Evidence for the Cardioprotective Effects of Omega-3 Fatty Acids
OBJECTIVE: To review available literature regarding the cardiovascular effects of marine-derived ω-3 fatty acids and evaluate the benefit of these fatty acids in the prevention of coronary heart disease. DATA SOURCES: Biomedical literature accessed through a MEDLINE search (1966–April 2002). Search...
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crsagepubl:10.1345/aph.1a314 2024-03-03T08:44:07+00:00 Evidence for the Cardioprotective Effects of Omega-3 Fatty Acids Carroll, Douglas N Roth, Mary T 2002 http://dx.doi.org/10.1345/aph.1a314 http://journals.sagepub.com/doi/pdf/10.1345/aph.1A314 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Annals of Pharmacotherapy volume 36, issue 12, page 1950-1956 ISSN 1060-0280 1542-6270 Pharmacology (medical) journal-article 2002 crsagepubl https://doi.org/10.1345/aph.1a314 2024-02-05T10:37:18Z OBJECTIVE: To review available literature regarding the cardiovascular effects of marine-derived ω-3 fatty acids and evaluate the benefit of these fatty acids in the prevention of coronary heart disease. DATA SOURCES: Biomedical literature accessed through a MEDLINE search (1966–April 2002). Search terms included fish oil, omega-3 fatty acid, sudden death, hypertriglyceridemia, myocardial infarction, and mortality. DATA SYNTHESIS: Following an early 1970's observational investigation that ω-3 fatty acids may reduce the occurrence of myocardial infarction—related deaths in Greenland Eskimos, additional trials have been conducted that support this finding. Epidemiologic and clinical trial data suggest that ω-3 fatty acids may reduce the risk of cardiovascular-related death by 29–52%. In addition, the risk of sudden cardiac death was found to be reduced by 45–81%. Possible mechanisms for these beneficial effects include antiarrhythmic properties, improved endothelial function, antiinflammatory action, and reductions in serum triglyceride concentrations. ω-3 Fatty acids are fairly well tolerated; potential adverse effects include bloating and gastrointestinal distress, “fishy taste” in the mouth, hyperglycemia, increased risk of bleeding, and a slight increase in low-density-lipoprotein cholesterol. CONCLUSIONS: ω-3 Fatty acids may be beneficial and should be considered in patients with documented coronary heart disease. They may be particularly beneficial for patients with risk factors for sudden cardiac death. Article in Journal/Newspaper eskimo* Greenland SAGE Publications Greenland Annals of Pharmacotherapy 36 12 1950 1956 |
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English |
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Pharmacology (medical) |
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Pharmacology (medical) Carroll, Douglas N Roth, Mary T Evidence for the Cardioprotective Effects of Omega-3 Fatty Acids |
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Pharmacology (medical) |
description |
OBJECTIVE: To review available literature regarding the cardiovascular effects of marine-derived ω-3 fatty acids and evaluate the benefit of these fatty acids in the prevention of coronary heart disease. DATA SOURCES: Biomedical literature accessed through a MEDLINE search (1966–April 2002). Search terms included fish oil, omega-3 fatty acid, sudden death, hypertriglyceridemia, myocardial infarction, and mortality. DATA SYNTHESIS: Following an early 1970's observational investigation that ω-3 fatty acids may reduce the occurrence of myocardial infarction—related deaths in Greenland Eskimos, additional trials have been conducted that support this finding. Epidemiologic and clinical trial data suggest that ω-3 fatty acids may reduce the risk of cardiovascular-related death by 29–52%. In addition, the risk of sudden cardiac death was found to be reduced by 45–81%. Possible mechanisms for these beneficial effects include antiarrhythmic properties, improved endothelial function, antiinflammatory action, and reductions in serum triglyceride concentrations. ω-3 Fatty acids are fairly well tolerated; potential adverse effects include bloating and gastrointestinal distress, “fishy taste” in the mouth, hyperglycemia, increased risk of bleeding, and a slight increase in low-density-lipoprotein cholesterol. CONCLUSIONS: ω-3 Fatty acids may be beneficial and should be considered in patients with documented coronary heart disease. They may be particularly beneficial for patients with risk factors for sudden cardiac death. |
format |
Article in Journal/Newspaper |
author |
Carroll, Douglas N Roth, Mary T |
author_facet |
Carroll, Douglas N Roth, Mary T |
author_sort |
Carroll, Douglas N |
title |
Evidence for the Cardioprotective Effects of Omega-3 Fatty Acids |
title_short |
Evidence for the Cardioprotective Effects of Omega-3 Fatty Acids |
title_full |
Evidence for the Cardioprotective Effects of Omega-3 Fatty Acids |
title_fullStr |
Evidence for the Cardioprotective Effects of Omega-3 Fatty Acids |
title_full_unstemmed |
Evidence for the Cardioprotective Effects of Omega-3 Fatty Acids |
title_sort |
evidence for the cardioprotective effects of omega-3 fatty acids |
publisher |
SAGE Publications |
publishDate |
2002 |
url |
http://dx.doi.org/10.1345/aph.1a314 http://journals.sagepub.com/doi/pdf/10.1345/aph.1A314 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland |
genre_facet |
eskimo* Greenland |
op_source |
Annals of Pharmacotherapy volume 36, issue 12, page 1950-1956 ISSN 1060-0280 1542-6270 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1345/aph.1a314 |
container_title |
Annals of Pharmacotherapy |
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36 |
container_issue |
12 |
container_start_page |
1950 |
op_container_end_page |
1956 |
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1792499596554928128 |