Long-Term Prognosis and Comorbidities Associated with Psoriasis in the Newfoundland and Labrador Founder Population

• Published in: Journal of Cutaneous Medicine and Surgery
• Main Authors: Gulliver, Wayne P., MacDonald, Don, Gladney, Neil, Alaghehbandan, Reza, Rahman, Proton, Baker, K. Adam
• Format: Article in Journal/Newspaper
• Language: English
• Published: SAGE Publications 2011
• Subjects: Newfoundland
• Online Access: http://dx.doi.org/10.2310/7750.2010.10013; https://journals.sagepub.com/doi/pdf/10.2310/7750.2010.10013; https://journals.sagepub.com/doi/full-xml/10.2310/7750.2010.10013

Background: Psoriasis is a common chronic immune-mediated inflammatory disorder of the skin with several associated comorbidities. Objective: To assess the prevalence of comorbidities in a cohort of psoriasis patients within the Canadian province of Newfoundland and Labrador (NL). Methods: This cross-sectional observational study investigated hospital-coded comorbidities associated with psoriasis in comparison to the general NL hospitalized population. Results: Patients died significantly younger than the general population, with patients having an earlier disease onset (≤ 25 years) dying at a younger age than those with a later onset (> 25 years; 59.3 vs 71.2; p = .001). Patients were hospitalized more frequently for several system disorders than the general population, and a potential association was observed between prognostic factors such as age at onset, disease severity, and HLA-Cw6 genotype and certain comorbid conditions. Conclusion: This study supports an association between psoriasis and other conditions, such as circulatory and endocrine diseases.