The relation between menarche and the age of first symptoms in a multiple sclerosis cohort
Background Previously, multiple sclerosis (MS) has been thought to be associated with changes in hormone levels. This study investigates the association between the age of menarche and the age of onset of the first symptoms of MS. Methods A complete list of patients diagnosed with MS in the province...
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crsagepubl:10.1191/135248506ms1267oa 2024-06-23T07:54:46+00:00 The relation between menarche and the age of first symptoms in a multiple sclerosis cohort Sloka, J S Pryse-Phillips, W EM Stefanelli, M 2006 http://dx.doi.org/10.1191/135248506ms1267oa http://journals.sagepub.com/doi/pdf/10.1191/135248506ms1267oa en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Multiple Sclerosis Journal volume 12, issue 3, page 333-339 ISSN 1352-4585 1477-0970 journal-article 2006 crsagepubl https://doi.org/10.1191/135248506ms1267oa 2024-06-04T06:28:53Z Background Previously, multiple sclerosis (MS) has been thought to be associated with changes in hormone levels. This study investigates the association between the age of menarche and the age of onset of the first symptoms of MS. Methods A complete list of patients diagnosed with MS in the province of Newfoundland and Labrador was constructed. The age of menarche for our entire relapsing remitting female MS (RRMS) population was requested by mailout survey. Age of symptom onset was ascertained by chart review. Results A 74% rate of return on the survey results was obtained (150 RRMS patients). A linear regression model demonstrated that the age of first symptoms increased by 1.16 years as the age of menarche increased by one year (R 2 =0.69, P=0.04). Another analysis showed that the average age of first symptoms for women with reported menarche from 10 to 12 years was 28.96 years compared with 31.83 years for a reported menarche from 13 to 15 years, a significant difference ( P=0.047, t-test). Conclusions This study suggests that menarche may be related to the pathogenesis of MS. Article in Journal/Newspaper Newfoundland SAGE Publications Newfoundland Multiple Sclerosis Journal 12 3 333 339 |
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SAGE Publications |
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English |
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Background Previously, multiple sclerosis (MS) has been thought to be associated with changes in hormone levels. This study investigates the association between the age of menarche and the age of onset of the first symptoms of MS. Methods A complete list of patients diagnosed with MS in the province of Newfoundland and Labrador was constructed. The age of menarche for our entire relapsing remitting female MS (RRMS) population was requested by mailout survey. Age of symptom onset was ascertained by chart review. Results A 74% rate of return on the survey results was obtained (150 RRMS patients). A linear regression model demonstrated that the age of first symptoms increased by 1.16 years as the age of menarche increased by one year (R 2 =0.69, P=0.04). Another analysis showed that the average age of first symptoms for women with reported menarche from 10 to 12 years was 28.96 years compared with 31.83 years for a reported menarche from 13 to 15 years, a significant difference ( P=0.047, t-test). Conclusions This study suggests that menarche may be related to the pathogenesis of MS. |
format |
Article in Journal/Newspaper |
author |
Sloka, J S Pryse-Phillips, W EM Stefanelli, M |
spellingShingle |
Sloka, J S Pryse-Phillips, W EM Stefanelli, M The relation between menarche and the age of first symptoms in a multiple sclerosis cohort |
author_facet |
Sloka, J S Pryse-Phillips, W EM Stefanelli, M |
author_sort |
Sloka, J S |
title |
The relation between menarche and the age of first symptoms in a multiple sclerosis cohort |
title_short |
The relation between menarche and the age of first symptoms in a multiple sclerosis cohort |
title_full |
The relation between menarche and the age of first symptoms in a multiple sclerosis cohort |
title_fullStr |
The relation between menarche and the age of first symptoms in a multiple sclerosis cohort |
title_full_unstemmed |
The relation between menarche and the age of first symptoms in a multiple sclerosis cohort |
title_sort |
relation between menarche and the age of first symptoms in a multiple sclerosis cohort |
publisher |
SAGE Publications |
publishDate |
2006 |
url |
http://dx.doi.org/10.1191/135248506ms1267oa http://journals.sagepub.com/doi/pdf/10.1191/135248506ms1267oa |
geographic |
Newfoundland |
geographic_facet |
Newfoundland |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Multiple Sclerosis Journal volume 12, issue 3, page 333-339 ISSN 1352-4585 1477-0970 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1191/135248506ms1267oa |
container_title |
Multiple Sclerosis Journal |
container_volume |
12 |
container_issue |
3 |
container_start_page |
333 |
op_container_end_page |
339 |
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1802647041156841472 |