Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis
A total of 1,263 adults from Newfoundland and Labrador were studied in the research. Body mass index (BMI) and percent trunk fat (PTF) were analyzed as biomarkers for obesity. The Mendelian randomization (MR) approach with two single-nucleotide polymorphisms in the fat-mass and obesity (FTO) gene as...
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crsagepubl:10.4137/geg.s38289 2024-06-23T07:54:44+00:00 Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis Barning, Frank Abarin, Taraneh 2016 http://dx.doi.org/10.4137/geg.s38289 http://journals.sagepub.com/doi/pdf/10.4137/GEG.S38289 http://journals.sagepub.com/doi/full-xml/10.4137/GEG.S38289 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Genetics & Epigenetics volume 8, page GEG.S38289 ISSN 1179-237X 1179-237X journal-article 2016 crsagepubl https://doi.org/10.4137/geg.s38289 2024-06-11T04:32:15Z A total of 1,263 adults from Newfoundland and Labrador were studied in the research. Body mass index (BMI) and percent trunk fat (PTF) were analyzed as biomarkers for obesity. The Mendelian randomization (MR) approach with two single-nucleotide polymorphisms in the fat-mass and obesity (FTO) gene as instruments was employed to assess the causal effect. In both genders, increasing physical activity significantly reduced BMI and PTF when adjusted for age and the FTO gene. The effect of physical activity was stronger on PTF than BMI. Direct observational analyses showed significant increase in BMI/PTF when physical activity decreased. A similar association in MR analyses was not significant. The association between physical activity and BMI/PTF could be due to reversed causality or common confounding factors. Our study provides insights into the causal contributions of obesity to physical activity in adults. Health intervention strategies to increase physical activity among adults should include some other plans such as improving diet for reducing obesity. Article in Journal/Newspaper Newfoundland SAGE Publications Newfoundland Genetics & Epigenetics 8 GEG.S38289 |
institution |
Open Polar |
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SAGE Publications |
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crsagepubl |
language |
English |
description |
A total of 1,263 adults from Newfoundland and Labrador were studied in the research. Body mass index (BMI) and percent trunk fat (PTF) were analyzed as biomarkers for obesity. The Mendelian randomization (MR) approach with two single-nucleotide polymorphisms in the fat-mass and obesity (FTO) gene as instruments was employed to assess the causal effect. In both genders, increasing physical activity significantly reduced BMI and PTF when adjusted for age and the FTO gene. The effect of physical activity was stronger on PTF than BMI. Direct observational analyses showed significant increase in BMI/PTF when physical activity decreased. A similar association in MR analyses was not significant. The association between physical activity and BMI/PTF could be due to reversed causality or common confounding factors. Our study provides insights into the causal contributions of obesity to physical activity in adults. Health intervention strategies to increase physical activity among adults should include some other plans such as improving diet for reducing obesity. |
format |
Article in Journal/Newspaper |
author |
Barning, Frank Abarin, Taraneh |
spellingShingle |
Barning, Frank Abarin, Taraneh Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis |
author_facet |
Barning, Frank Abarin, Taraneh |
author_sort |
Barning, Frank |
title |
Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis |
title_short |
Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis |
title_full |
Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis |
title_fullStr |
Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis |
title_full_unstemmed |
Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis |
title_sort |
assessing the causality factors in the association between (abdominal) obesity and physical activity among the newfoundland population–-a mendelian randomization analysis |
publisher |
SAGE Publications |
publishDate |
2016 |
url |
http://dx.doi.org/10.4137/geg.s38289 http://journals.sagepub.com/doi/pdf/10.4137/GEG.S38289 http://journals.sagepub.com/doi/full-xml/10.4137/GEG.S38289 |
geographic |
Newfoundland |
geographic_facet |
Newfoundland |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Genetics & Epigenetics volume 8, page GEG.S38289 ISSN 1179-237X 1179-237X |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.4137/geg.s38289 |
container_title |
Genetics & Epigenetics |
container_volume |
8 |
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GEG.S38289 |
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1802646992451534848 |