Immunohistochemical Evaluation of a Malignant Pheochromocytoma in a Wolfdog

• Published in: Veterinary Pathology
• Main Authors: Sako, T., Kitamura, N., Kagawa, Y., Hirayama, K., Morita, M., Kurosawa, T., Yoshino, T., Taniyama, H.
• Format: Article in Journal/Newspaper
• Language: English
• Published: SAGE Publications 2001
• Subjects: Canis lupus
• Online Access: http://dx.doi.org/10.1354/vp.38-4-447; https://journals.sagepub.com/doi/pdf/10.1354/vp.38-4-447; https://journals.sagepub.com/doi/full-xml/10.1354/vp.38-4-447

A malignant pheochromocytoma with multiple metastases was diagnosed in a 7-year-old male wolfdog that resulted from a cross between an eastern timber wolf (Canis lupus lycaon) and an Alaskan malamute. A yellowish white neoplastic mass approximately 10 cm diameter was found in the right adrenal gland. The neoplasm penetrated through the wall of the caudal vena cava. A diagnosis of pheochromocytoma was established by histopathologic and immunohistochemical procedures. Immunohistochemically, the neoplastic cells expressed chromogranin A, substance P, synaptophysin, Leu-7, protein gene product 9.5, methionine- enkephalin, S100 protein, and galanin. Multiple metastatic tumors were found in the kidneys, spleen, lungs, heart, and liver.