Thymic Cystic Degeneration, Pseudoepitheliomatous Hyperplasia, and Hemorrhage in a Dog with Brodifacoum Toxicosis
Thymic cysts with pseudoepitheliomatous hyperplasia are described in a 7-month-old female American Eskimo Dog that died of complications from brodifacoum poisoning. Grossly, there was hemothorax with marked cranial mediastinal hemorrhage. Histologically, thymic lobules were expanded and distorted by...
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crsagepubl:10.1354/vp.08-vp-0193-r-bc 2023-05-15T16:07:43+02:00 Thymic Cystic Degeneration, Pseudoepitheliomatous Hyperplasia, and Hemorrhage in a Dog with Brodifacoum Toxicosis Rickman, B. H. Gurfield, N. 2009 http://dx.doi.org/10.1354/vp.08-vp-0193-r-bc http://journals.sagepub.com/doi/pdf/10.1354/vp.08-VP-0193-R-BC http://journals.sagepub.com/doi/full-xml/10.1354/vp.08-VP-0193-R-BC en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Veterinary Pathology volume 46, issue 3, page 449-452 ISSN 0300-9858 1544-2217 General Veterinary journal-article 2009 crsagepubl https://doi.org/10.1354/vp.08-vp-0193-r-bc 2022-07-03T16:06:24Z Thymic cysts with pseudoepitheliomatous hyperplasia are described in a 7-month-old female American Eskimo Dog that died of complications from brodifacoum poisoning. Grossly, there was hemothorax with marked cranial mediastinal hemorrhage. Histologically, thymic lobules were expanded and distorted by irregular cysts, lined by single to multiple layers of plump to slightly attenuated polygonal squamous epithelial cells supported by a basement membrane (pseudoepitheliomatous hyperplasia). The thymus had a paucity of lymphocytes and lacked corticomedullary differentiation. Extensive hemorrhage within the cysts and thymic parenchyma extended into the adjacent adipose tissue. To the authors' knowledge, this is the first report of cystic thymic degeneration with pseudoepitheliomatous hyperplasia in a nonhuman species. Article in Journal/Newspaper eskimo* SAGE Publications (via Crossref) Veterinary Pathology 46 3 449 452 |
institution |
Open Polar |
collection |
SAGE Publications (via Crossref) |
op_collection_id |
crsagepubl |
language |
English |
topic |
General Veterinary |
spellingShingle |
General Veterinary Rickman, B. H. Gurfield, N. Thymic Cystic Degeneration, Pseudoepitheliomatous Hyperplasia, and Hemorrhage in a Dog with Brodifacoum Toxicosis |
topic_facet |
General Veterinary |
description |
Thymic cysts with pseudoepitheliomatous hyperplasia are described in a 7-month-old female American Eskimo Dog that died of complications from brodifacoum poisoning. Grossly, there was hemothorax with marked cranial mediastinal hemorrhage. Histologically, thymic lobules were expanded and distorted by irregular cysts, lined by single to multiple layers of plump to slightly attenuated polygonal squamous epithelial cells supported by a basement membrane (pseudoepitheliomatous hyperplasia). The thymus had a paucity of lymphocytes and lacked corticomedullary differentiation. Extensive hemorrhage within the cysts and thymic parenchyma extended into the adjacent adipose tissue. To the authors' knowledge, this is the first report of cystic thymic degeneration with pseudoepitheliomatous hyperplasia in a nonhuman species. |
format |
Article in Journal/Newspaper |
author |
Rickman, B. H. Gurfield, N. |
author_facet |
Rickman, B. H. Gurfield, N. |
author_sort |
Rickman, B. H. |
title |
Thymic Cystic Degeneration, Pseudoepitheliomatous Hyperplasia, and Hemorrhage in a Dog with Brodifacoum Toxicosis |
title_short |
Thymic Cystic Degeneration, Pseudoepitheliomatous Hyperplasia, and Hemorrhage in a Dog with Brodifacoum Toxicosis |
title_full |
Thymic Cystic Degeneration, Pseudoepitheliomatous Hyperplasia, and Hemorrhage in a Dog with Brodifacoum Toxicosis |
title_fullStr |
Thymic Cystic Degeneration, Pseudoepitheliomatous Hyperplasia, and Hemorrhage in a Dog with Brodifacoum Toxicosis |
title_full_unstemmed |
Thymic Cystic Degeneration, Pseudoepitheliomatous Hyperplasia, and Hemorrhage in a Dog with Brodifacoum Toxicosis |
title_sort |
thymic cystic degeneration, pseudoepitheliomatous hyperplasia, and hemorrhage in a dog with brodifacoum toxicosis |
publisher |
SAGE Publications |
publishDate |
2009 |
url |
http://dx.doi.org/10.1354/vp.08-vp-0193-r-bc http://journals.sagepub.com/doi/pdf/10.1354/vp.08-VP-0193-R-BC http://journals.sagepub.com/doi/full-xml/10.1354/vp.08-VP-0193-R-BC |
genre |
eskimo* |
genre_facet |
eskimo* |
op_source |
Veterinary Pathology volume 46, issue 3, page 449-452 ISSN 0300-9858 1544-2217 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1354/vp.08-vp-0193-r-bc |
container_title |
Veterinary Pathology |
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46 |
container_issue |
3 |
container_start_page |
449 |
op_container_end_page |
452 |
_version_ |
1766403802919862272 |