The impact of risk factor trends on intracerebral hemorrhage incidence over the last two decades—The Tromsø Study
Background Studies on the relationship between temporal trends in risk factors and incidence rates of intracerebral hemorrhage are scarce. Aims To analyze temporal trends in risk factors and incidence rates of intracerebral hemorrhage using individual data from a population-based study. Methods We i...
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crsagepubl:10.1177/1747493018789996 2024-09-15T18:39:24+00:00 The impact of risk factor trends on intracerebral hemorrhage incidence over the last two decades—The Tromsø Study Carlsson, Maria Wilsgaard, Tom Johnsen, Stein Harald Johnsen, Liv-Hege Løchen, Maja-Lisa Njølstad, Inger Bøgeberg Mathiesen, Ellisiv 2018 http://dx.doi.org/10.1177/1747493018789996 http://journals.sagepub.com/doi/pdf/10.1177/1747493018789996 http://journals.sagepub.com/doi/full-xml/10.1177/1747493018789996 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license International Journal of Stroke volume 14, issue 1, page 61-68 ISSN 1747-4930 1747-4949 journal-article 2018 crsagepubl https://doi.org/10.1177/1747493018789996 2024-07-01T04:23:59Z Background Studies on the relationship between temporal trends in risk factors and incidence rates of intracerebral hemorrhage are scarce. Aims To analyze temporal trends in risk factors and incidence rates of intracerebral hemorrhage using individual data from a population-based study. Methods We included 28,167 participants of the Tromsø Study enrolled between 1994 and 2008. First-ever intracerebral hemorrhages were registered through 31 December 2013. Hazard ratios (HRs) for intracerebral hemorrhage were analyzed by Cox proportional hazards models, risk factor levels over time by generalized estimating equations, and incidence rate ratios (IRR) by Poisson regression. Results We registered 219 intracerebral hemorrhages. Age, male sex, systolic blood pressure (BP), diastolic BP, and hypertension were associated with intracerebral hemorrhage. Hypertension was more strongly associated with non-lobar intracerebral hemorrhage (HR 5.08, 95% CI 2.86–9.01) than lobar intracerebral hemorrhage (HR 1.91, 95% CI 1.12–3.25). In women, incidence decreased significantly (IRR 0.46, 95% CI 0.23–0.90), driven by a decrease in non-lobar intracerebral hemorrhage. Incidence rates in men remained stable (IRR 1.27, 95% CI 0.69–2.31). BP levels were lower and decreased more steeply in women than in men. The majority with hypertension were untreated, and a high proportion of those treated did not reach treatment goals. Conclusions We observed a significant decrease in intracerebral hemorrhage incidence in women, but not in men. A steeper BP decrease in women may have contributed to the diverging trends. The high proportion of untreated and sub-optimally treated hypertension calls for improved strategies for prevention of intracerebral hemorrhage. Article in Journal/Newspaper Tromsø SAGE Publications International Journal of Stroke 14 1 61 68 |
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Background Studies on the relationship between temporal trends in risk factors and incidence rates of intracerebral hemorrhage are scarce. Aims To analyze temporal trends in risk factors and incidence rates of intracerebral hemorrhage using individual data from a population-based study. Methods We included 28,167 participants of the Tromsø Study enrolled between 1994 and 2008. First-ever intracerebral hemorrhages were registered through 31 December 2013. Hazard ratios (HRs) for intracerebral hemorrhage were analyzed by Cox proportional hazards models, risk factor levels over time by generalized estimating equations, and incidence rate ratios (IRR) by Poisson regression. Results We registered 219 intracerebral hemorrhages. Age, male sex, systolic blood pressure (BP), diastolic BP, and hypertension were associated with intracerebral hemorrhage. Hypertension was more strongly associated with non-lobar intracerebral hemorrhage (HR 5.08, 95% CI 2.86–9.01) than lobar intracerebral hemorrhage (HR 1.91, 95% CI 1.12–3.25). In women, incidence decreased significantly (IRR 0.46, 95% CI 0.23–0.90), driven by a decrease in non-lobar intracerebral hemorrhage. Incidence rates in men remained stable (IRR 1.27, 95% CI 0.69–2.31). BP levels were lower and decreased more steeply in women than in men. The majority with hypertension were untreated, and a high proportion of those treated did not reach treatment goals. Conclusions We observed a significant decrease in intracerebral hemorrhage incidence in women, but not in men. A steeper BP decrease in women may have contributed to the diverging trends. The high proportion of untreated and sub-optimally treated hypertension calls for improved strategies for prevention of intracerebral hemorrhage. |
format |
Article in Journal/Newspaper |
author |
Carlsson, Maria Wilsgaard, Tom Johnsen, Stein Harald Johnsen, Liv-Hege Løchen, Maja-Lisa Njølstad, Inger Bøgeberg Mathiesen, Ellisiv |
spellingShingle |
Carlsson, Maria Wilsgaard, Tom Johnsen, Stein Harald Johnsen, Liv-Hege Løchen, Maja-Lisa Njølstad, Inger Bøgeberg Mathiesen, Ellisiv The impact of risk factor trends on intracerebral hemorrhage incidence over the last two decades—The Tromsø Study |
author_facet |
Carlsson, Maria Wilsgaard, Tom Johnsen, Stein Harald Johnsen, Liv-Hege Løchen, Maja-Lisa Njølstad, Inger Bøgeberg Mathiesen, Ellisiv |
author_sort |
Carlsson, Maria |
title |
The impact of risk factor trends on intracerebral hemorrhage incidence over the last two decades—The Tromsø Study |
title_short |
The impact of risk factor trends on intracerebral hemorrhage incidence over the last two decades—The Tromsø Study |
title_full |
The impact of risk factor trends on intracerebral hemorrhage incidence over the last two decades—The Tromsø Study |
title_fullStr |
The impact of risk factor trends on intracerebral hemorrhage incidence over the last two decades—The Tromsø Study |
title_full_unstemmed |
The impact of risk factor trends on intracerebral hemorrhage incidence over the last two decades—The Tromsø Study |
title_sort |
impact of risk factor trends on intracerebral hemorrhage incidence over the last two decades—the tromsø study |
publisher |
SAGE Publications |
publishDate |
2018 |
url |
http://dx.doi.org/10.1177/1747493018789996 http://journals.sagepub.com/doi/pdf/10.1177/1747493018789996 http://journals.sagepub.com/doi/full-xml/10.1177/1747493018789996 |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
International Journal of Stroke volume 14, issue 1, page 61-68 ISSN 1747-4930 1747-4949 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/1747493018789996 |
container_title |
International Journal of Stroke |
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14 |
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1 |
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61 |
op_container_end_page |
68 |
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1810483776212434944 |