CLUSTERS OF PARENTAL SOCIOECONOMIC STATUS IN EARLY CHILDHOOD AND INHERITED RISK FOR CEREBROVASCULAR DISEASE UNTIL MID-LIFE – NORTHERN FINLAND BIRTH COHORT 1966

• Published in: International Journal of Stroke
• Main Authors: Hyytiäinen, Veronika, Ala-Mursula, Leena, Oura, Petteri, Paananen, Markus, Karhunen, Ville, Rusanen, Harri, Geerlings, Mirjam I., Miettunen, Jouko, Rissanen, Ina
• Other Authors: Oulun Yliopistollinen Sairaala, National Institute for Health and Welfare, Helsinki, Finland, Ministry of Health and Social affairs, Finland, University of Oulu & The Research Council of Finland, Oulun Yliopisto, European Regional Development Fund ERDF, Jane ja Aatos Erkon Säätiö, Regional Institute of Occupational Health, Oulu, Finland, Signe ja Ane Gyllenbergin Säätiö, European Union's Horizon 2020 research and innovation programme
• Format: Article in Journal/Newspaper
• Language: English
• Published: SAGE Publications 2024
• Subjects: Northern Finland
• Online Access: http://dx.doi.org/10.1177/17474930241282521; https://journals.sagepub.com/doi/pdf/10.1177/17474930241282521

Background and Aims The incidence of cerebrovascular disease (CVD) is rising among young adults (<55 years). The risk for CVD starts to form in early childhood and is comprised of genetic and environmental risk factors. The aim of this study is to investigate the relationship between early family socioeconomic status (SES), inherited risk, and CVD until midlife. Methods In the Northern Finland Birth Cohort 1966 of 12,058 children, individuals were followed from gestational period up to 54 years. We used previously published early family SES clusters, based on latent class analysis of a wide set of prenatally collected variables. We investigated inherited risk with polygenic risk score (PRS) and parental CVDs during follow-up. The associations of the five distinct clusters, inherited risk, and consequent risk for various types of CVDs until middle age were analysed with Cox regression. All analyses were conducted first in the whole sample and then stratified by sex as is recommended in cardiovascular studies. Results During the follow-up of 586,943 person-years, 512 CVDs occurred. No clear association between SES clusters and CVD were found. Higher PRS associated with any CVD (HR per 1 SD increase 1.15; 95%CI 1.02-1.31), and ischemic CVD (HR 1.21; 1.05-1.40). We found no combined associations of early family SES and inherited risk for CVD. Conclusions Inherited risk was associated with the risk for CVD in mid-life in Finnish population. We found no clear connection with early family SES and CVD. Being born to a specific SES group did not increase the effect of inherited risk.