α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds
This study investigated in vitro the α-glucosidase inhibitory activity of resin from the Sakhalin fir tree ( Abies sachalinensis). The resin showed extremely high activity (IC 50 of 17.3 µg/mL). We isolated 8 compounds from the resin and identified them. All of the compounds isolated from A. sachali...
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crsagepubl:10.1177/1934578x19858460 2023-05-15T18:08:59+02:00 α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds Nakagawa, Toshinori Ashour, Ahmed Amen, Yhiya Koba, Yurie Ohnuki, Koichiro Shimizu, Kuniyoshi 2019 http://dx.doi.org/10.1177/1934578x19858460 http://journals.sagepub.com/doi/pdf/10.1177/1934578X19858460 http://journals.sagepub.com/doi/full-xml/10.1177/1934578X19858460 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Natural Product Communications volume 14, issue 6, page 1934578X1985846 ISSN 1934-578X 1555-9475 Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine journal-article 2019 crsagepubl https://doi.org/10.1177/1934578x19858460 2022-04-14T04:52:27Z This study investigated in vitro the α-glucosidase inhibitory activity of resin from the Sakhalin fir tree ( Abies sachalinensis). The resin showed extremely high activity (IC 50 of 17.3 µg/mL). We isolated 8 compounds from the resin and identified them. All of the compounds isolated from A. sachalinensis resin are reported for the first time in the present study. In an α-glucosidase inhibitory assay, 6 compounds—(holophyllane C (1), (−) -(24 E)-23-oxo-3,4- seco-9β H-lanosta-4(28),6,8(14),24-tetraen-3,26-dioic acid (2), abiesonic acid (3), (−) -(24 E)-23-oxo-3,4- seco-9β H-lanosta-4(28),7,24-triene-3,26-dioic acid (4), 3,4- seco-4(28),6,8(14),22Z,24-mariesapentaen-26,23-olide-3-oic acid (5), and (−) -abiesonic acid 3-methyl ester (6))—showed high activity (their IC 50 values were 25.1, 20.9, 82.4, 20.5, 27.3, and 20.5 µg/mL, respectively). These compounds should contribute to the resin’s α-glucosidase inhibitory activity. From an industrial point of view, these findings provide new data to support that the resin of A. sachalinensis is a rich source of α-glucosidase inhibitors, which are highly valuable for their potential to be developed as functional health foods. Article in Journal/Newspaper Sakhalin SAGE Publications (via Crossref) Natural Product Communications 14 6 1934578X1985846 |
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Open Polar |
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SAGE Publications (via Crossref) |
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language |
English |
topic |
Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine |
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Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine Nakagawa, Toshinori Ashour, Ahmed Amen, Yhiya Koba, Yurie Ohnuki, Koichiro Shimizu, Kuniyoshi α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds |
topic_facet |
Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine |
description |
This study investigated in vitro the α-glucosidase inhibitory activity of resin from the Sakhalin fir tree ( Abies sachalinensis). The resin showed extremely high activity (IC 50 of 17.3 µg/mL). We isolated 8 compounds from the resin and identified them. All of the compounds isolated from A. sachalinensis resin are reported for the first time in the present study. In an α-glucosidase inhibitory assay, 6 compounds—(holophyllane C (1), (−) -(24 E)-23-oxo-3,4- seco-9β H-lanosta-4(28),6,8(14),24-tetraen-3,26-dioic acid (2), abiesonic acid (3), (−) -(24 E)-23-oxo-3,4- seco-9β H-lanosta-4(28),7,24-triene-3,26-dioic acid (4), 3,4- seco-4(28),6,8(14),22Z,24-mariesapentaen-26,23-olide-3-oic acid (5), and (−) -abiesonic acid 3-methyl ester (6))—showed high activity (their IC 50 values were 25.1, 20.9, 82.4, 20.5, 27.3, and 20.5 µg/mL, respectively). These compounds should contribute to the resin’s α-glucosidase inhibitory activity. From an industrial point of view, these findings provide new data to support that the resin of A. sachalinensis is a rich source of α-glucosidase inhibitors, which are highly valuable for their potential to be developed as functional health foods. |
format |
Article in Journal/Newspaper |
author |
Nakagawa, Toshinori Ashour, Ahmed Amen, Yhiya Koba, Yurie Ohnuki, Koichiro Shimizu, Kuniyoshi |
author_facet |
Nakagawa, Toshinori Ashour, Ahmed Amen, Yhiya Koba, Yurie Ohnuki, Koichiro Shimizu, Kuniyoshi |
author_sort |
Nakagawa, Toshinori |
title |
α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds |
title_short |
α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds |
title_full |
α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds |
title_fullStr |
α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds |
title_full_unstemmed |
α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds |
title_sort |
α-glucosidase inhibitory activity of resin from sakhalin fir tree ( abies sachalinensis ) and its bioactive compounds |
publisher |
SAGE Publications |
publishDate |
2019 |
url |
http://dx.doi.org/10.1177/1934578x19858460 http://journals.sagepub.com/doi/pdf/10.1177/1934578X19858460 http://journals.sagepub.com/doi/full-xml/10.1177/1934578X19858460 |
genre |
Sakhalin |
genre_facet |
Sakhalin |
op_source |
Natural Product Communications volume 14, issue 6, page 1934578X1985846 ISSN 1934-578X 1555-9475 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/1934578x19858460 |
container_title |
Natural Product Communications |
container_volume |
14 |
container_issue |
6 |
container_start_page |
1934578X1985846 |
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1766181382611009536 |