 in Lung Cancer? |
title_sort |
protective effect of transferrin c3 in lung cancer? |
publisher |
S. Karger AG |
publishDate |
1999 |
url |
http://dx.doi.org/10.1159/000011987 https://www.karger.com/Article/Pdf/11987 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Oncology volume 56, issue 4, page 328-331 ISSN 0030-2414 1423-0232 |
op_rights |
https://www.karger.com/Services/SiteLicenses https://www.karger.com/Services/SiteLicenses |
op_doi |
https://doi.org/10.1159/000011987 |
container_title |
Oncology |
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56 |
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4 |
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328 |
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331 |
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1812816848426631168 |