Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats
Carbendazim is a systemic broad-spectrum fungicide controlling a wide range of pathogens. It is also used as a preservative in paint, textile, papermaking and leather industry, as well as a preservative of fruits. In the present study, carbendazim was administered at 0, 150, 300 and 600 mg/kg per da...
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crsagepubl:10.1191/096032701718890603 2024-06-23T07:56:24+00:00 Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats Selmanoğlu, G Barlas, N Songür, S Koçskaya, E A 2001 http://dx.doi.org/10.1191/096032701718890603 http://journals.sagepub.com/doi/pdf/10.1191/096032701718890603 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Human & Experimental Toxicology volume 20, issue 12, page 625-630 ISSN 0960-3271 1477-0903 journal-article 2001 crsagepubl https://doi.org/10.1191/096032701718890603 2024-06-11T04:33:00Z Carbendazim is a systemic broad-spectrum fungicide controlling a wide range of pathogens. It is also used as a preservative in paint, textile, papermaking and leather industry, as well as a preservative of fruits. In the present study, carbendazim was administered at 0, 150, 300 and 600 mg/kg per day doses orally to male rats (Rattus rattus) for 15 weeks. At the end of the experiment, blood samples, liver and kidney tissues of each animal were taken. Serum enzyme activities, and haematological and biochemical parameters were analysed. In toxicological tests, 600 mg/kg per day doses of carbendazim caused an increase of albumin, glucose, creatinine and cholesterol levels. Also, at the same doses, white blood cell and lymphocyte counts decreased. However, mean cell hemoglobin and mean cell hemoglobin concentrations increased. Histopathological examinations revealed congestion, an enlargement of the sinusoids, an increase in the number of Kupffer cells, mononuclear cell infiltration and hydropic degeneration in the liver. At the highest doses, congestion, mononuclear cell infiltration, tubular degeneration and fibrosis were observed in the kidney tissue. These results indicate that 300 and 600 mg/kg per day carbendazim affected the liver and kidney tissue and caused some changes on haematological and biochemical parameters of rats. Article in Journal/Newspaper Rattus rattus SAGE Publications Human & Experimental Toxicology 20 12 625 630 |
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Carbendazim is a systemic broad-spectrum fungicide controlling a wide range of pathogens. It is also used as a preservative in paint, textile, papermaking and leather industry, as well as a preservative of fruits. In the present study, carbendazim was administered at 0, 150, 300 and 600 mg/kg per day doses orally to male rats (Rattus rattus) for 15 weeks. At the end of the experiment, blood samples, liver and kidney tissues of each animal were taken. Serum enzyme activities, and haematological and biochemical parameters were analysed. In toxicological tests, 600 mg/kg per day doses of carbendazim caused an increase of albumin, glucose, creatinine and cholesterol levels. Also, at the same doses, white blood cell and lymphocyte counts decreased. However, mean cell hemoglobin and mean cell hemoglobin concentrations increased. Histopathological examinations revealed congestion, an enlargement of the sinusoids, an increase in the number of Kupffer cells, mononuclear cell infiltration and hydropic degeneration in the liver. At the highest doses, congestion, mononuclear cell infiltration, tubular degeneration and fibrosis were observed in the kidney tissue. These results indicate that 300 and 600 mg/kg per day carbendazim affected the liver and kidney tissue and caused some changes on haematological and biochemical parameters of rats. |
format |
Article in Journal/Newspaper |
author |
Selmanoğlu, G Barlas, N Songür, S Koçskaya, E A |
spellingShingle |
Selmanoğlu, G Barlas, N Songür, S Koçskaya, E A Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
author_facet |
Selmanoğlu, G Barlas, N Songür, S Koçskaya, E A |
author_sort |
Selmanoğlu, G |
title |
Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
title_short |
Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
title_full |
Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
title_fullStr |
Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
title_full_unstemmed |
Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
title_sort |
carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
publisher |
SAGE Publications |
publishDate |
2001 |
url |
http://dx.doi.org/10.1191/096032701718890603 http://journals.sagepub.com/doi/pdf/10.1191/096032701718890603 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Human & Experimental Toxicology volume 20, issue 12, page 625-630 ISSN 0960-3271 1477-0903 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1191/096032701718890603 |
container_title |
Human & Experimental Toxicology |
container_volume |
20 |
container_issue |
12 |
container_start_page |
625 |
op_container_end_page |
630 |
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1802649460689338368 |