Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons
Natural products and their derivatives have served as powerful therapeutics against pathogenic microorganisms and are the mainstay of our currently available treatment options to combat infections. As part of our ongoing search for antimicrobial natural products from marine organisms, one fraction p...
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Online Access: | http://dx.doi.org/10.1177/1934578x21996180 http://journals.sagepub.com/doi/pdf/10.1177/1934578X21996180 http://journals.sagepub.com/doi/full-xml/10.1177/1934578X21996180 |
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crsagepubl:10.1177/1934578x21996180 2024-09-09T19:24:20+00:00 Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons Hansen, Kine Ø. Hansen, Ida K. Ø. Richard, Céline S. Jenssen, Marte Andersen, Jeanette H. Hansen, Espen H. 2021 http://dx.doi.org/10.1177/1934578x21996180 http://journals.sagepub.com/doi/pdf/10.1177/1934578X21996180 http://journals.sagepub.com/doi/full-xml/10.1177/1934578X21996180 en eng SAGE Publications https://creativecommons.org/licenses/by/4.0/ Natural Product Communications volume 16, issue 2, page 1934578X2199618 ISSN 1934-578X 1555-9475 journal-article 2021 crsagepubl https://doi.org/10.1177/1934578x21996180 2024-07-29T04:24:19Z Natural products and their derivatives have served as powerful therapeutics against pathogenic microorganisms and are the mainstay of our currently available treatment options to combat infections. As part of our ongoing search for antimicrobial natural products from marine organisms, one fraction prepared from the Arctic marine bryozoan Securiflustra securifrons was found to be active against the human pathogenic bacterium Streptococcus agalactiae (gr. B). Chemical investigation of the fraction revealed that it contained several variants of the highly modified secondary metabolites known as securamines. The securamines are alkaloids sharing a common isoprene-histamine-tryptamine backbone. In this study, we describe the antimicrobial activities of securamine C, E, and H – J (4, 5, and 1-3) and the attempt to deconvolute the mode of action of 1. Article in Journal/Newspaper Arctic SAGE Publications Arctic Natural Product Communications 16 2 1934578X2199618 |
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Open Polar |
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SAGE Publications |
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crsagepubl |
language |
English |
description |
Natural products and their derivatives have served as powerful therapeutics against pathogenic microorganisms and are the mainstay of our currently available treatment options to combat infections. As part of our ongoing search for antimicrobial natural products from marine organisms, one fraction prepared from the Arctic marine bryozoan Securiflustra securifrons was found to be active against the human pathogenic bacterium Streptococcus agalactiae (gr. B). Chemical investigation of the fraction revealed that it contained several variants of the highly modified secondary metabolites known as securamines. The securamines are alkaloids sharing a common isoprene-histamine-tryptamine backbone. In this study, we describe the antimicrobial activities of securamine C, E, and H – J (4, 5, and 1-3) and the attempt to deconvolute the mode of action of 1. |
format |
Article in Journal/Newspaper |
author |
Hansen, Kine Ø. Hansen, Ida K. Ø. Richard, Céline S. Jenssen, Marte Andersen, Jeanette H. Hansen, Espen H. |
spellingShingle |
Hansen, Kine Ø. Hansen, Ida K. Ø. Richard, Céline S. Jenssen, Marte Andersen, Jeanette H. Hansen, Espen H. Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons |
author_facet |
Hansen, Kine Ø. Hansen, Ida K. Ø. Richard, Céline S. Jenssen, Marte Andersen, Jeanette H. Hansen, Espen H. |
author_sort |
Hansen, Kine Ø. |
title |
Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons |
title_short |
Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons |
title_full |
Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons |
title_fullStr |
Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons |
title_full_unstemmed |
Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons |
title_sort |
antimicrobial activity of securamines from the bryozoan securiflustra securifrons |
publisher |
SAGE Publications |
publishDate |
2021 |
url |
http://dx.doi.org/10.1177/1934578x21996180 http://journals.sagepub.com/doi/pdf/10.1177/1934578X21996180 http://journals.sagepub.com/doi/full-xml/10.1177/1934578X21996180 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Natural Product Communications volume 16, issue 2, page 1934578X2199618 ISSN 1934-578X 1555-9475 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1177/1934578x21996180 |
container_title |
Natural Product Communications |
container_volume |
16 |
container_issue |
2 |
container_start_page |
1934578X2199618 |
_version_ |
1809894236876701696 |