Lymphoepithelial carcinoma of the parotid gland

• Published in: SAGE Open Medical Case Reports
• Main Authors: Kallel, Souha, Ayadi, Sirine, Salem, Noura, Zghal, Mouna, Mariem, Ben Ayed, Ayedi, Lobna, Mnejja, Malek, Boudawara, Tahya, Charfeddine, Ilhem
• Format: Article in Journal/Newspaper
• Language: English
• Published: SAGE Publications 2024
• Subjects: inuit
• Online Access: http://dx.doi.org/10.1177/2050313x241260210; https://journals.sagepub.com/doi/pdf/10.1177/2050313X241260210; https://journals.sagepub.com/doi/full-xml/10.1177/2050313X241260210

Primary lymphoepithelial carcinoma of the salivary glands is an exceptional oncological condition that predominantly emerges within the parotid gland. A significant prevalence of lymphoepithelial carcinoma has been reported in the Inuit population, along with an associated positive serology for Epstein-Barr virus in these endemic regions. In this paper, we present a case of primary lymphoepithelial carcinoma of the parotid gland in a 68-year-old female patient with a history of diabetes and hypertension residing in a non-endemic area. Histology plays a critical role in the definitive diagnosis, and confirming the primary origin of lymphoepithelial carcinoma after ruling out metastasis from undifferentiated nasopharyngeal carcinoma. The mainstay of treatment is a combination of surgical resection and adjuvant radiotherapy. Inoperable forms are typically managed with chemoradiotherapy.