West Nile Flavivirus Polioencephalomyelitis in a Harbor Seal ( Phoca vitulina)
A 12-year-old male harbor seal presented with progressive signs of neurologic dysfunction including head tremors, muzzle twitching, clonic spasms, and weakness. Lesions included polioenceph-alomyelitis with glial nodules, spheroids, neuronophagia, ring hemorrhages, and a few neutrophils. Neurons, fi...
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crsagepubl:10.1354/vp.43-1-58 2024-10-06T13:49:17+00:00 West Nile Flavivirus Polioencephalomyelitis in a Harbor Seal ( Phoca vitulina) Piero, F. Del Stremme, D. W. Habecker, P. L. Cantile, C. 2006 http://dx.doi.org/10.1354/vp.43-1-58 https://journals.sagepub.com/doi/pdf/10.1354/vp.43-1-58 https://journals.sagepub.com/doi/full-xml/10.1354/vp.43-1-58 en eng SAGE Publications https://journals.sagepub.com/page/policies/text-and-data-mining-license Veterinary Pathology volume 43, issue 1, page 58-61 ISSN 0300-9858 1544-2217 journal-article 2006 crsagepubl https://doi.org/10.1354/vp.43-1-58 2024-09-10T04:27:41Z A 12-year-old male harbor seal presented with progressive signs of neurologic dysfunction including head tremors, muzzle twitching, clonic spasms, and weakness. Lesions included polioenceph-alomyelitis with glial nodules, spheroids, neuronophagia, ring hemorrhages, and a few neutrophils. Neurons, fibers, and glial nodules were multifocally colonized with intracytoplasmic West Nile flavivirus antigens that were demonstrated using indirect immunohistochemical analysis. Flavivirus on cultured cells also was isolated and was identified by use of monoclonal antibodies and reverse transcriptase-polymerase chain reaction analysis. Clinical signs of disease and lesion morphology and distribution were similar to those of equine West Nile virus infection. Similar to horses, alpacas, humans, dogs, and reptiles, seals can be dead-end hosts of West Nile virus. Article in Journal/Newspaper harbor seal Phoca vitulina SAGE Publications Veterinary Pathology 43 1 58 61 |
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SAGE Publications |
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crsagepubl |
language |
English |
description |
A 12-year-old male harbor seal presented with progressive signs of neurologic dysfunction including head tremors, muzzle twitching, clonic spasms, and weakness. Lesions included polioenceph-alomyelitis with glial nodules, spheroids, neuronophagia, ring hemorrhages, and a few neutrophils. Neurons, fibers, and glial nodules were multifocally colonized with intracytoplasmic West Nile flavivirus antigens that were demonstrated using indirect immunohistochemical analysis. Flavivirus on cultured cells also was isolated and was identified by use of monoclonal antibodies and reverse transcriptase-polymerase chain reaction analysis. Clinical signs of disease and lesion morphology and distribution were similar to those of equine West Nile virus infection. Similar to horses, alpacas, humans, dogs, and reptiles, seals can be dead-end hosts of West Nile virus. |
format |
Article in Journal/Newspaper |
author |
Piero, F. Del Stremme, D. W. Habecker, P. L. Cantile, C. |
spellingShingle |
Piero, F. Del Stremme, D. W. Habecker, P. L. Cantile, C. West Nile Flavivirus Polioencephalomyelitis in a Harbor Seal ( Phoca vitulina) |
author_facet |
Piero, F. Del Stremme, D. W. Habecker, P. L. Cantile, C. |
author_sort |
Piero, F. Del |
title |
West Nile Flavivirus Polioencephalomyelitis in a Harbor Seal ( Phoca vitulina) |
title_short |
West Nile Flavivirus Polioencephalomyelitis in a Harbor Seal ( Phoca vitulina) |
title_full |
West Nile Flavivirus Polioencephalomyelitis in a Harbor Seal ( Phoca vitulina) |
title_fullStr |
West Nile Flavivirus Polioencephalomyelitis in a Harbor Seal ( Phoca vitulina) |
title_full_unstemmed |
West Nile Flavivirus Polioencephalomyelitis in a Harbor Seal ( Phoca vitulina) |
title_sort |
west nile flavivirus polioencephalomyelitis in a harbor seal ( phoca vitulina) |
publisher |
SAGE Publications |
publishDate |
2006 |
url |
http://dx.doi.org/10.1354/vp.43-1-58 https://journals.sagepub.com/doi/pdf/10.1354/vp.43-1-58 https://journals.sagepub.com/doi/full-xml/10.1354/vp.43-1-58 |
genre |
harbor seal Phoca vitulina |
genre_facet |
harbor seal Phoca vitulina |
op_source |
Veterinary Pathology volume 43, issue 1, page 58-61 ISSN 0300-9858 1544-2217 |
op_rights |
https://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1354/vp.43-1-58 |
container_title |
Veterinary Pathology |
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43 |
container_issue |
1 |
container_start_page |
58 |
op_container_end_page |
61 |
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1812177358867660800 |