In Vitro and In Vivo Antiangiogenic Activity of Crowberry ( Empetrum nigrum var. japonicum)
Crowberry, Empetrum nigrum var. japonicum, is widely used in folk medicine and grows naturally in Korea. Although some constituents and biological activity of Korean crowberry have been examined, there is little detailed information available. In this study, we investigated the effects of ethanol ex...
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crsagepubl:10.1177/1934578x1601100422 2024-09-15T18:03:20+00:00 In Vitro and In Vivo Antiangiogenic Activity of Crowberry ( Empetrum nigrum var. japonicum) Bae, Hong-Sook Kim, Hyun Ju Jeong, Da Hye Hosoya, Takahiro Kumazawa, Shigenori Jun, Mira Kim, Oh-Yoen Kim, Sun Wook Ahn, Mok-Ryeon 2016 http://dx.doi.org/10.1177/1934578x1601100422 http://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100422 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Natural Product Communications volume 11, issue 4, page 1934578X1601100 ISSN 1934-578X 1555-9475 journal-article 2016 crsagepubl https://doi.org/10.1177/1934578x1601100422 2024-07-29T04:24:41Z Crowberry, Empetrum nigrum var. japonicum, is widely used in folk medicine and grows naturally in Korea. Although some constituents and biological activity of Korean crowberry have been examined, there is little detailed information available. In this study, we investigated the effects of ethanol extracts of crowberry (EECB) on the inhibition of angiogenesis, both in vitro and in vivo. The effects of EECB were tested on in vitro models of angiogenesis, that is, tube formation and proliferation of human umbilical vein endothelial cells (HUVECs). EECB exhibited significant inhibitory effects on tube formation of HUVECs in a concentration-dependent manner. In addition, crowberry significantly suppressed the proliferation of HUVECs in a concentration-dependent manner. Furthermore, strong antiangiogenic activity of EECB samples was observed in the in vivo assay using chick embryo chorioallantoic membrane (CAM). These results indicate that crowberry may have potential applications in the prevention and treatment of angiogenesis-dependent human diseases. Article in Journal/Newspaper Crowberry Empetrum nigrum SAGE Publications Natural Product Communications 11 4 1934578X1601100 |
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English |
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Crowberry, Empetrum nigrum var. japonicum, is widely used in folk medicine and grows naturally in Korea. Although some constituents and biological activity of Korean crowberry have been examined, there is little detailed information available. In this study, we investigated the effects of ethanol extracts of crowberry (EECB) on the inhibition of angiogenesis, both in vitro and in vivo. The effects of EECB were tested on in vitro models of angiogenesis, that is, tube formation and proliferation of human umbilical vein endothelial cells (HUVECs). EECB exhibited significant inhibitory effects on tube formation of HUVECs in a concentration-dependent manner. In addition, crowberry significantly suppressed the proliferation of HUVECs in a concentration-dependent manner. Furthermore, strong antiangiogenic activity of EECB samples was observed in the in vivo assay using chick embryo chorioallantoic membrane (CAM). These results indicate that crowberry may have potential applications in the prevention and treatment of angiogenesis-dependent human diseases. |
format |
Article in Journal/Newspaper |
author |
Bae, Hong-Sook Kim, Hyun Ju Jeong, Da Hye Hosoya, Takahiro Kumazawa, Shigenori Jun, Mira Kim, Oh-Yoen Kim, Sun Wook Ahn, Mok-Ryeon |
spellingShingle |
Bae, Hong-Sook Kim, Hyun Ju Jeong, Da Hye Hosoya, Takahiro Kumazawa, Shigenori Jun, Mira Kim, Oh-Yoen Kim, Sun Wook Ahn, Mok-Ryeon In Vitro and In Vivo Antiangiogenic Activity of Crowberry ( Empetrum nigrum var. japonicum) |
author_facet |
Bae, Hong-Sook Kim, Hyun Ju Jeong, Da Hye Hosoya, Takahiro Kumazawa, Shigenori Jun, Mira Kim, Oh-Yoen Kim, Sun Wook Ahn, Mok-Ryeon |
author_sort |
Bae, Hong-Sook |
title |
In Vitro and In Vivo Antiangiogenic Activity of Crowberry ( Empetrum nigrum var. japonicum) |
title_short |
In Vitro and In Vivo Antiangiogenic Activity of Crowberry ( Empetrum nigrum var. japonicum) |
title_full |
In Vitro and In Vivo Antiangiogenic Activity of Crowberry ( Empetrum nigrum var. japonicum) |
title_fullStr |
In Vitro and In Vivo Antiangiogenic Activity of Crowberry ( Empetrum nigrum var. japonicum) |
title_full_unstemmed |
In Vitro and In Vivo Antiangiogenic Activity of Crowberry ( Empetrum nigrum var. japonicum) |
title_sort |
in vitro and in vivo antiangiogenic activity of crowberry ( empetrum nigrum var. japonicum) |
publisher |
SAGE Publications |
publishDate |
2016 |
url |
http://dx.doi.org/10.1177/1934578x1601100422 http://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100422 |
genre |
Crowberry Empetrum nigrum |
genre_facet |
Crowberry Empetrum nigrum |
op_source |
Natural Product Communications volume 11, issue 4, page 1934578X1601100 ISSN 1934-578X 1555-9475 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/1934578x1601100422 |
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Natural Product Communications |
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11 |
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4 |
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1934578X1601100 |
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1810440850769969152 |