Rule of accumulation of enrofloxacin in Acipenser baerii and drug-induced damage to the tissues
Enrofloxacin (ENX) has been widely used in the prevention and control of bacterial diseases in sturgeon aquaculture due to its characteristics of wide antibacterial spectrum, strong antibacterial activity, less toxicity and fewer side effects, rapid action, extensive in vivo distribution, and little...
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crsagepubl:10.1177/1535370216654995 2023-05-15T13:01:48+02:00 Rule of accumulation of enrofloxacin in Acipenser baerii and drug-induced damage to the tissues Wang, Di Li, Shaowu Lu, Tongyan 2016 http://dx.doi.org/10.1177/1535370216654995 http://journals.sagepub.com/doi/pdf/10.1177/1535370216654995 http://journals.sagepub.com/doi/full-xml/10.1177/1535370216654995 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Experimental Biology and Medicine volume 241, issue 17, page 1977-1984 ISSN 1535-3702 1535-3699 General Biochemistry, Genetics and Molecular Biology journal-article 2016 crsagepubl https://doi.org/10.1177/1535370216654995 2022-09-28T19:08:45Z Enrofloxacin (ENX) has been widely used in the prevention and control of bacterial diseases in sturgeon aquaculture due to its characteristics of wide antibacterial spectrum, strong antibacterial activity, less toxicity and fewer side effects, rapid action, extensive in vivo distribution, and little cross-resistance with other antibiotics. However, the spinal abnormality was found in Acipenser baerii soon after ENX administration, which resulted an “S”-shaped curvature of the spine and retarded fish growth. It was still not clear whether ENX could cause spinal abnormality in sturgeons by now. The aim of this work was to determine the accumulation rule and toxicity of ENX to A. baerii when used at a high dose and/or unusually long durations. Here, ENX was orally given to A. baerii for 3–5 d continuously at the dosage of 0, 20, 40, and 80 mg/kg once daily, respectively. The accumulation of ENX in blood, liver, kidney, and cartilage was detected after withdrawal, and the tissues were made into sections for morphological examination. The results showed that the levels of ENX increased in the four tissues with the increase of dose and duration, and the ENX level in serum was far lower than that in other tissues. At 240 h, ENX levels in the four tissues decreased significantly. The histology indicated that the liver, kidney, and cartilage began to show structural damages at 5 d after withdrawal of 40 mg/kg ENX. The damage was aggravated at 3–5 d after withdrawal of 80 mg/kg ENX. At 240 h, the damaged tissues showed signs of recovery. These results suggested that ENX should be no more than 40 mg/kg and that exposure time should not be greater than 5 d to prevent liver, kidney, and cartilage damage. More attention should be paid to the impact of ENX on the occurrence and development of chondrocytes in juvenile A. baerii and the potential damage to the cartilage. Article in Journal/Newspaper Acipenser baerii SAGE Publications (via Crossref) Experimental Biology and Medicine 241 17 1977 1984 |
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SAGE Publications (via Crossref) |
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English |
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General Biochemistry, Genetics and Molecular Biology |
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General Biochemistry, Genetics and Molecular Biology Wang, Di Li, Shaowu Lu, Tongyan Rule of accumulation of enrofloxacin in Acipenser baerii and drug-induced damage to the tissues |
topic_facet |
General Biochemistry, Genetics and Molecular Biology |
description |
Enrofloxacin (ENX) has been widely used in the prevention and control of bacterial diseases in sturgeon aquaculture due to its characteristics of wide antibacterial spectrum, strong antibacterial activity, less toxicity and fewer side effects, rapid action, extensive in vivo distribution, and little cross-resistance with other antibiotics. However, the spinal abnormality was found in Acipenser baerii soon after ENX administration, which resulted an “S”-shaped curvature of the spine and retarded fish growth. It was still not clear whether ENX could cause spinal abnormality in sturgeons by now. The aim of this work was to determine the accumulation rule and toxicity of ENX to A. baerii when used at a high dose and/or unusually long durations. Here, ENX was orally given to A. baerii for 3–5 d continuously at the dosage of 0, 20, 40, and 80 mg/kg once daily, respectively. The accumulation of ENX in blood, liver, kidney, and cartilage was detected after withdrawal, and the tissues were made into sections for morphological examination. The results showed that the levels of ENX increased in the four tissues with the increase of dose and duration, and the ENX level in serum was far lower than that in other tissues. At 240 h, ENX levels in the four tissues decreased significantly. The histology indicated that the liver, kidney, and cartilage began to show structural damages at 5 d after withdrawal of 40 mg/kg ENX. The damage was aggravated at 3–5 d after withdrawal of 80 mg/kg ENX. At 240 h, the damaged tissues showed signs of recovery. These results suggested that ENX should be no more than 40 mg/kg and that exposure time should not be greater than 5 d to prevent liver, kidney, and cartilage damage. More attention should be paid to the impact of ENX on the occurrence and development of chondrocytes in juvenile A. baerii and the potential damage to the cartilage. |
format |
Article in Journal/Newspaper |
author |
Wang, Di Li, Shaowu Lu, Tongyan |
author_facet |
Wang, Di Li, Shaowu Lu, Tongyan |
author_sort |
Wang, Di |
title |
Rule of accumulation of enrofloxacin in Acipenser baerii and drug-induced damage to the tissues |
title_short |
Rule of accumulation of enrofloxacin in Acipenser baerii and drug-induced damage to the tissues |
title_full |
Rule of accumulation of enrofloxacin in Acipenser baerii and drug-induced damage to the tissues |
title_fullStr |
Rule of accumulation of enrofloxacin in Acipenser baerii and drug-induced damage to the tissues |
title_full_unstemmed |
Rule of accumulation of enrofloxacin in Acipenser baerii and drug-induced damage to the tissues |
title_sort |
rule of accumulation of enrofloxacin in acipenser baerii and drug-induced damage to the tissues |
publisher |
SAGE Publications |
publishDate |
2016 |
url |
http://dx.doi.org/10.1177/1535370216654995 http://journals.sagepub.com/doi/pdf/10.1177/1535370216654995 http://journals.sagepub.com/doi/full-xml/10.1177/1535370216654995 |
genre |
Acipenser baerii |
genre_facet |
Acipenser baerii |
op_source |
Experimental Biology and Medicine volume 241, issue 17, page 1977-1984 ISSN 1535-3702 1535-3699 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/1535370216654995 |
container_title |
Experimental Biology and Medicine |
container_volume |
241 |
container_issue |
17 |
container_start_page |
1977 |
op_container_end_page |
1984 |
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1766286982171852800 |